10,672 research outputs found
Kinetic Monte Carlo simulation of the nitridation of the GaAs (100) surfaces
We present, in this work, our preliminary results of a systematic theoretical
study of the adsorption of N over As-terminated GaAs (100) (21)
surfaces. We analyzed the changes in the bond-lenghts, bond-angles and the
energetics involved before and after deposition. Our results show that the
N-atoms will prefer the unoccupied sites of the surface, close to the As dimer.
The presence of the N pushes the As dimer out of the surface, leading to the
anion exchange between the N and As atoms. Based on our results, we discussed
about the kinetics of the N islands formation during epitaxial growth of the
III-Nitrides.Comment: 4 pages, 7 figures, accepted for publication in Braz. J. Phys.,
special number, Proceedings of BWSP-12, 12th Brazilian Workshop on
Semiconductor Physic
Fisher matrix forecasts for astrophysical tests of the stability of the fine-structure constant
We use Fisher Matrix analysis techniques to forecast the cosmological impact
of astrophysical tests of the stability of the fine-structure constant to be
carried out by the forthcoming ESPRESSO spectrograph at the VLT (due for
commissioning in late 2017), as well by the planned high-resolution
spectrograph (currently in Phase A) for the European Extremely Large Telescope.
Assuming a fiducial model without variations, we show that ESPRESSO
can improve current bounds on the E\"{o}tv\"{o}s parameter---which quantifies
Weak Equivalence Principle violations---by up to two orders of magnitude,
leading to stronger bounds than those expected from the ongoing tests with the
MICROSCOPE satellite, while constraints from the E-ELT should be competitive
with those of the proposed STEP satellite. Should an variation be
detected, these measurements will further constrain cosmological parameters,
being particularly sensitive to the dynamics of dark energy.Comment: Phys. Lett. B (in press
Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA is synthesised from L-kynurenine by kynurenine aminotransferases (KAT) I and II. A host of immune mediators influence tryptophan degradation. In the present study, the levels of KYNA in cerebrospinal fluid (CSF) and serum in a group of human subjects aged between 25 and 74 years were determined by using a high performance liquid chromatography method. In CSF and serum KAT I and II activities were investigated by radioenzymatic assay, and the levels of Ī²2-microglobulin, a marker for cellular immune activation, were determined by ELISA. The correlations between neurochemical and biological parameters were evaluated. Two subject groups with significantly different ages, i.e. 50 years, p < 0.001, showed statistically significantly different CSF KYNA levels, i.e. 2.84 Ā± 0.16 fmol/Ī¼l vs. 4.09 Ā± 0.14 fmol/Ī¼l, p < 0.001, respectively; but this difference was not seen in serum samples. Interestingly, KYNA is synthesised in CSF principally by KAT I and not KAT II, however no relationship was found between enzyme activity and ageing. A positive relationship between CSF KYNA levels and age of subjects indicates a 95% probability of elevated CSF KYNA with ageing (R = 0.6639, p = 0.0001). KYNA levels significantly correlated with IgG and Ī²2-microglobulin levels (R = 0.5244, p = 0.0049; R = 0.4253, p = 0.043, respectively). No correlation was found between other biological parameters in CSF or serum. In summary, a positive relationship between the CSF KYNA level and ageing was found, and the data would suggest age-dependent increase of kynurenine metabolism in the CNS. An enhancement of CSF IgG and Ī²2-microglobulin levels would suggest an activation of the immune system during ageing. Increased KYNA metabolism may be involved in the hypofunction of the glutamatergic and/or nicotinic cholinergic neurotransmission in the ageing CNS
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