Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers

Purpose To determine whether adjuvant tamoxifen treatment for breast cancer (BC) is associated with reduced contralateral breast cancer (CBC) risk for BRCA1 and/or BRCA2 mutation carriers. Methods Analysis of pooled observational cohort data, self-reported at enrollment and at follow-up from the International BRCA1, and BRCA2 Carrier Cohort Study, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, and Breast Cancer Family Registry. Eligible women were BRCA1 and BRCA2 mutation carriers diagnosed with unilateral BC since 1970 and no other invasive cancer or tamoxifen use before first BC. Hazard ratios (HRs) for CBC associated with tamoxifen use were estimated using Cox regression, adjusting for year and age of diagnosis, country, and bilateral oophorectomy and censoring at contralateral mastectomy, death, or loss to follow-up. Results Of 1,583 BRCA1 and 881 BRCA2 mutation carriers, 383 (24%) and 454 (52%), respectively, took tamoxifen after first BC d

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Not AvailableEleven insecticides including a new insecticide sulfoxaflor 24SC and standard insecticide monocrotophos 36SL were evaluated in the field against yellow stem borer and rice gundhi bug during wet season of 2011 and 2012. Plots treated with imidacloprid 17.8 SL @ 500 g a.i. ha−1 recorded lowest (3.6%) dead heart (DH), 3.6% white ear head (WEH), 6.5% grain damage due to gundhi bug and highest grain yield i.e., 5.18 t ha −1 in cv Jaya followed by sulfoxaflor 24 SC @ 90 g a.i. ha−1 (4.61 t ha−1), thiamethoxam 25WG@ 25 g a.i. ha−1 (4.58 t ha−1) and triazophos 40EC @ 450 g a.i. ha−1 (4.56 t ha−1) during 2011. Similar trend was also observed in 2012. During both the years, all the insecticides significantly reduced stem borer and gundhi bug damage over control. The standard insecticide monocrotophos 36SL@500 g a.i. ha −1 was found superior to the new insecticide sulfoxaflor 24SC at lower dose i.e. 75 g a.i. ha−1 against yellow stem borer and gundhi bug damage.Not Availabl

Evaluation of promising cashew hybrids for higher nut yield

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