Possibilities of using branched-chain amino acids for the treatment and prevention of sarcopenia in elderly and old patients (literature review)

Due to the high prevalence of sarcopenia among elderly and old patients, early prevention and treatment of sarcopenia and its complications are relevant. Protein supplements can be used to maintain muscle strength and mass during aging. The possibility of using branched-chain amino acids (BCAAs) in the treatment and prevention of sarcopenia in geriatric patients is of scientific interest. BCAAs promote the synthesis and inhibit the degradation of muscle tissue proteins, are involved in the regulation of tissue sensitivity to insulin, ammonia utilization, the tricarboxylic acid cycle, etc.Search strategy. The search for scientific articles for literature review was carried out in the PubMed and PubMed Central databases. The selection criterion was scientific articles published up to December 2022. We used the following search keywords: “branched-chain amino acids”, “BCAA”, “body composition”, “sarcopenia”, “aging”. The 2019 European Working Group on Sarcopenia in Older People 2 (EWGSOP2) Consensus was included in the list of articles.Conclusions. The possibility of using BCAAs in elderly and old patients for the prevention and treatment of sarcopenia is a relevant topic that continues to be actively studied. The effectiveness of BCAA supplementation in the diet is debatable as long as sufficient protein is consumed daily. On the other hand, BCAA supplementation may be justified in cases where it is not possible to consume enough high-quality protein in the diet. More research is needed on this topic

Биазеотропия в трехфазных системах

Evolution of diagrams of biazeotropic three-phase mixture methyl tert-butyl ether - water at high pressure was considered.Рассмотрена эволюция диаграмм биазеотропной трехфазной смеси метил-трет-бутиловый эфир - вода при повышенном давлении

The role of sulfonylures in the treatment of type 2 diabetes

Type 2 diabetes mellitus (T2DM) is one of the most common diseases in the world accounting for about 85--90% of the total number of people with diabetes. More than 80% of these patients are overweight or obese, and lead sedentary lifestyles. If earlier T2DM was considered "a disease of the elderly", now half of patients suffering from the disease are people of working age. Reduced working ability as well as financial burden of prevention and treatment of late complications of DM are a significant problem for the healthcare system and society as a whole. At the same time, T2DM therapy involving effective medicines which are convenient and have minimum side effects could markedly reduce treatment costs

Biazeotropy in three-phase mixtures

Evolution of diagrams of biazeotropic three-phase mixture methyl tert-butyl ether - water at high pressure was considered

Phase composition of high strength binding material based on fine microspherical highcalcium fly ash material based on fine microspherical highcalcium fly ash

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.The combination of factors was established for using high-calcium fly ash (HCFA) as a binder material of high early and long-term strength: (1) high dispersity of microspherical HCFA, 90% <10μm; (2) the positive effect of polycarboxylate superplasticizer, that allowed to use water / binder=0.25; (3) formation of finely mixed hydrate phases such as portlandite, ettringite, calcium carboaluminate hydrates and cryptocrystalline calcium hydrosilicates. X-ray powder diffraction quantitative phase analysis of initial HCFA and hydration products in high-strength specimens was performed, which contributes to understanding phase transformations of HCFA during hydration and to improving the properties of the binder

CHANGES OF SKIN AND ORAL MUCOSA IN DIABETES MELLITUS AND THEIR PREVENTION

In article the most often arising diseases from skin are described and a mucosa of an oral cavity at patients with a diabetes mellitus: mechanisms of their emergence, prophylaxis methods

CARDIOVASCULAR SAFETY IN THERAPY OF DIABETES MELLITUS TYPE 2

Diabe tes mellitus is chronical disease, lead to vascular complications. The safety of hypoglycemic therapy influences on cardiovascular complications. In this review results of some large-scale clinic trials directed to prevention of cardiovascular complications are provided