25 research outputs found
Π¦ΠΠ’ΠΠΠΠΠΠ§ΠΠ‘ΠΠΠ ΠΠΠΠΠΠΠ’ΠΠΠ ΠΠ ΠΠΠ₯ΠΠΠΠ¬ΠΠΠΠΠ―Π ΠΠΠΠ ΠΠΠΠΠΠ Π ΠΠ¦ΠΠΠΠ Π₯ΠΠ ΠΠΠ’ΠΠ Π Π’ΠΠ§ΠΠΠΠ― ΠΠΠΠΠΠΠΠΠΠΠ ΠΠΠΠΠ ΠΠΠ§ΠΠ‘ΠΠΠΠ ΠΠΠ¬ΠΠΠΠΠΠ’Π
Application of complex of modern cytologic methods of research bronchoalveolar lavage allowed to allocate most characteristics of development of lymphocytic and macrophagic reaction of bronchial tree in different course of exogenous allergic alveolitis. The most indicative in assessment of origin of exogenous allergic alveolitis development is the characteristics of macrophagic population. In acute course of exogenous allergic alveolitis the considerable number of young activated and non-activated macrophages, increased number of mature phagocytes is observed. Even more significant increase of phagocytic macrophages is observed at dissemination which is primarily is connected with participation of these cells in lymphocytic apoptosis which takes place in high percentage of lymphocytes (up to 49%). Increased number of mature phagocytes is observed at chronic course of exogenous allergic alveolitis that is an important diagnostic pattern of this option of development of exogenous allergic alveolitis in association with the lowest T-helpers/T-supressors index.Β ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠΎΠ½Ρ
ΠΎΠ°Π»ΡΠ²Π΅ΠΎΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΌΡΠ²Π° ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ Π²ΡΠ΄Π΅Π»ΠΈΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠΉ ΠΈ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³Π°Π»ΡΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π° ΠΏΡΠΈ ΡΠ°Π·Π½ΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π»ΡΠ²Π΅ΠΎΠ»ΠΈΡΠ°. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΡΠΌ Π² ΠΎΡΠ΅Π½ΠΊΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° Π΅Π³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³Π°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ. ΠΡΠΈ ΠΎΡΡΡΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°ΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΡΠΈΡΠ»ΠΎ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΈ Π½Π΅Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ², ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π·ΡΠ΅Π»ΡΡ
ΡΠ°Π³ΠΎΡΠΈΡΠΎΠ². ΠΡΠ΅ Π±ΠΎΠ»Π΅Π΅ Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠ»Π° ΡΠ°Π³ΠΎΡΠΈΡΠΈΡΡΡΡΠΈΡ
ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ² ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΡΡ ΠΏΡΠΈ ΠΏΠΎΠ΄ΠΎΡΡΡΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΡΠΎ Π² ΠΏΠ΅ΡΠ²ΡΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ ΡΡΠΈΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π² Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠΌ Π°ΠΏΠΎΠΏΡΠΎΠ·Π΅, ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ Π² ΡΡΠΎΡ ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π²ΡΡΠΎΠΊΠ° (Π΄ΠΎ 49%). ΠΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π·ΡΠ΅Π»ΡΡ
ΡΠ°Π³ΠΎΡΠΈΡΠΎΠ² Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΈ ΠΏΡΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π»ΡΠ²Π΅ΠΎΠ»ΠΈΡΠ°, ΡΡΠΎ, Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΡΠ°ΠΌΡΠΌΠΈ Π½ΠΈΠ·ΠΊΠΈΠΌΠΈ Π²Π΅Π»ΠΈΡΠΈΠ½Π°ΠΌΠΈ ΠΈΠ½Π΄Π΅ΠΊΡΠ° Π’Β Ρ
Π΅Π»ΠΏΠ΅ΡΡ/Π’Β ΡΡΠΏΡΠ΅ΡΡΠΎΡΡ, ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π°ΠΆΠ½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠΌ ΡΡΠΎΠ³ΠΎ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π±ΠΎΠ»Π΅Π·Π½ΠΈ.
