Acute Rhinosinusitis in Children in the Practice of General Practitioners and Rational Antibiotic Treatment in its Bacterial Origin

In order to determine the precise diagnostic criteria of bacterial origin for acute lesions of the nose and paranasal sinuses in children and the rationale for prescribing antibiotics to improve the effectiveness of treatment by general practitioners and pediatricians on the first and second stages of medical care the authors have analyzed a number of literary sources. It is found that, in accordance with the 2012 EPOS guidelines amoxicillin without the addition of beta- lactamase inhibitors is no longer considered as an effective drug for the treatment of acute bacterial rhinosinusitis, treatment is recommended to start with administration of amoxicillin/clavulanate in mean therapeutic doses. We also concluded that the domestic approach to etiotropic treatment of acute bacterial rhinosinusitis in children is close to the international guidelines, but there is still the need to update national guidelines

Arthritis in primary immunodeficiencies

The article deals with joint diseases in patients with primary immunodeficiencies. The analysis of the li­terature data based on Scopus, Science Index, Google Scholar, PubMed databases accentuated primary immunodeficiencies associated with the joint damage. Arthritis in patients with primary immunodeficiencies can be septic or aseptic. Chronic autoimmune arthritis with the development of destructive changes in the joint in these patients is always a challenge for the physicians and causes difficulties in the diagnosis and treatment, requires a careful approach to treatment