Comparative analysis of stomatological indicators in children and teenagers with arterial hypertension

The frequency of dental diseases among children and teenagers is increasing. The development of diseases is influenced by both local and general factors. The common factors include somatic diseases, in this case that is arterial hypertension. Having examined the children and teenagers with arterial hypertension, we identified the degree of caries and diseases of parodont, evaluated oral health status. We have not revealed changes in the latter. Thefirst expressed manifestations of periodontal tissues diseases were identified in the groups with arterial hypertension. Activity of caries process indicated higher rates in the groups with arterial hypertension. With age, the frequency and intensity of these diseases increase

USE OF MULTIVARIATE DISCRIMINATE ANALYSIS FOR THE PREDICTION OF RISK OF ARTERIAL HYPERTENSION IN ADOLESCENTS

69 adolescents of 14-17 years with essential arterial hypertension (EAH) were examined. The most informative indices of lipid peroxidation and antioxidant defense (LPO - AOD) in the blood of adolescents were studied. The state of LPO - AOD system was assessed by determining diene conjugates, ketodienes and conjugated trienes concentrations, superoxide dismutase activity and total antioxidant activity. A method for prediction of the risk of essential hypertension in adolescents was proposed using multivariate discriminant analysis

Assessment of the system of lipid peroxidation - anti oxidant defense in children with essential arterial hypertension by the methods of spectrophotometry and chemiluminescence

The article presents the results of the research of some indices of lipid peroxidation and antioxidant defense in children of 11-13 years with essential arterial hypertension that were obtained by the methods of spectrophotometry and chemiluminescence. Quantity of products of lipid peroxidation - antioxidant defense in blood serum of patients with essential arterial hypertension significantly exceeds this index in control group. Intensity of the lipid peroxidation processes expressed by the indices of chemiluminescence was higher in patients with essential arterial hypertension than in control group

RESULTS OF THE EXAMINATION OF HYGIENIC STATE OF ORAL CAVITY AND PERIODONTIUM TISSUES IN CHILDREN AND TEENAGERS OF IRKUTSK

At the present moment periodontium tissues diseases are often registered in the population of children and teenagers. The article shows the interrelation of progress of periodontium tissues diseases with hygienic state of oral cavity. In this article we showed thatfirst evident manifestations of periodontium tissues diseases are revealed in thisgroup of patients at the age of eight. Number of diseases increases (up to 13,61 ± 2,48 %] and their severity grows with the increase of years. Th is is related to the h igh level (up to 45,45 %) of unsatisfactory hygienic state of oral cavity of examined children and teenagers

LIPID PEROXIDATION AND ANTIOXIDANT STATUS WITH REPRODUCTIVE DISORDERS

An. analysis the results were obtained in the laboratory of pathophysiology of reproduction, of Scientific Centre of Family Health, and Human Reproduction. Problems, SB RAMS clearly indicate that oxidative stress accompanies and. / or appears like a key pathogenetic link in the development of many types of reproductive disorders. We dedicate, that further researches of the roles of the system, «lipid, peroxidation. — antioxidant protection.» are needed. Moreover, there are good reasons for using of different antioxidants, but it should, be prescribed individually, taking into account of nature of oxidative imbalance

LIPID STATUS IN PERIAND POSTMENOPAUSAL WOMEN WITH INSOMNIA

We present the results of lipid metabolism evaluation in 23 women during perimenopausal and 36 women during postmenopausal period. We also compared lipid profile in depends on present or absence of insomnia in this patients. We found that lipid profile in postmenopausal women does not depend on sleep disorders. But total cholesterol and cholesterol of low density lipoproteins are different in perimenopausal women

The state of lipoperoxidation processes in boys with obesity

The problem of obesity is extremely relevant for modern medical science and healthcare, and child and adolescent obesity deserves special attention. It seems to be interesting to trace the interrelation of pathological processes in obesity in the form of metabolic disorders at the level of the organism and at the cell level - disorders in the system of lipid peroxidation. Studies in adolescent boys are relevant, as there has been a general increase in the incidence in this age category. The purpose of the research was to study the state of the system "lipid peroxidation - antioxidant protection" in adolescent boys with exogenous-constitutional obesity. 19 adolescent boys with obesity were examined in comparison with the control group. Spectrophotometric and fluorometric methods of examination were used. An increase in the level of secondary lipid peroxidation products - ketodienes and conjugated trienes (1.65 times) - was revealed in adolescent boys with obesity. In the antioxidant defense system, differences in this group included reduced values of α-tocopherol (1.42 times), retinol (1.51 times) and superoxide dismutase activity (1.19 times), in the absence of statistically significant changes in the total antioxidant activity (AOA) in blood and components of glutathione status. The revealed disorders allow to recommend the complex therapy including prescription of antioxidants and medicines directed on normalization of lipid exchange at the given category of patients

