SyncDiffusion: Coherent Montage via Synchronized Joint Diffusions

The remarkable capabilities of pretrained image diffusion models have been utilized not only for generating fixed-size images but also for creating panoramas. However, naive stitching of multiple images often results in visible seams. Recent techniques have attempted to address this issue by performing joint diffusions in multiple windows and averaging latent features in overlapping regions. However, these approaches, which focus on seamless montage generation, often yield incoherent outputs by blending different scenes within a single image. To overcome this limitation, we propose SyncDiffusion, a plug-and-play module that synchronizes multiple diffusions through gradient descent from a perceptual similarity loss. Specifically, we compute the gradient of the perceptual loss using the predicted denoised images at each denoising step, providing meaningful guidance for achieving coherent montages. Our experimental results demonstrate that our method produces significantly more coherent outputs compared to previous methods (66.35% vs. 33.65% in our user study) while still maintaining fidelity (as assessed by GIQA) and compatibility with the input prompt (as measured by CLIP score).Comment: Project page: https://syncdiffusion.github.i

Analysis of cattle olfactory subgenome: the first detail study on the characteristics of the complete olfactory receptor repertoire of a ruminant

BACKGROUND: Mammalian olfactory receptors (ORs) are encoded by the largest mammalian multigene family. Understanding the OR gene repertoire in the cattle genome could lead to link the effects of genetic differences in these genes to variations in olfaction in cattle. RESULTS: We report here a whole genome analysis of the olfactory receptor genes of Bos taurus using conserved OR gene-specific motifs and known OR protein sequences from diverse species. Our analysis, using the current cattle genome assembly UMD 3.1 covering 99.9% of the cattle genome, shows that the cattle genome contains 1,071 OR-related sequences including 881 functional, 190 pseudo, and 352 partial OR sequences. The OR genes are located in 49 clusters on 26 cattle chromosomes. We classified them into 18 families consisting of 4 Class I and 14 Class II families and these were further grouped into 272 subfamilies. Comparative analyses of the OR genes of cattle, pigs, humans, mice, and dogs showed that 6.0% (n = 53) of functional OR cattle genes were species-specific. We also showed that significant copy number variations are present in the OR repertoire of the cattle from the analysis of 10 selected OR genes. CONCLUSION: Our analysis revealed the almost complete OR gene repertoire from an individual cattle genome. Though the number of OR genes were lower than in pigs, the analysis of the genetic system of cattle ORs showed close similarities to that of the pig

Characterization of Cronobacter sakazakii Strains Originating from Plant-Origin Foods Using Comparative Genomic Analyses and Zebrafish Infectivity Studies

Cronobacter sakazakii continues to be isolated from ready-to-eat fresh and frozen produce, flours, dairy powders, cereals, nuts, and spices, in addition to the conventional sources of powdered infant formulae (PIF) and PIF production environments. To understand the sequence diversity, phylogenetic relationship, and virulence of C. sakazakii originating from plant-origin foods, comparative molecular and genomic analyses, and zebrafish infection (ZI) studies were applied to 88 strains. Whole genome sequences of the strains were generated for detailed bioinformatic analysis. PCR analysis showed that all strains possessed a pESA3-like virulence plasmid similar to reference C. sakazakii clinical strain BAA-894. Core genome analysis confirmed a shared genomic backbone with other C. sakazakii strains from food, clinical and environmental strains. Emerging nucleotide diversity in these plant-origin strains was highlighted using single nucleotide polymorphic alleles in 2000 core genes. DNA hybridization analyses using a pan-genomic microarray showed that these strains clustered according to sequence types (STs) identified by multi-locus sequence typing (MLST). PHASTER analysis identified 185 intact prophage gene clusters encompassing 22 different prophages, including three intact Cronobacter prophages: ENT47670, ENT39118, and phiES15. AMRFinderPlus analysis identified the CSA family class C β-lactamase gene in all strains and a plasmid-borne mcr-9.1 gene was identified in three strains. ZI studies showed that some plant-origin C. sakazakii display virulence comparable to clinical strains. Finding virulent plant-origin C. sakazakii possessing significant genomic features of clinically relevant STs suggests that these foods can serve as potential transmission vehicles and supports widening the scope of continued surveillance for this important foodborne pathogen

Counseling Psychological Understanding and Considerations of the Metaverse: A Theoretical Review

