15 research outputs found
Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study
To examine demographic, environmental and clinical factors associated with severe bronchiolitis in infants admitted to hospital and quantify the independent effects of these factors
Role of deficits in pathogen recognition receptors in infection susceptibility
This work was supported by the
Northern Portugal Regional Operational Programme
(NORTE 2020), under the Portugal 2020 Partnership
Agreement, through the European Regional Development
Fund (FEDER) (NORTE-01-0145-FEDER-000013), and
the Fundação para a CiĂȘncia e Tecnologia (FCT)
(IF/00735/2014 to A.C. and SFRH/BPD/96176/2013 to
C.C.
The role of host genetic factors in respiratory tract infectious diseases:systematic review, meta-analyses and field synopsis
Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from IL4 gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29-2.14]). We also detected an association of TLR2 gene with tuberculosis (rs5743708; 3.19 [2.03-5.02]). Subset analyses identified CCL2 as an additional risk factor for tuberculosis (rs1024611; ORâ=â0.79 [0.72-0.88]). The IL4-TLR2-CCL2 axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidenc
The mechanism of deceleration of nucleation and crystal growth by the small addition of transition metals to lithium disilicate glasses
Bimodal run distribution in a northern population of sockeye salmon ( Oncorhynchus nerka
Crystal growth of la(2)srb(10)o(19)from undercooled melt
The crystal growth rate of La(2)SrB(10)O(19)in an undercooled melt of stoichiometric composition was studied. The crystallization of the bulk samples was performed in a single-stage regime under isothermal conditions at the selected temperatures for the different time periods. The surface crystallization was observed and in all crystallized samples, the La(2)SrB(10)O(19)crystalline phase was identified. Based on the dependence of the crystalline layer thickness on treatment time at selected temperature, crystal growth rate was obtained. The crystal growth rates were from 1.65 x 10(-8)to 2.77 x 10(-7)m s(-1)in the temperature interval (700-780 degrees C). The experimental values were compared to the calculated values using theoretical model of the crystal growth. The experimental growth rate followed the same trend as the calculated growth rate, but the experimental values were higher than the calculated