Complete gate control of supercurrent in graphene p-n junctions

In a conventional Josephson junction of graphene, the supercurrent is not turned off even at the charge neutrality point, impeding further development of superconducting quantum information devices based on graphene. Here we fabricate bipolar Josephson junctions of graphene, in which a p-n potential barrier is formed in graphene with two closely spaced superconducting contacts, and realize supercurrent ON/OFF states using electrostatic gating only. The bipolar Josephson junctions of graphene also show fully gate-driven macroscopic quantum tunnelling behaviour of Josephson phase particles in a potential well, where the confinement energy is gate tuneable. We suggest that the supercurrent OFF state is mainly caused by a supercurrent dephasing mechanism due to a random pseudomagnetic field generated by ripples in graphene, in sharp contrast to other nanohybrid Josephson junctions. Our study may pave the way for the development of new gate-tuneable superconducting quantum information devices.open114344sciescopu

Distinctive Genetic Activity Pattern of the Human Dental Pulp between Deciduous and Permanent Teeth

published_or_final_versio

On the coherency of dynamic load estimates for vehicles on flexible structures

This paper develops a novel form of a well-known signal processing technique, so as to be applicable to the interaction between a heavy truck and a supporting bridge structure. Motivated by the problem of structural health monitoring of bridges, a new modal coherency function is defined. This relates the input action of moving wheel loads to the dynamic response of the bridge, including the effects of unevenness of the road surface and the vertical dynamics of the truck suspension. The analysis here is specifically aimed at future experimental testing – the validation of axle load estimators obtained from sensors on the truck. It is applicable even when no independent ‘ground truth’ for the dynamic loads is available. The approach can be more widely used in the analysis of dynamic interactions involving suspended moving loads on deformable structures, e.g. for structural vibrations due to high-speed train

Temporal and Spatial Expression Patterns of miR-302 and miR-367 During Early Embryonic Chick Development

published_or_final_versio

Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine.

In rats, FK significantly prolonged heterotopic heart graft survival over a wide dose range when given for 2 weeks starting on the day of the operation. Brief courses of FK for one to four days preoperatively, and especially beginning four days postoperatively, allowed long subsequent survival of heart grafts in otherwise untreated recipients. The seeming acceptance of the grafts with postoperative FK treatment was largely but not exclusively donor specific when tested eight days after the last FK dose by second grafts from the same donor v third-party donor grafts. FK in minimally therapeutic doses was synergistic with suboptimal doses of CyA

Effect of alkalinity and calcium concentration of pore solution on the swelling and ionic exchange of superabsorbent polymers in cement paste

Swelling kinetics of superabsorbent polymers (SAP) in fresh concrete is complex, but its understanding is crucial for optimisation in practical applications. In this study, the effect of concentration of ions common in pore solution (Na+, K+, Ca2+, Cl−, OH−, SO42−) and cyclic wetting/drying on the swelling and ionic exchange of poly(AA) and poly(AA-co-AM) were investigated. Results show that swelling is not a simple function of concentration or ionic strength. In cement paste, SAP absorbs Ca2+ and releases its counterion (Na+, K+) into pore solution. Ca2+ binds with SAP and decreases initial swelling, but the bound Ca2+ can be displaced and swelling gradually recovers. Swelling increases with increase in alkalinity, but decreases with increase in calcium concentration. The higher the degree of ion exchange, the lower the swelling of SAP. Poly(AA) is more susceptible to Ca2+ complexation and therefore achieves a lower swelling ratio and slower swelling recovery compared to poly(AA-co-AM)

Comparing Results of Five Glomerular Filtration Rate-Estimating Equations in the Korean General Population. MDRD Study, Revised Lund-Malmö, and Three CKD-EPI Equations

Estimated glomerular filtration rate (eGFR) is a widely used index of kidney function. Recently, new formulas such as the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations or the Lund-Malmö equation were introduced for assessing eGFR. We compared them with the Modification of Diet in Renal Disease (MDRD) Study equation in the Korean adult population. METHODS: The study population comprised 1,482 individuals (median age 51 [42-59] yr, 48.9% males) who received annual physical check-ups during the year 2014. Serum creatinine (Cr) and cystatin C (CysC) were measured. We conducted a retrospective analysis using five GFR estimating equations (MDRD Study, revised Lund-Malmö, and Cr and/or CysC-based CKD-EPI equations). Reduced GFR was defined as eGFR <60 mL/min/1.73 m². RESULTS: For the GFR category distribution, large discrepancies were observed depending on the equation used; category G1 (≥90 mL/min/1.73 m²) ranged from 7.4-81.8%. Compared with the MDRD Study equation, the other four equations overestimated GFR, and CysC-based equations showed a greater difference (-31.3 for CKD-EPI(CysC) and -20.5 for CKD-EPI(Cr-CysC)). CysC-based equations decreased the prevalence of reduced GFR by one third (9.4% in the MDRD Study and 2.4% in CKD-EPI(CysC)). CONCLUSIONS: Our data shows that there are remarkable differences in eGFR assessment in the Korean population depending on the equation used, especially in normal or mildly decreased categories. Further prospective studies are necessary in various clinical settings