Ceruloplasmin Deficiency Reduces Levels of Iron and BDNF in the Cortex and Striatum of Young Mice and Increases Their Vulnerability to Stroke

Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficking. Previous findings suggest that the proper regulation and subcellular localization of iron are very important in brain cell function and viability. Brain iron dyshomeostasis is observed during normal aging, as well as in several neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases, coincident with areas more susceptible to insults. Because of their high metabolic demand and electrical excitability, neurons are particularly vulnerable to ischemic injury and death. We therefore set out to look for abnormalities in the brain of young adult mice that lack Cp. We found that iron levels in the striatum and cerebral cortex of these young animals are significantly lower than wild-type (WT) controls. Also mRNA levels of the neurotrophin brain derived neurotrophic factor (BDNF), known for its role in maintenance of cell viability, were decreased in these brain areas. Chelator-mediated depletion of iron in cultured neural cells resulted in reduced BDNF expression by a posttranscriptional mechanism, suggesting a causal link between low brain iron levels and reduced BDNF expression. When the mice were subjected to middle cerebral artery occlusion, a model of focal ischemic stroke, we found increased brain damage in Cp-deficient mice compared to WT controls. Our data indicate that lack of Cp increases neuronal susceptibility to ischemic injury by a mechanism that may involve reduced levels of iron and BDNF

J/psi production cross section and its dependence on charged-particle multiplicity in p plus p collisions at root s=200 GeV

We present a measurement of inclusive J/ψ production at mid-rapidity (|y|<1) in p+p collisions at a center-of-mass energy of s=200 GeV with the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The differential production cross section for J/ψ as a function of transverse momentum (pT) for 0<pT<14 GeV/c and the total cross section are reported and compared to calculations from the color evaporation model and the non-relativistic Quantum Chromodynamics model. The dependence of J/ψ relative yields in three pT intervals on charged-particle multiplicity at mid-rapidity is measured for the first time in p+p collisions at s=200 GeV and compared with that measured at s=7 TeV, PYTHIA8 and EPOS3 Monte Carlo generators, and the Percolation model prediction. Keywords: Quarkonium, p+p collisions, Multiple parton interactions, Charged-particle multiplicit

Measurement of the longitudinal spin asymmetries for weak boson production in proton-proton collisions at root s=510 GeV

