10 research outputs found

    3D quantification of mandibular asymmetry using the SPHARM-PDM tool box

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    Pretreatment diagnosis of mandibular asymmetry in orthognathic surgery patients can be improved by quantitative shape modeling and analysis. The UNC SPHARM-PDM (University of North Carolina Spherical Harmonics—Point Distribution Model) toolbox was applied to a cohort of patients and the results were evaluated

    A validation of carbon fiber imaging couch top modeling in two radiation therapy treatment planning systems: Philips Pinnacle<sup>3</sup> and BrainLAB iPlan RT Dose

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    <p>Abstract</p> <p>Background</p> <p>Carbon fiber (CF) is now the material of choice for radiation therapy couch tops. Initial designs included side metal bars for rigidity; however, with the advent of IGRT, involving on board imaging, new thicker CF couch tops without metal bars have been developed. The new design allows for excellent imaging at the expense of potentially unacceptable dose attenuation and perturbation.</p> <p>Objectives</p> <p>We set out to model the BrainLAB imaging couch top (ICT) in Philips Pinnacle<sup>3</sup> treatment planning system (TPS), to validate the already modeled ICT in BrainLAB iPlan RT Dose treatment planning system and to compute the magnitude of the loss in skin sparing.</p> <p>Results</p> <p>Using CF density of 0.55 g/cm<sup>3</sup> and foam density of 0.03 g/cm<sup>3</sup>, we demonstrated an excellent agreement between measured dose and Pinnacle<sup>3</sup> TPS computed dose using 6 MV beam. The agreement was within 1% for all gantry angle measured except for 120<sup>o</sup>, which was 1.8%. The measured and iPlan RT Dose TPS computed dose agreed to within 1% for all gantry angles and field sizes measured except for 100<sup>o</sup> where the agreement was 1.4% for 10 cm × 10 cm field size. Predicted attenuation through the couch by iPlan RT Dose TPS (3.4% - 9.5%) and Pinnacle<sup>3</sup> TPS (2% - 6.6%) were within the same magnitude and similar to previously reported in the literature. Pinnacle<sup>3</sup> TPS estimated an 8% to 20% increase in skin dose with increase in field size. With the introduction of the CF couch top, it estimated an increase in skin dose by approximately 46 - 90%. The clinical impact of omitting the couch in treatment planning will be dependent on the beam arrangement, the percentage of the beams intersecting the couch and their angles of incidence.</p> <p>Conclusion</p> <p>We have successfully modeled the ICT in Pinnacle<sup>3</sup> TPS and validated the modeled ICT in iPlan RT Dose. It is recommended that the ICT be included in treatment planning for all treatments that involve posteriors beams. There is a significant increase in skin dose that is dependent on the percentage of the beam passing through the couch and the angle of incidence.</p

    Chemical Modification and Cleavage of Proteins and Chemical Strategy in Immunochemical Studies of Proteins

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