Peculiarities of the antioxidant status of adolescents with arterial hypertension

One of the most topical problems in the field of healthcare is to solve the issues of an early diagnosis, timely prevention and effective treatment of cardiovascular diseases, which include arterial hypertension (the AH]. Prevalence of EAH in the pediatric population in Russia amounts to 20 %. Despite the fact that the mechanisms of the disease were studied in detail, metabolic changes that led to its early deve^ment in teenagers were still not entirely clear. In the Clinic of FSBSI Scientific Center for Family Health Problems and Human Reproduction (Irkutsk], clinical and functional examination of 48 male adolescents aged 14-17 years, of which 25 patients with stable arterial hypertension and 23 adolescents without somatic pathology with normal blood pressure, was conducted. Antioxidant status was studied in blood plasma and hemolysate. A comparative analysis of the following indicators was conducted: total antioxidant activity, superoxide dismutase activity, level of retinol and α-tocopherol, glutathione system parameters. Patients with stable arterial hypertension were recorded with level of overall antioxidant activity in blood 29 % higher than the benchmark, decreased superoxide dismutase activity by 11 % and content of а-tocopherol by 44 %. Retinol concentration in teenagers with hypertension was two times higher than the content of this indicator in the control group (р = 0.00]. Decrease in the antioxidant levels was found in adolescents with arterial hypertension that can be the cause of the oxidative stress development

Metabolism and Physiological Functions Adjustment of the Organism under Stress Influence

Stress reaction of the organism is a process occurring at the cellular, tissue and systemic levels. The organism responds to any adverse effect with a multi-level reaction, which causes the development of stress and, as a result, adaptation. The damaging effect is due to the excessive strengthening of another adaptive effect – lipotropic, that increases the activity of phospholipases and the intensity of free radical oxidation of lipids through the catecholamines and protein kinases. The changes in the immune system during the adaptation stage are to maintain antigenic homeostasis of the internal environment of the organism due to lymphoid cells, lymphocytes and cytokines. Almost all cells with antigen representation function are capable to produce interleukins under certain conditions. The vascular system is a kind of an indicator of any pathological process, determining the state of regulatory and adaptive mechanisms, the features of the connective tissue matrix. Stress causes a restructuring of metabolism and physiological functions, which increases the organism’s resistance to acute death. Thus, the physiological meaning of the stress reaction is the emergency mobilization of energy and structural resources of the organism and the creation of positive background for the implementation of reactions, aimed at maintaining homeostasis in extreme situations

Ethnic peculiarities of some indicators of metabolic and clinical status in infertile men

The article presents the results of the research of lipid peroxidation (LPO) and activity of components of antioxidant protection (AOP) in men of reproductive age with primary and secondary infertility, living on the territory of Buryatia and have abnormalities in spermogramme. Aim: to study the frequency structure of male infertility, the features of the system lipid peroxidation-antioxidant protection in men with normospermic and pathospermia Buryat and Russian nationality. A retrospective analysis was performed in 562 men of Russian and Buryat nationality, residing in the territory of the Republic of Buryatia. Study groups were as follows: 204 - Buryat, 358 - Russian. In this study we used clinical and laboratory methods and the statistical analysis of the obtained data. Study the contents of products of lipid peroxidation (LPO) and activity of components of the antioxidant protection (AOP) was studied in 113 infertile men (71 Buryat, 42 Russian). Group of infertile men were divided into a group with normospermia and pathospermia. High rate of male factor infertility in men of Russian and Buryat populations was found. No difference was found for frequency and structure of reproductive disorders in men depending on ethnicity. The frequency of male factor in infertile marriages and structure of the causes of male infertility and made comparisons based on ethnicity. Was found the presence of oxidative stress in patients with pathospermia. The findings suggest about the unfavorable pro-and antioxidant status of men with pathospermia, both Russian and Buryat populations. The differences indicate a different degree of activity of metabolic processes in infertile men of different ethnic groups