Development of the New Method of the Melted Cheese Products Without Salt-melters Using Cryomechanolysis

The aim of the work is elaboration of the principally new method of deep processing of rennet cheeses to the melting using the complex action of freezing and cryomechanolysis on the raw material that gives a possibility to destruct the hardly soluble biopolymers and to transform them into soluble form.The principally new method of the deep processing of rennet cheeses for receiving the melt cheese products without salts-smelters was elaborated. It differs from the traditional ones by the complete exclusion of the salts-smelters. This method is based on the use of the influence of freezing and fine-dispersed comminution on the raw material. It allows open biological potential of the rennet cheeses more fully and to extract the hidden (bound) protein forms from nanocomplexes of lipids and mineral substances. It allows destruct the proteins of rennet cheeses to the separate polymers and dipeptides and tripeptides. The used technological methods gave a possibility to exclude the salts-smelters at the rennet cheeses manufacturing. They favor the transformation of lipid-proteins paracaseinate calcium phosphate complexes to the separate amino acids and peptides and allow receive homogenous plastic mass.It was established, that at the complex action of freezing and fine-dispersed comminution on the rennet cheese the destruction of hardly soluble lipid-protein nanocomplexes and release of protein from the bound state into free one – nanoform (by 33,5…35 % more) takes place. The mechanisms of this process, connected with cryomechanodestruction of connections between lipids and proteins and non-fermented catalysis of nanocomplexes were described.It was established, that cryomechanodestruction and non-fermented catalysis of protein to the separate monomers – α-amino acids (by 55…60 %) takes place at freezing and fine-dispersed comminution of rennet cheese before melting. The mechanism of freezing and non-fermented analysis, connected with cryomechanocracking of protein molecules at the expanse of peptide protein connections destruction to the separate α-amino acids and their transformation into the free form was described. It was also demonstrated, that the conformational changes of protein molecules take place synchronously.The offered and elaborated nanotechnology of melt cheese products on the base of rennet cheeses without salts-smelters includes complex action of freezing and fine-dispersed comminution. The mechanisms of processes, connected with cryomechanodestruction of connections between lipids and protein to the separate α-amino acids are described.The cheese fillings for “Pancake” confectionary and cheese snacks – falafels were manufactured on the base of cheese mass, received using the new method and enriching vegetable nanoadditives. They exceed the well-known analogs by chemical composition and are remarkable for the storage life, increased in 2 times. At the same time the significant part of substances (BAS and biopolymers) in cheese filings is in nanodimensional form (55…60 % of protein), especially, free α-amino acids, easily assimilated by the human organism. The recipes and technologies of sauces-dressings, sauces-deeps, cheese snacks and so on are also elaborated on the base of cheese mass, received by the new method

Influence of Diazepino [1,2-a] benzimidazole derivative (DAB-19) on behavioral aspects of animals

In the present study, compound DAB-19 was screened for its influence on animals` behavior patterns, such as aggression, obsessive-compulsive behavior, emotional lability, and unsociabilit

The technical asprcts of building station for the accreditation of the pharmacists at the department of management and economics of pharmasy ural state medical university

Key elements of the stations of the second stage of the initial accreditation pharmacists and equipping stations.В статье рассмотрены ключевые элементы станций второго этапа первичной аккредитации провизоров и оснащение станций

Marketing analysis of the range in the group of non-steroidal anti–inflammatory drugs in a segment of drugstores of Yekaterinburg

The article presents the data of marketing analysis NSAIDs range. Analyzed consumer behavior in this group of drugs. The recommendations for overcoming both the price and assortment unavailability of highly COX‑2 inhibitors.В статье изложены данные маркетингового анализа ассортимента НПВП. Проанализировано потребительское поведение в данной группе препаратов. Изложены рекомендации для преодоления как ценовой, так и ассортиментной недоступности высокоселективных ингибиторов ЦОГ‑2

Searching for novel antagonists of adenosine A1 receptors among azolo[1,5-a]pyrimidine nitro derivatives