354We report new STAR measurements of the single-spin asymmetries AL for W+ and W- bosons produced in polarized proton-proton collisions at s=510  GeV as a function of the decay-positron and decay-electron pseudorapidity. The data were obtained in 2013 and correspond to an integrated luminosity of 250  pb-1. The results are combined with previous results obtained with 86  pb-1. A comparison with theoretical expectations based on polarized lepton-nucleon deep-inelastic scattering and prior polarized proton-proton data suggests a difference between the u¯ and d¯ quark helicity distributions for 0.05<x<0.25. In addition, we report new results for the double-spin asymmetries ALL for W±, as well as AL for Z/γ* production and subsequent decay into electron-positron pairs.openopenAdam, J.; Adamczyk, L.; Adams, J. R.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Anderson, D. M.; Aoyama, R.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Ashraf, M. U.; Atetalla, F.; Attri, A.; Averichev, G. S.; Bairathi, V.; Barish, K.; Bassill, A. J.; Behera, A.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Brandenburg, J. D.; Brandin, A. V.; Brown, D.; Bryslawskyj, J.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Cebra, D.; Chakaberia, I.; Chaloupka, P.; Chan, B. K.; Chang, F-H.; Chang, Z.; Chankova-Bunzarova, N.; Chatterjee, A.; Chattopadhyay, S.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Csanad, M.; Das, S.; Dedovich, T. G.; Deppner, I. M.; Derevschikov, A. A.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Dunlop, J. C.; Edmonds, T.; Efimov, L. G.; Elsey, N.; Engelage, J.; Eppley, G.; Esha, R.; Esumi, S.; Evdokimov, O.; Ewigleben, J.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Fedorisin, J.; Feng, Y.; Filip, P.; Finch, E.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Galatyuk, T.; Geurts, F.; Gibson, A.; Grosnick, D.; Gunarathne, D. S.; Gupta, A.; Guryn, W.; Hamad, A. I.; Hamed, A.; Harlenderova, A.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Herrmann, N.; Holub, L.; Hong, Y.; Horvat, S.; Huang, B.; Huang, H. Z.; Huang, S. L.; Huang, T.; Huang, X.; Humanic, T. J.; Huo, P.; Igo, G.; Jacobs, W. W.; Jentsch, A.; Jia, J.; Jiang, K.; Jowzaee, S.; Ju, X.; Judd, E. G.; Kabana, S.; Kagamaster, S.; Kalinkin, D.; Kang, K.; Kapukchyan, D.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Kelsey, M.; Kikoła, D. P.; Kim, C.; Kinghorn, T. A.; Kisel, I.; Kisiel, A.; Kocan, M.; Kochenda, L.; Kosarzewski, L. K.; Kraishan, A. F.; Kramarik, L.; Kravtsov, P.; Krueger, K.; Kulathunga Mudiyanselage, N.; Kumar, L.; Kunnawalkam Elayavalli, R.; Kvapil, J.; Kwasizur, J. H.; Lacey, R.; Landgraf, J. M.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, C.; Li, W.; Li, W.; Li, X.; Li, Y.; Liang, Y.; Licenik, R.; Lidrych, J.; Lin, T.; Lipiec, A.; Lisa, M. A.; Liu, F.; Liu, H.; Liu, P.; Liu, P.; Liu, X.; Liu, Y.; Liu, Z.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, S.; Luo, X.; Ma, G. L.; Ma, L.; Ma, R.; Ma, Y. G.; Magdy, N.; Majka, R.; Mallick, D.; Margetis, S.; Markert, C.; Matis, H. S.; Matonoha, O.; Mazer, J. A.; Meehan, K.; Mei, J. C.; Minaev, N. G.; Mioduszewski, S.; Mishra, D.; Mohanty, B.; Mondal, M. M.; Mooney, I.; Moravcova, Z.; Morozov, D. A.; Nasim, Md.; Nayak, K.; Nelson, J. M.; Nemes, D. B.; Nie, M.; Nigmatkulov, G.; Niida, T.; Nogach, L. V.; Nonaka, T.; Odyniec, G.; Ogawa, A.; Oh, K.; Oh, S.; Okorokov, V. A.; Olvitt, D.; Page, B. S.; Pak, R.