The development of entrepreneurial capacity and business activity of students of educational establishments using information and communication technologies

The article is devoted to problems of organizational and methodical process modeling of the entrepreneurial potential and business activity of students of educational institutions through the use of Smart-technologies. It is noted that the successful implementation of enterprise and business projects are the basis of economic development of society, with the main factor for the development of entrepreneurship in the country in the long term is to develop the entrepreneurial mindset of young people. Entrepreneurial younger generation reserve created for the period of study, will provide the subsequent decades of business operation, incomenot only to the owner, but also the composition of personnel of the company and, in general, the country. The specifics of perception of the new generation of knowledge, learning and the formation of professional skills is that their effectiveness depends, sometimes completely determined by the degree of use of information and communication technologies, not only in the preparation and implementation of knowledge by the learners, but also in the work themselves teachers. Therefore, an effective and modern instrument for achieving the development goals of the business potential and business students to provide such forms of work with students, which would stimulate their interest in entrepreneurship through the active use of information technologies. The organizational and methodological training model and a set of measures aimed at developing the entrepreneurial potential and business activity of the young generation. To a large extent the elements of our model successfully implemented in REU them. GV Plekhanov at the Faculty of “Marketing Business School and Entrepreneurship”, to carry out training business technologies in relevant areas of knowledge for the information society and the modern state of the economy – business intelligence, innovation and creative business, crisis and risk management, technological Strategic Management (MBA program and a mini-MBA, retraining and refresher courses, professional orientation of varying lengths; trainings and workshops). The main purpose – to form students practical skills and competence for business management in modern conditions. The goal of the entrepreneurial potential and business activity of youth should help to improve the system of vocational guidance work with students, the creation of a continuous training system, the integration of general and further education for the development of entrepreneurship and business activity in the educational institutions of higher and secondary levels of education. A number of recommendations on the organization of professional space ICT teacher and the use of various forms of work with students in order to effectively transfer knowledge, determine their entrepreneurial potential, and the development of entrepreneurial activity. Modern professional space ICT teacher, especially in applications such areas as business training, should be focused on mutual transfer of technologies in an integrated chain: education - science - practice

The distribution of allelic variants in the folate cycle enzyme genes and the level of homocysteine in patients with congenital heart disease and functional single ventricle

The purpose of the investigation was to analyze the distribution of genotypes and allelic variants of the folate cycle enzyme genes in 102 children with congenital heart disease and functional single ventricle and in 89 healthy children. Wild-type MTHFR 677CC was found in 58 (56.9%) children with heart disease, the MTHFR 677CT heterozygous variant was present in 37 (36.3%), the MTHFR 677TT homozygous variant was in 7 (6.9%). Carriage of wild-type MTHFR 1298AA was observed in 45 (44.1%) patients with heart disease; that of the MTHFR 1298AC heterozygous variant was noted in 53 (52.0%) and the MTHFR 1298CC homozygous variant was seen in 4 (3.9%). MTR A27556G gene polymorphism in children with heart disease was distributed as follows: wild-type (AA) in 58 (56.9%) children; the heterozygous (AG) genotype in 40 (39.2%), and the homozygous (GG) genotype in 4 (3.9%). Examination of MTRR A66G gene polymorphism revealed wide-type 66AA in 19 (18.6%) patients, the heterozygous 66AG genotype in 58 (56.9%), and the homozygous 66GG genotype in 12 (24.5%). The genotype distribution did not differ from that in the healthy children. Regardless of the carriage of folate cycle enzyme gene polymorphisms, the plasma homocysteine level tended to increase in the group of patients with congenital heart disease. The mean homocysteine level was significantly higher in the carriers of the MTHFR genotype TT than in the children carrying the genotype CC: 9.0 and 6.3 umol/1, respectively (p=0.02)

A Study of the Genomic Variations Associated with Autistic Spectrum Disorders in a Russian Cohort of Patients Using Whole-Exome Sequencing

This study provides new data on the whole-exome sequencing of a cohort of children with autistic spectrum disorders (ASD) from an underexplored Russian population. Using both a cross-sectional approach involving a control cohort of the same ancestry and an annotation-based approach involving relevant public databases, we explored exonic single nucleotide variants and copy-number variation potentially involved in the manifestation of ASD. The study results reveal new potential ASD candidate-variants found in the studied Russian cohort and show a high prevalence of common ASD-associated genomic variants, especially those in the genes known to be associated with the manifestation of intellectual disabilities. Our screening of an ASD cohort from a previously understudied population allowed us to flag at least a few novel genes (IGLJ2, FAM21A, OR11H12, HIP1, PRAMEF10, and ZNF717) regarding their potential involvement in ASD