Charge Dynamics in Cuprate Superconductors

In this lecture we present some interesting issues that arise when the dynamics of the charge carriers in the CuO$_2$ planes of the high temperature superconductors is considered. Based on the qualitative picture of doping, set by experiments and some previous calculations, we consider the strength of various inter and intra-cell charge transfer susceptibilities, the question of Coulomb screening and charge collective modes. The starting point is the usual p-d model extended by the long range Coulomb (LRC) interaction. Within this model it is possible to examine the case in which the LRC forces frustrate the electronic phase separation, the instability which is present in the model without an LRC interaction. While the static dielectric function in such systems is negative down to arbitrarily small wavevectors, the system is not unstable. We consider the dominant electronic charge susceptibilities and possible consequences for the lattice properties.Comment: 14 pages, 15 figures, latex, to be published in "From Quantum Mechanics to Technology", Lecture Notes in Physics, Springe

Ring exchange, the Bose metal, and bosonization in two dimensions

Motivated by the high-T_c cuprates, we consider a model of bosonic Cooper pairs moving on a square lattice via ring exchange. We show that this model offers a natural middle ground between a conventional antiferromagnetic Mott insulator and the fully deconfined fractionalized phase which underlies the spin-charge separation scenario for high-T_c superconductivity. We show that such ring models sustain a stable critical phase in two dimensions, the *Bose metal*. The Bose metal is a compressible state, with gapless but uncondensed boson and ``vortex'' excitations, power-law superconducting and charge-ordering correlations, and broad spectral functions. We characterize the Bose metal with the aid of an exact plaquette duality transformation, which motivates a universal low energy description of the Bose metal. This description is in terms of a pair of dual bosonic phase fields, and is a direct analog of the well-known one-dimensional bosonization approach. We verify the validity of the low energy description by numerical simulations of the ring model in its exact dual form. The relevance to the high-T_c superconductors and a variety of extensions to other systems are discussed, including the bosonization of a two dimensional fermionic ring model

Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrPC binding and downstream pathways

Amyloid β oligomers (Aβo) are the main toxic species in Alzheimer's disease, which have been targeted for single drug treatment with very little success. In this work we report a new approach for identifying functional Aβo binding compounds. A tailored library of 971 fluorine containing compounds was selected by a computational method, developed to generate molecular diversity. These compounds were screened for Aβo binding by a combined 19F and STD NMR technique. Six hits were evaluated in three parallel biochemical and functional assays. Two compounds disrupted Aβo binding to its receptor PrPC in HEK293 cells. They reduced the pFyn levels triggered by Aβo treatment in neuroprogenitor cells derived from human induced pluripotent stem cells (hiPSC). Inhibitory effects on pTau production in cortical neurons derived from hiPSC were also observed. These drug-like compounds connect three of the pillars in Alzheimer's disease pathology, i.e. prion, Aβ and Tau, affecting three different pathways through specific binding to Aβo and are, indeed, promising candidates for further development

Vascular Remodeling in Health and Disease

The term vascular remodeling is commonly used to define the structural changes in blood vessel geometry that occur in response to long-term physiologic alterations in blood flow or in response to vessel wall injury brought about by trauma or underlying cardiovascular diseases.1, 2, 3, 4 The process of remodeling, which begins as an adaptive response to long-term hemodynamic alterations such as elevated shear stress or increased intravascular pressure, may eventually become maladaptive, leading to impaired vascular function. The vascular endothelium, owing to its location lining the lumen of blood vessels, plays a pivotal role in regulation of all aspects of vascular function and homeostasis.5 Thus, not surprisingly, endothelial dysfunction has been recognized as the harbinger of all major cardiovascular diseases such as hypertension, atherosclerosis, and diabetes.6, 7, 8 The endothelium elaborates a variety of substances that influence vascular tone and protect the vessel wall against inflammatory cell adhesion, thrombus formation, and vascular cell proliferation.8, 9, 10 Among the primary biologic mediators emanating from the endothelium is nitric oxide (NO) and the arachidonic acid metabolite prostacyclin [prostaglandin I2 (PGI2)], which exert powerful vasodilatory, antiadhesive, and antiproliferative effects in the vessel wall

The robustness of resource allocations in parallel and distributed computing systems

Abstract. This corresponds to the material in the invited keynote presentation by H. J. Siegel, summarizing the research in [2, 23]. Resource allocation decisions in heterogeneous parallel and distributed computer systems and associated performance prediction are often based on estimated values of application and system parameters, whose actual values are uncertain and may be differ from the estimates. We have designed a model for deriving the degree of robustness of a resource allocation—the maximum amount of collective uncertainty in parameters within which a user-specified level of system performance can be guaranteed. The model will be presented, and we will demonstrate its ability to select the most robust resource allocation from among those that otherwise perform similarly (based on the primary performance criterion). We will show how the model can be used in off-line allocation heuristics to maximize the robustness of makespan against inaccuracies in estimates of application execution times in a cluster.

Origin of two extreme solar particle events

Abstract We performed an analysis of high-energy particle emission from the Sun in two extreme solar particle events observed even with ground-based neutron monitors (NMs). We model particle transport and interactions from near-Sun source through the solar wind and the Earth’s magnetosphere and atmosphere in order to make a deep analysis of the events. The time profile of the proton source at the Sun is deduced and compared with observed electromagnetic emissions. Several complementary to each other data sets are studied jointly with the broadband dynamic radio spectra, EUV images as well as other data available for both events. We find a common scenario for both eruptions, including the flare’s dual impulsive phase, the coronal mass ejection (CME)-launch-associated burst and the late low-frequency type III radio bursts at the time of the relativistic proton injection into the interplanetary medium. The analysis supports the idea that the two considered events start with emission of relativistic protons previously accelerated during the flare and CME launch, then trapped in large-scale magnetic loops and later released by the expanding CME