Cosmological constant constraints from observation-derived energy condition bounds and their application to bimetric massive gravity

Among the various possibilities to probe the theory behind the recent accelerated expansion of the universe, the energy conditions (ECs) are of particular interest, since it is possible to confront and constrain the many models, including different theories of gravity, with observational data. In this context, we use the ECs to probe any alternative theory whose extra term acts as a cosmological constant. For this purpose, we apply a model-independent approach to reconstruct the recent expansion of the universe. Using Type Ia supernova, baryon acoustic oscillations and cosmic-chronometer data, we perform a Markov Chain Monte Carlo analysis to put constraints on the effective cosmological constant $\Omega^0_{\rm eff}$. By imposing that the cosmological constant is the only component that possibly violates the ECs, we derive lower and upper bounds for its value. For instance, we obtain that $0.59 < \Omega^0_{\rm eff} < 0.91$ and $0.40 < \Omega^0_{\rm eff} < 0.93$ within, respectively, $1\sigma$ and $3\sigma$ confidence levels. In addition, about 30\% of the posterior distribution is incompatible with a cosmological constant, showing that this method can potentially rule it out as a mechanism for the accelerated expansion. We also study the consequence of these constraints for two particular formulations of the bimetric massive gravity. Namely, we consider the Visser's theory and the Hassan and Roses's massive gravity by choosing a background metric such that both theories mimic General Relativity with a cosmological constant. Using the $\Omega^0_{\rm eff}$ observational bounds along with the upper bounds on the graviton mass we obtain constraints on the parameter spaces of both theories.Comment: 11 pages, 4 figures, 1 tabl

Postmenopausal Osteoporosis reference genes for qPCR expression assays

Osteoporosis (OP) is a multifactorial disease influenced by genetic factors in more than half of the cases. In spite of the efforts to clarify the relationship among genetic factors and susceptibility to develop OP, many genetic associations need to be further functionally validated. Besides, some limitations as the choice of stably expressed reference genes (RG) should be overcome to ensure the quality and reproducibility of gene expression assays. To our knowledge, a validation study for RG in OP is still missing. We compared the expression levels, using polymerase chain reaction quantitative real time (qPCR) of 10 RG (G6PD, B2M, GUSB, HSP90, EF1A, RPLP0, GAPDH, ACTB, 18 S and HPRT1) to assess their suitability in OP analysis by using GeNorm, Normfinder, BestKeeper and RefFinder programs. A minimal number of two RG was recommended by GeNorm to obtain a reliable normalization. RPLP0 and B2M were identified as the most stable genes in OP studies while ACTB, 18 S and HPRT1 were inadequate for normalization in our data set. Moreover, we showed the dramatic effects of suboptimal RG choice on the quantification of a target gene, highlighting the importance in the identification of the most appropriate reference gene to specific diseases. We suggest the use of RPLP0 and B2M as the most stable reference genes while we do not recommend the use of the least stable reference genes HPRT1, 18 S and ACTB in OP expression assays using PBMC as biological source. Additionally, we emphasize the importance of individualized and careful choice in software and reference genes selection

Monitoramento da qualidade física de um argissolo sob plantio direto de milho e de mamona.

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Qualidade e compostos bioativos na uva Syrah influenciados pelas práticas culturais de desfolha e desponte: avaliação preliminar.

Em parreiral irrigado da cultivar Syrah, enxertada sobre IAC 766, avaliou-se a qualidade e o teor de compostos bioativos nas bagas sob influência das práticas de desfolha e desponte em diferentes fases fenológicas