The COVID-19 pandemic has triggered the interest in and demand for online platforms that can replace traditional face-to-face activities. Accordingly, metaverses have been increasingly used across society, especially in the Mental health field. This broad use of metaverses is now recognized as a major trend that will drive various industries across healthcare and society. In response to this societal change, this study provides a theoretical framework for understanding and applying metaverses as therapeutic spaces in mental health fields through a conceptualization and characterization of metaverses for a range of technologies and services. The value of metaverses as a human-centered “field of experience” was identified and proposed based on the essential aspect of the user, the human being, rather than from the technology used. According to existing psychotherapeutic theories, four therapeutic concepts for the metaverse were proposed: metaverse as an “average expectable environment” in the developmental and therapeutic categories of the self, a transitional stage for adaptation to reality, a creative space for memory and communication for the self, and an expanded or “surplus” reality. This work is expected to be a useful basis for expanding new psychotherapeutic strategies and methods as therapeutic spaces for maintaining mental health through the metaverse

Influence of Religious Practice and Church Interpersonal Trust on Spiritual Experience during COVID-19 Pandemic

The COVID-19 pandemic not only increased the risk of poor physical health but also brought about a crisis of spiritual health through restrictions on worship services. This study examined the spiritual health of Christians living in the era of COVID-19 and analyzed the role of personal religious practice and interpersonal trust in the church. To this end, 600 Christian adults were surveyed. This study found that women’s spiritual experience was higher than men’s and tended to be higher with older age and the length of faith. These results were linked to church duties, as duty holders had more spiritual experience than laypersons. Regarding individual religious practice and interpersonal trust, the group who frequently prayed and read the Bible and the group with high interpersonal trust in the church had high daily spiritual experiences, respectively. A comprehensive analysis through decision tree analysis showed that prayer was the variable showing the greatest difference in daily spiritual experience, while Bible reading was the second most important personal religious activity. Regarding church interpersonal trust, interaction-based trust and institution-based trust contributed to enhancing personal spiritual experience. Personal religious practice was reported as a more important variable in the promotion of spiritual experience than interpersonal factors during COVID-19

Effects of the Fear of COVID-19 and Efficacy of Coping Behavior for Infectious Diseases after the End of COVID-19: Moderating Effects of Cyberchondria and eHealth Literacy

As the coronavirus disease (COVID-19) pandemic ends, it is worth considering whether the ability to cope with such a pandemic has improved. The initial response to COVID-19 was hampered by the fear of new infectious diseases and spread of misinformation on the Internet. This highlights the need to enhance our ability to critically evaluate information rather than indiscriminately search for and trust information on the Internet. Therefore, this study examined how cyberchondria and eHealth literacy moderate the effect of fear of COVID-19 on the efficacy of coping behaviors for future epidemics and pandemics. The participants were 1000 adults in South Korea who were selected based on population proportionality. The results showed that fear of COVID-19 was significantly positively related to cyberchondria, and eHealth literacy was significantly positively related to the efficacy of coping behaviors. Further, the fear of COVID-19 had a significantly negative effect on the efficacy of coping behaviors, and the moderating effect of cyberchondria varied according to the level of eHealth literacy. These results emphasize the importance of eHealth literacy in enabling critical decision-making regarding misinformation

Consideration of the Psychological and Mental Health of the Elderly during COVID-19: A Theoretical Review

COVID-19 has spread worldwide causing an unprecedented public health crisis. After the World Health Organization declared a pandemic in March 2020, the number of confirmed cases and deaths has continued to increase. This situation may be prolonged until an effective, tested, and safe treatment is available. COVID-19 can occur at any age. However, the maximum confirmed cases and deaths have occurred among the elderly. Particularly, the mental and physical health of the elderly aged above 60 and classified as high-risk groups is more vulnerable than other age groups, requiring more attention. Strong social restraint, social distancing, and quarantine measures to prevent the COVID-19 spread have raised concerns about their mental health. Therefore, it is crucial to analyze and identify the psychological concepts and protective factors that support and constitute these guidelines and strategies and prepare practical suggestions and guidelines to protect the mental health of the elderly during COVID-19. These discussions will facilitate a deeper understanding and expansion of these guidelines and strategies. Therefore, this study explores factors—including pandemic-induced stress, self-integration, self-efficacy, and resilience—in order to prepare practical and detailed suggestions and guidelines using studies that considered these factors, including coping with COVID-19-induced stress, social support, and physical activity