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Pinter, R. L.; Pluta, J.; Porter, J.; Posik, M.; Pruthi, N. K.; Przybycien, M.; Putschke, J.; Quintero, A.; Radhakrishnan, S. K.; Ramachandran, S.; Ray, R. L.; Reed, R.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Salur, S.; Sandweiss, J.; Schambach, J.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Schweid, B. R.; Seck, F.; Seger, J.; Sergeeva, M.; Seto, R.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Shen, W. Q.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Siejka, S.; Sikora, R.; Simko, M.; Singh, J.; Singha, S.; Smirnov, D.; Smirnov, N.; Solyst, W.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Stewart, D. J.; Strikhanov, M.; Stringfellow, B.; Suaide, A. A. P.; Sugiura, T.; Sumbera, M.; Summa, B.; Sun, X. M.; Sun, Y.; Sun, Y.; Surrow, B.; Svirida, D. N.; Szymanski, P.; Tang, A. H.; Tang, Z.; Taranenko, A.; Tarnowsky, T.; Thomas, J. H.; Timmins, A. R.; Todoroki, T.; Tokarev, M.; Tomkiel, C. A.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Tsai, O. D.; Tu, B.; Ullrich, T.; Underwood, D. G.; Upsal, I.; Van Buren, G.; Vanek, J.; Vasiliev, A. N.; Vassiliev, I.; Videbæk, F.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, F.; Wang, G.; Wang, P.; Wang, Y.; Wang, Y.; Webb, J. C.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y.; Xiao, Z. G.; Xie, G.; Xie, W.; Xu, H.; Xu, N.; Xu, Q. H.; Xu, Y. F.; Xu, Z.; Yang, C.; Yang, Q.; Yang, S.; Yang, Y.; Ye, Z.; Ye, Z.; Yi, L.; Yip, K.; Yoo, I. -K.; Zbroszczyk, H.; Zha, W.; Zhang, D.; Zhang, J.; Zhang, L.; Zhang, S.; Zhang, S.; Zhang, X. P.; Zhang, Y.; Zhang, Z.; Zhao, J.; Zhong, C.; Zhou, C.; Zhu, X.; Zhu, Z.; Zurek, M.; Zyzak, M.Adam, J.; Adamczyk, L.; Adams, J.  R.; Adkins, J.  K.; Agakishiev, G.; Aggarwal, M.  M.; Ahammed, Z.; Alekseev, I.; Anderson, D.  M.; Aoyama, R.; Aparin, A.; Arkhipkin, D.; Aschenauer, E.  C.; Ashraf, M.  U.; Atetalla, F.; Attri, A.; Averichev, G.  S.; Bairathi, V.; Barish, K.; Bassill, A.  J.; Behera, A.; Bellwied, R.; Bhasin, A.; Bhati, A.  K.; Bielcik, J.; Bielcikova, J.; Bland, L.  C.; Bordyuzhin, I.  G.; Brandenburg, J.  D.; Brandin, A.  V.; Brown, D.; Bryslawskyj, J.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Cebra, D.; Chakaberia, I.; Chaloupka, P.; Chan, B.  K.; Chang, F-H.; Chang, Z.; Chankova-Bunzarova, N.; Chatterjee, A.; Chattopadhyay, S.; Chen, J.  H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H.  J.; Csanad, M.; Das, S.; Dedovich, T.  G.; Deppner, I.  M.; Derevschikov, A.  A.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J.  L.; Dunlop, J.  C.; Edmonds, T.; Efimov, L.  G.; Elsey, N.; Engelage, J.; Eppley, G.; Esha, R.; Esumi, S.; Evdokimov, O.; Ewigleben, J.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Fedorisin, J.; Feng, Y.; Filip, P.; Finch, E.; Fisyak, Y.; Flores, C.  E.; Fulek, L.; Gagliardi, C.  A.; Galatyuk, T.; Geurts, F.; Gibson, A.; Grosnick, D.; Gunarathne, D.  S.; Gupta, A.; Guryn, W.; Hamad, A.  I.; Hamed, A.; Harlenderova, A.; Harris, J.  W.; He, L.; Heppelmann, S.; Heppelmann, S.; Herrmann, N.; Holub, L.; Hong, Y.; Horvat, S.; Huang, B.; Huang, H.  Z.; Huang, S.  L.; Huang, T.; Huang, X.; Humanic, T.  J.; Huo, P.; Igo, G.; Jacobs, W.  W.; Jentsch, A.; Jia, J.; Jiang, K.; Jowzaee, S.; Ju, X.; Judd, E.  