ΠΠΈΡΠ±Π°Π»Π°Π½Ρ ΡΠΈΠ½ΠΊΠ° ΠΈ ΠΌΠ΅Π΄ΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ Π΄Π΅ΡΠΈΡΠΈΡΠ° Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΠΈ Π³ΠΈΠΏΠ΅ΡΠ°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ
The objective of the study was investigation of serum zinc (Zn) and copper (Cu) levels in blood serum, urine, and hair of preschool and primary school aged children with attention deficit/hyperactivity (ADHD) syndrome. A total of 50 children aged 4-9 y.o. with ADHD as well as 50 neurotypical controls were involved in the study. Assessment of serum Zn and Cu levels was performed using ICP-MS. It is demonstrated that children with ADHD are characterized by a significant 8% ( p = 0.001) decrease in serum Zn levels. In the case of hair, copper levels were 16% ( p = 0.039) lower than the control values. Urinary metal concentrations were relatively stable. Serum Cu/Zn ratio in ADHD exceeded the control values by 12% ( p = 0.003). The observed 15% decrease in urinary Cu/Zn ratio was nearly significant ( p = 0.080), being indicative of predominant increase in zinc excretion in comparison to copper. In regression models adjusted for age, gender, body weight and height, hair Zn ( Ξ² = -0.277; p = 0.027) and Cu/Zn ratio ( Ξ² = -0.536; p = 0.008), as well as urinary Zn levels ( Ξ² = 0.418; p = 0.049) were significantly associated with ADHD. Therefore, the obtained data indicate the potential role of zinc deficiency in ADHD, with increased zinc loss being considered as the potential factor leading to reduced Zn status.Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ ΡΠΈΠ½ΠΊΠ° ΠΈ ΠΌΠ΅Π΄ΠΈ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ, ΠΌΠΎΡΠ΅ ΠΈ Π²ΠΎΠ»ΠΎΡΠ°Ρ
Π΄Π΅ΡΠ΅ΠΉ Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ Π΄Π΅ΡΠΈΡΠΈΡΠ° Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΠΈ Π³ΠΈΠΏΠ΅ΡΠ°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ (Π‘ΠΠΠ) Π΄ΠΎΡΠΊΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΡΠ°Π½Π½Π΅Π³ΠΎ ΡΠΊΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΈΠ½ΡΠ»ΠΈ ΡΡΠ°ΡΡΠΈΠ΅ 50 Π΄Π΅ΡΠ΅ΠΉ Ρ Π‘ΠΠΠ (4-9 Π»Π΅Ρ), Π° ΡΠ°ΠΊΠΆΠ΅ 50 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ. ΠΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠΈΠ½ΠΊΠ° ΠΈ ΠΌΠ΅Π΄ΠΈ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ, ΠΌΠΎΡΠ΅ ΠΈ Π²ΠΎΠ»ΠΎΡΠ°Ρ
ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ Ρ ΠΈΠ½Π΄ΡΠΊΡΠΈΠ²Π½ΠΎ-ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠΉ ΠΏΠ»Π°Π·ΠΌΠΎΠΉ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π΄Π΅ΡΠΈ, ΡΡΡΠ°Π΄Π°ΡΡΠΈΠ΅ Π‘ΠΠΠ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠΌ 8% ( p = 0,001) ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠΎΠ²Π½Ρ ΡΠΈΠ½ΠΊΠ° Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ. Π£ΡΠΎΠ²Π΅Π½Ρ ΠΌΠ΅Π΄ΠΈ Π² Π²ΠΎΠ»ΠΎΡΠ°Ρ
Π΄Π΅ΡΠ΅ΠΉ Ρ Π‘ΠΠΠ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π»ΡΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠΌ 16% ( p = 0,039) ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ. Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² Π² ΠΌΠΎΡΠ΅ ΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΠΌ. ΠΠ½Π°ΡΠ΅Π½ΠΈΡ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ Cu/Zn Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π‘ΠΠΠ ΠΏΡΠ΅Π²ΡΡΠ°Π»ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π½Π° 12% ( p = 0,003). ΠΠ°Π±Π»ΡΠ΄Π°Π΅ΠΌΠΎΠ΅ 15%-Π½ΠΎΠ΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ Cu/Zn Π² ΠΌΠΎΡΠ΅ ΠΏΡΠΈΠ±Π»ΠΈΠΆΠ°Π»ΠΎΡΡ ΠΊ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠΌΡ ( p = 0,080), ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ ΡΠ²Π»ΡΡΡΡΡ ΠΎΡΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠΈ ΡΠΈΠ½ΠΊΠ° ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΌΠ΅Π΄ΡΡ. Π ΡΠ΅Π³ΡΠ΅ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΏΠΎΠΏΡΠ°Π²ΠΊΠΈ Π½Π° Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΠΎΠ»Π°, Π²ΠΎΠ·ΡΠ°ΡΡΠ°, ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° ΠΈ ΡΠΎΡΡΠ° Π΄Π΅ΡΠ΅ΠΉ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΠΈΠ½ΠΊΠ° ( Ξ² = -0,277; p = 0,027) ΠΈ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ Cu/Zn ( Ξ² = -0,536; p = 0,008) Π² Π²ΠΎΠ»ΠΎΡΠ°Ρ
, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΠΎΠ²Π΅Π½Ρ Zn Π² ΠΌΠΎΡΠ΅ ( Ξ² = 0,418; p = 0,049) Π±ΡΠ»ΠΈ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ²ΡΠ·Π°Π½Ρ Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π‘ΠΠΠ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΊΠ°Π·ΡΠ²Π°ΡΡ Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ ΡΠΎΠ»Ρ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΡΠΈΠ½ΠΊΠ° Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π‘ΠΠΠ, ΠΏΡΠΈΡΠ΅ΠΌ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΏΡΠΈΡΠΈΠ½ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΌΠΎΠΆΠ΅Ρ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΈΠ½ΡΠ΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠΈ ΠΌΠ΅ΡΠ°Π»Π»Π°