Introduction: Ligands of adenosine A1Rs are potential candidates for the development of drugs for the treatment of paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart failure. At the same time, there is a deficiency of drugs that can regulate the functions of A1 receptors. A number of A1-antagonists are at the various stages of clinical trials; other drugs are not very selective or are characterized by an insufficient breadth of their therapeutic action. Therefore, the search for new medicinal compounds for the prevention and treatment of A1-depended diseases among nitro derivatives of tetrazolo[1,5-a]pyrimidine and 1,2,4-triazolo[1,5-a]pyrimidine is of scientific interest. Materials and methods: The search for active compounds was carried out by in silico and in vitro methods. At the first stage, a computer forecast of A1-antagonistic activity was carried out using the Microcosm BioS software. At the second stage, the prediction results were verified in vitro in a model of isolated mouse atria. Results and discussion: Based on the results of the prediction by the method of maximum similarity to standards, the most active compounds III, VIII, and XVII were selected. After testing the prediction results by the isolated atria method, the compound VIII was characterized by A1-blocking effect in vitro at a concentration of 10 μmol/L. Conclusion: The most promising compound with A1-blocking effect in vitro was identified; it is a derivative of tetrazolo[1,5-a]pyrimidine under the code of VIII. It is of interest for us for further in-depth study of its pharmacological properties. Copyright Yakovlev DS et al.The reported study was partially funded by the Gover

Prospects of implementing integrated information systems in the preferential drug provision of patients with copd on the territory of Sverdlovsk region

Analysis of prospects of implementation and functionality of information systems in preferential drug provision, a review of the regulatory framework in the system of preferential provision of medicines.Анализ перспективы внедрения и функциональных возможностей информационных систем в льготном лекарственном обеспечении, обзор нормативной базы в системе льготного лекарственного обеспечения

Особенности эпидемической и эпизоотической ситуации по рабической инфекции в Донецкой Народной Республике

Purpose: analysis of the epidemic situation of rabies infection in the territory of the Donetsk People's Republic and assessment of the level of epidemic threat for this infection for 2023. Materials and methods: A retrospective epidemiological analysis of the epidemic and epizootic situation of rabies infection was carried out based on the materials of the Department of Especially Dangerous Infections Republican Center for Sanitary and Epidemiological Surveillance of the State Sanitary and Epidemiological Service of the Ministry of Health of the Donetsk People's Republic for the last 8 years. Results: For the period from 2015 to March 2023 in the Donetsk People's Republic, 4 cases of rabies infection in people were registered (in 2016, 2021, 2022), which ended in death due to the untimely appeal of those bitten for specialized medical help. The epizootic situation for rabies infection remained unfavorable for the studied period of time. This infection has been laboratory confirmed in animals: 2015 — in 33 cases, 2016 — in 50 cases, 2017 — in 50 cases, 2018 — in 42 cases, 2019 — in 56 cases, 2020 — in 44 cases, 2021 — in 33 cases, 2022 — in 32 cases.Цель: анализ эпидемической и эпизоотической ситуаций по рабической инфекции на территории Донецкой Народной Республики и оценка уровня эпидемической угрозы по этой инфекции на 2023 г. Материалы и методы: Проведен ретроспективный эпидемиологический анализ эпидемической и эпизоотической ситуации по рабической инфекции по материалам отделения особо опасных инфекций Республиканского центра санитарно-эпидемиологического надзора государственной санитарно-эпидемиологической службы Министерства здравоохранения Донецкой Народной Республики за последние 8 лет.Результаты: За период с 2015 по март 2023 гг. в Донецкой Народной Республике было зарегистрировано 4 случая рабической инфекции у людей (в 2016 г., 2021 г., 2022 г.), которые завершились летальным исходом в связи с несвоевременным об- ращением укушенных за специализированной помощью. Эпизоотическая ситуация по рабической инфекции за исследуемый промежуток времени оставалась неблагополучной. Эта инфекция была подтверждена лабораторно у животных: в 2015 г. в 33 случаях, в 2016 г. — в 50 случаях, в 2017 г. — в 50 случаях, в 2018 г. — в 42 случаях, в 2019 г. — в 56 случаях, в 2020 г. — в 44 случаях, в 2021 г. — в 33 случаях, в 2022 г. — в 32 случаях

Клинические случаи рецидивирующей бубонной и легочной форм туляремии

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Electrodynamics of wave processes into two-connected planar wave guide structures

There are represented three configurations of two-connected planar wave-guides, two of them have small dissipations. We research theoretically and experimentally dependences of wave impedance, integration level and dissipations of proposed waveguides on their geometrical parameters and dielectric fulfillment structure. Obtained results for planar waveguide are represented and compared with results, correspondent to standard microstrip line researches