Receiver design for the uplink of base station cooperation systems employing SC-FDE modulations

The presented paper considers the uplink transmission in base station (BS) cooperation schemes where mobile terminals (MTs) in adjacent cells share the same physical channel. We consider single-carrier with frequency-domain equalization (SC-FDE) combined with iterative frequency-domain receivers based on the iterative block decision feedback equalization (IB-DFE). We study the quantization requirements when sending the received signals, from different MTs, at different BSs to a central unit that performs the separation of different MTs using iterative frequency-domain receivers. Our performance results show that a relatively coarse quantization, with only 4 bits in the in-phase and quadrature components of the complex envelope already allows close-to-optimum macro-diversity gains, as well as an efficient separation of the transmitted signals associated with each MT

Early postural blood pressure response and cause-specific mortality among middle-aged adults

Orthostatic hypotension (OH) is associated with increased total mortality but contribution of specific death causes has not been thoroughly explored. In this prospective study, authors followed up 32,068 individuals without baseline history of cancer or cardiovascular disease (69% men; mean age, 46 years; range, 26–61 years) over a period of 24 years. Hazard ratios (HRs) for total and cause-specific mortality associated with presence of OH and by quartiles of postural systolic blood pressure response (∆SBP) were assessed using multivariate adjusted Cox regression model. A total of 7,145 deaths (22.3%, 9.4 deaths/1,000 person-years) occurred during follow-up. Those with OH (n = 1,943) had higher risk of death due to injury (HR, 1.88; 1.37–2.57) and neurological disease (HR, 2.21; 1.39–3.51). Analogically, risk of death caused by injury and neurological disease increased across the quartiles of ∆SBP from hyper- (Q1SBP, +8.5 ± 4.7 mmHg) to hypotensive response (Q4SBP, −13.7 ± 5.7 mmHg; HR, 1.32; 1.00–1.72, and 1.84; 1.20–2.82, respectively) as did also risk of death due to respiratory disease (Q4SBP vs. Q1SBP: HR, 1.53; 1.14–2.04). In contrast, risk curve for cerebrovascular death was U-shaped with nadir in the mildly hypotensive 3rd quartile of ∆SBP (−5.0 ± 0.1 mmHg, Q3SBP vs. Q1SBP: HR, 0.75; 0.54–1.03; P for linear trend = 0.021). Additionally, cardiovascular mortality was increased among 5,805 rescreened participants (mean age, 53 years; 9.8% OH positive: HR, 1.54; 1.24–1.89, and Q4SBP vs. Q1SBP: 1.27; 1.02–1.57, respectively). In summary, increased mortality predicted by blood pressure fall on standing is associated with injuries, neurodegenerative, and respiratory diseases, as well as with cardiovascular disease in older adults. Moreover, both increase and pronounced decrease of SBP during early orthostasis indicate higher risk of cerebrovascular death

A surge of light at the birth of a supernova.

It is difficult to establish the properties of massive stars that explode as supernovae. The electromagnetic emission during the first minutes to hours after the emergence of the shock from the stellar surface conveys important information about the final evolution and structure of the exploding star. However, the unpredictable nature of supernova events hinders the detection of this brief initial phase. Here we report the serendipitous discovery of a newly born, normal type IIb supernova (SN 2016gkg), which reveals a rapid brightening at optical wavelengths of about 40 magnitudes per day. The very frequent sampling of the observations allowed us to study in detail the outermost structure of the progenitor of the supernova and the physics of the emergence of the shock. We develop hydrodynamical models of the explosion that naturally account for the complete evolution of the supernova over distinct phases regulated by different physical processes. This result suggests that it is appropriate to decouple the treatment of the shock propagation from the unknown mechanism that triggers the explosion

Varying constants, Gravitation and Cosmology

Fundamental constants are a cornerstone of our physical laws. Any constant varying in space and/or time would reflect the existence of an almost massless field that couples to matter. This will induce a violation of the universality of free fall. It is thus of utmost importance for our understanding of gravity and of the domain of validity of general relativity to test for their constancy. We thus detail the relations between the constants, the tests of the local position invariance and of the universality of free fall. We then review the main experimental and observational constraints that have been obtained from atomic clocks, the Oklo phenomenon, Solar system observations, meteorites dating, quasar absorption spectra, stellar physics, pulsar timing, the cosmic microwave background and big bang nucleosynthesis. At each step we describe the basics of each system, its dependence with respect to the constants, the known systematic effects and the most recent constraints that have been obtained. We then describe the main theoretical frameworks in which the low-energy constants may actually be varying and we focus on the unification mechanisms and the relations between the variation of different constants. To finish, we discuss the more speculative possibility of understanding their numerical values and the apparent fine-tuning that they confront us with.Comment: 145 pages, 10 figures, Review for Living Reviews in Relativit