G.; Kabana, S.; Kagamaster, S.; Kalinkin, D.; Kang, K.; Kapukchyan, D.; Kauder, K.; Ke, H.  W.; Keane, D.; Kechechyan, A.; Kelsey, M.; Kikoła, D.  P.; Kim, C.; Kinghorn, T.  A.; Kisel, I.; Kisiel, A.; Kocan, M.; Kochenda, L.; Kosarzewski, L.  K.; Kraishan, A.  F.; Kramarik, L.; Kravtsov, P.; Krueger, K.; Kulathunga Mudiyanselage, N.; Kumar, L.; Kunnawalkam Elayavalli, R.; Kvapil, J.; Kwasizur, J.  H.; Lacey, R.; Landgraf, J.  M.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J.  H.; Li, C.; Li, W.; Li, W.; Li, X.; Li, Y.; Liang, Y.; Licenik, R.; Lidrych, J.; Lin, T.; Lipiec, A.; Lisa, M.  A.; Liu, F.; Liu, H.; Liu, P.; Liu, P.; Liu, X.; Liu, Y.; Liu, Z.; Ljubicic, T.; Llope, W.  J.; Lomnitz, M.; Longacre, R.  S.; Luo, S.; Luo, X.; Ma, G.  L.; Ma, L.; Ma, R.; Ma, Y.  G.; Magdy, N.; Majka, R.; Mallick, D.; Margetis, S.; Markert, C.; Matis, H.  S.; Matonoha, O.; Mazer, J.  A.; Meehan, K.; Mei, J.  C.; Minaev, N.  G.; Mioduszewski, S.; Mishra, D.; Mohanty, B.; Mondal, M.  M.; Mooney, I.; Moravcova, Z.; Morozov, D.  A.; Nasim, Md.; Nayak, K.; Nelson, J.  M.; Nemes, D.  B.; Nie, M.; Nigmatkulov, G.; Niida, T.; Nogach, L.  V.; Nonaka, T.; Odyniec, G.; Ogawa, A.; Oh, K.; Oh, S.; Okorokov, V.  A.; Olvitt, D.; Page, B.  S.; Pak, R.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Pinter, R.  L.; Pluta, J.; Porter, J.; Posik, M.; Pruthi, N.  K.; Przybycien, M.; Putschke, J.; Quintero, A.; Radhakrishnan, S.  K.; Ramachandran, S.; Ray, R.  L.; Reed, R.; Ritter, H.  G.; Roberts, J.  B.; Rogachevskiy, O.  V.; Romero, J.  L.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N.  R.; Sahu, P.  K.; Salur, S.; Sandweiss, J.; Schambach, J.; Schmah, A.  M.; Schmidke, W.  B.; Schmitz, N.; Schweid, B.  R.; Seck, F.; Seger, J.; Sergeeva, M.; Seto, R.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P.  V.; Shao, M.; Shen, W.  Q.; Shi, S.  S.; Shou, Q.  Y.; Sichtermann, E.  P.; Siejka, S.; Sikora, R.; Simko, M.; Singh, J.; Singha, S.; Smirnov, D.; Smirnov, N.; Solyst, W.; Sorensen, P.; Spinka, H.  M.; Srivastava, B.; Stanislaus, T.  D.  S.; Stewart, D.  J.; Strikhanov, M.; Stringfellow, B.; Suaide, A.  A.  P.; Sugiura, T.; Sumbera, M.; Summa, B.; Sun, X.  M.; Sun, Y.; Sun, Y.; Surrow, B.; Svirida, D.  N.; Szymanski, P.; Tang, A.  H.; Tang, Z.; Taranenko, A.; Tarnowsky, T.; Thomas, J.  H.; Timmins, A.  R.; Todoroki, T.; Tokarev, M.; Tomkiel, C.  A.; Trentalange, S.; Tribble, R.  E.; Tribedy, P.; Tripathy, S.  K.; Tsai, O.  D.; Tu, B.; Ullrich, T.; Underwood, D.  G.; Upsal, I.; Van Buren, G.; Vanek, J.; Vasiliev, A.  N.; Vassiliev, I.; Videbæk, F.; Vokal, S.; Voloshin, S.  A.; Vossen, A.; Wang, F.; Wang, G.; Wang, P.; Wang, Y.; Wang, Y.; Webb, J.  C.; Wen, L.; Westfall, G.  D.; Wieman, H.; Wissink, S.  W.; Witt, R.; Wu, Y.; Xiao, Z.  G.; Xie, G.; Xie, W.; Xu, H.; Xu, N.; Xu, Q.  H.; Xu, Y.  F.; Xu, Z.; Yang, C.; Yang, Q.; Yang, S.; Yang, Y.; Ye, Z.; Ye, Z.; Yi, L.; Yip, K.; Yoo, I. -K.; Zbroszczyk, H.; Zha, W.; Zhang, D.; Zhang, J.; Zhang, L.; Zhang, S.; Zhang, S.; Zhang, X.  P.; Zhang, Y.; Zhang, Z.; Zhao, J.; Zhong, C.; Zhou, C.; Zhu, X.; Zhu, Z.; Zurek, M.; Zyzak, M