Amino acid profiles in older adults with frailty. Secondary analysis from MetaboFrail and BIOSPHERE studies

An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S, n = 94), frail/pre-frail older adults with type 2 diabetes mellitus (F-T2DM, n = 66), and robust non-diabetic controls (n = 40). Partial least squares discriminant analysis (PLS–DA) models were built to define the amino acid signatures associated with the different frailty phenotypes. PLS–DA allowed correct classification of participants with 78.2 ± 1.9% accuracy. Older adults with F-T2DM showed an amino acid profile characterized by higher levels of 3-methylhistidine, alanine, arginine, ethanolamine, and glutamic acid. PF&S and control participants were discriminated based on serum concentrations of aminoadipic acid, aspartate, citrulline, cystine, taurine, and tryptophan. These findings suggest that different types of frailty may be characterized by distinct metabolic perturbations. Amino acid profiling may therefore serve as a valuable tool for frailty biomarker discovery

Using the HOME Inventory with Infants in Costa Rica

This study determined the psychometric properties of the HOME (Home Observation for Measurement of the Environment) Inventory in a Latin American sample. HOME data for 183 healthy Costa Rican infants were compared to the original HOME standardisation sample from Little Rock. The Costa Rican total HOME average of 29.8 ± 6.7 was similar to the scores of families in Little Rock (mean = 31.2 ± 7.3). Measures or internal consistency and factor structure were similar in US and Costa Rican samples. In contrast to these similarities, Costa Rican HOME scores showed no significant correlation with developmental test scores in infancy (Bayley MDI), and the correlation with Full Scale IQ (WPPSI) at five years was modest, albeit statistically significant (r = 0.28, P < 0.05). These relationships were similar to those of Mexican-American children in a recent collaborative study by Bradley et al., 1989 and not as strong as for US white and black populations. However, when the concept of outcome was broadened beyond IQ scores to include child health and development in general, the HOME seemed sensitive to important environmental differences in this Costa Rican group. Lower HOME scores related to a shorter duration of breastfeeding and differentiated children with iron deficiency anaemia in infancy, a condition associated with long-lasting developmental disadvantage. Thus, the HOME was helpful in identifying children at risk for delayed development in this Latin American sample.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67767/2/10.1177_016502549501800206.pd

Social Support, Parental Belief Systems, and Well Being

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68416/2/10.1177_0044118X89021001006.pd