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

A comprehensive literature search was performed to collate evidence of mitochondrial dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, features of mitochondrial dysfunction in the general population of children with ASD were identified. Second, characteristics of mitochondrial dysfunction in children with ASD and concomitant mitochondrial disease (MD) were compared with published literature of two general populations: ASD children without MD, and non-ASD children with MD. The prevalence of MD in the general population of ASD was 5.0% (95% confidence interval 3.2, 6.9%), much higher than found in the general population (∼0.01%). The prevalence of abnormal biomarker values of mitochondrial dysfunction was high in ASD, much higher than the prevalence of MD. Variances and mean values of many mitochondrial biomarkers (lactate, pyruvate, carnitine and ubiquinone) were significantly different between ASD and controls. Some markers correlated with ASD severity. Neuroimaging, in vitro and post-mortem brain studies were consistent with an elevated prevalence of mitochondrial dysfunction in ASD. Taken together, these findings suggest children with ASD have a spectrum of mitochondrial dysfunction of differing severity. Eighteen publications representing a total of 112 children with ASD and MD (ASD/MD) were identified. The prevalence of developmental regression (52%), seizures (41%), motor delay (51%), gastrointestinal abnormalities (74%), female gender (39%), and elevated lactate (78%) and pyruvate (45%) was significantly higher in ASD/MD compared with the general ASD population. The prevalence of many of these abnormalities was similar to the general population of children with MD, suggesting that ASD/MD represents a distinct subgroup of children with MD. Most ASD/MD cases (79%) were not associated with genetic abnormalities, raising the possibility of secondary mitochondrial dysfunction. Treatment studies for ASD/MD were limited, although improvements were noted in some studies with carnitine, co-enzyme Q10 and B-vitamins. Many studies suffered from limitations, including small sample sizes, referral or publication biases, and variability in protocols for selecting children for MD workup, collecting mitochondrial biomarkers and defining MD. Overall, this evidence supports the notion that mitochondrial dysfunction is associated with ASD. Additional studies are needed to further define the role of mitochondrial dysfunction in ASD

Approaches to the Management of Sensitized Lung Transplant Candidates: Findings from an International Survey

PURPOSE: Highly sensitized lung transplant candidates undergo transplant at a significantly lower rate than unsensitized candidates. We conducted a survey to understand the approach to waitlist and peri-operative management of these candidates across programs worldwide. METHODS: Lung transplant programs were invited to complete the survey either online or by telephone. Survey questions pertained to programs' method of human leukocyte antigen (HLA) antibody detection, characterization of HLA antibody risk, incorporation of virtual (VCM) and actual crossmatch (ACM) results in organ allocation decisions, and use of pre or peri-operative desensitization therapy between January 2018 and October 2019. RESULTS: 57 adult (39/57), pediatric (4/57), and combined (14/57) lung transplant programs were surveyed. Respondents were transplant physicians (46/57), surgeons (3/57), or several multi-disciplinary team members (8/57) from programs in North America (39/57), Europe (11/57), Asia (3/57), Australia (3/57), and Africa (1/57). Regarding organ allocation, 32/57 programs decline offers for candidates who are highly sensitized/critically ill on the basis of an unacceptable VCM. A high degree of sensitization is a contraindication to transplant at 12/57 programs, and a contraindication to using mechanical support as bridge-to-transplant at 19/57. At 19/57 programs, offers are accepted regardless of positive VCM results if the prospective flow crossmatch (4/19) or complement-dependent cytotoxicity crossmatch (15/19) is negative, either for all candidates (9/19) or only for those who are highly sensitized/critically ill (10/19). A minority of programs (8/57) accept offers regardless of positive VCM or ACM results, either for all candidates (1/8) or only for those who are highly sensitized/critically ill (7/8). All of these programs use plasmapheresis, intravenous immune globulin, thymoglobulin, and/or rituximab peri-operatively. Currently, 13/57 programs treat highly sensitized candidates on the waitlist with various desensitization therapies to improve their likelihood of receiving an acceptable offer. CONCLUSION: There is significant variation in the management of sensitized lung transplant candidates across programs. Further research and international consensus are needed to improve access to transplant for these patients