Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs

Heterotopic hamster hearts transplanted to unmodified LEW rats underwent humoral rejection in 3 days. Survival was prolonged to a median of 4 days with 2 mg/kg/day FK506. As monotherapy, 15 mg/kg/day cyclophosphamide greatly prolonged graft survival-far more than could be accomplished with RS-61443, brequinar (BQR), mizoribine, methotrexate, or deoxyspergualin. However, when FK506 treatment, which was ineffective alone, was combined with a short induction course (14 or 30 days) of subtherapeutic BQR, RS-61443, or cyclophosphamide, routine survival of heart xenografts was possible for as long as the daily FK506 was continued. In addition, a single large dose of 80 mg/kg cyclophosphamide 10 days preoperatively allowed routine cardiac xenograft survival under FK506. The ability of these antimetabolites to unmask the therapeutic potential of FK506 correlated, although imperfectly, with the prevention of rises of preformed heterospecific cytotoxic antibodies immediately postoperatively. As an adjunct to FK506, azathioprine was of marginal value, whereas mizoribine, methotrexate, and deoxyspergualin (DSPG) were of intermediate efficacy. After orthotopic hepatic xenotransplantation, the perioperative survival of the liver with its well-known resistance to antibodies was less dependent than the heart on the antimetabolite component of the combined drug therapy, but the unsatisfactory results with monotherapy of FK506, BQR, RS-61443, or cyclophosphamide were changed to routine success by combining continuous FK506 with a short course of any of the other drugs. Thus, by breaking down the antibody barrier to xenotransplantation with these so-called antiproliferative drugs, it has been possible with FK506 to transplant heart and liver xenografts with consistent long-term survival of healthy recipients

A Toy Model of Flying Snake's Glide

We have developed a toy model of flying snake's glide [J.J. Socha, Nature vol. 418 (2002) 603.] by modifying a model for a falling paper. We have found that asymmetric oscillation is a key about why snake can glide. Further investigation for snake's glide will provide us details about how it can glide without a wing.Comment: 6 pages, to be submitted to J. Phys. Soc. Jpn. Revised Version submitted to the abov

Weak coupling d-wave BCS superconductivity and unpaired electrons in overdoped La_{2-x}Sr_{x}CuO_{4} single crystals

The low-temperature specific heat (SH) of overdoped La_{2-x}Sr_{x}CuO_{4} single crystals (0.178=<x=<0.290) has been measured. For the superconducting samples (0.178=<x=<0.238), the derived gap values (without any adjusting parameters) approach closely onto the theoretical prediction \Delta_{0}=2.14k_{B}T_{c} for the weak-coupling d-wave BCS superconductivity. In addition, the residual term \gamma(0) of SH at H=0 increases with x dramatically when beyond x~0.22, and finally evolves into the value of a complete normal metallic state at higher doping levels, indicating growing amount of unpaired electrons. We argue that this large \gamma(0) cannot be simply attributed to the pair breaking induced by the impurity scattering, instead the phase separation is possible.Comment: 6 pages, 6 figures; Contents added; Accepted for publication in Phys. Rev.

Broad-band photometric colors and effective temperature calibrations for late-type giants. II. Z<0.02

(Abridged) We investigate the effects of metallicity on the broad-band photometric colors of late-type giants, and make a comparison of synthetic colors with observed photometric properties of late-type giants over a wide range of effective temperatures (T_eff=3500-4800 K) and gravities (log g=0.0-2.5), at [M/H]=-1.0 and -2.0. The influence of metallicity on the synthetic photometric colors is generally small at effective temperatures above \~3800 K, but the effects grow larger at lower T_eff, due to the changing efficiency of molecule formation which reduces molecular opacities at lower [M/H]. To make a detailed comparison of the synthetic and observed photometric colors of late type giants in the T_eff--color and color--color planes, we derive a set of new T_eff--log g--color relations based on synthetic photometric colors, at [M/H]=-0.5, -1.0, -1.5, and -2.0. While differences between the new T_eff--color relations and those available from the literature are typically well within ~100 K, effective temperatures predicted by the scales based on synthetic colors tend to be slightly higher than those resulting from the T_eff--color relations based on observations, with the offsets up to ~100 K. This is clearly seen both at [M/H]=-1.0 and -2.0, especially in the T_eff--(B-V) and T_eff--(V-K) planes. The consistency between T_eff--log g--color scales based on synthetic colors calculated with different stellar atmosphere codes is very good, with typical differences being well within \Delta T_eff~70 K at [M/H]=-1.0 and \Delta T_eff~40 K at [M/H]=-2.0.Comment: 20 pages, 11 figures, A&A accepte

Photometric colors of late-type giants: theory versus observations

To assess the current status in the theoretical modeling of the spectral properties of late-type giants, we provide a comparison of synthetic photometric colors of late-type giants (calculated with PHOENIX, MARCS and ATLAS model atmospheres) with observations, at [M/H]=0.0 and -2.0. Overall, there is a good agreement between observed and synthetic colors, and synthetic colors and published Teff-color relations, both at [M/H]=0.0 and -2.0. Deviations from the observed trends in Teff-color planes are generally within \pm 150K (or less) in the effective temperature range Teff=3500-4800K. Synthetic colors calculated with different stellar atmosphere models typically agree to ~100K, within a large range of effective temperatures and gravities. Some discrepancies are seen in the Teff-(B-V) plane below Teff~3800K at [M/H]=0.0, due to difficulties in reproducing the 'turn-off' to the bluer colors which is seen in the observed data at Teff~3600K. Note that at [M/H]=-2.0 effective temperatures given by the scale of Alonso et al. (1999) are generally lower than those resulting from other Teff-color relations based both on observed and synthetic colors.Comment: 2 pages, 1 figure. Proceedings of the IAU Symposium 232 "The Scientific Requirements for Extremely Large Telescopes", eds. P. Whitelock, B. Leibundgut, and M. Dennefel

Supersymmetric Rotating Black Hole in a Compactified Spacetime

We construct a supersymmetric rotating black hole with asymptotically flat four-dimensional spacetime times a circle, by superposing an infinite number of BMPV black hole solutions at the same distance in one direction. The near horizon structure is the same as that of the five-dimensional BMPV black hole. The rotation of this black hole can exceed the Kerr bound in general relativity ($q\equiv a/G_4 M=1$), if the size is small.Comment: 7 pages, 3 figures; v2: comparison with black ring removed, detailed discussion of rotation added, refs. added, v3: minor corrections, version to appear in PR

AGB Stars as Tracers of Star Formation Histories: Implications for GAIA Photometry and Spectroscopy

We argue that tracing star formation histories with ESA's space mission GAIA using main sequence turn-off (MSTO) point dating will mainly be effective in cases of mild interstellar extinction (E(B-V)<0.5). For higher reddenings the MSTO approach will be severely limited both in terms of traceable ages (t<0.5 Gyr at 8 kpc; E(B-V)=1.0) and/or distances (d<2 kpc for t=15 Gyr; E(B-V)=1.0), since the MSTO will be located at magnitudes too faint for GAIA. AGB stars may alternatively provide precise population ages with GAIA for a wide range of ages and metallicities, with traceable distances of up to 250 kpc at E(B-V)=0 (d=15 kpc if E(B-V)=2.0). It is essential however that effective temperatures precise to 0.01 dex, metallicities to 0.2 dex, and E(B-V) to 0.03 are derived for individual stars, in order to obtain their ages precise to 0.2 dex. This task is quite challenging for GAIA photometry and spectroscopy, though preliminary tests show that comparable precisions may be achieved with GAIA medium band photometry.Comment: Proceedings of the Monte Rosa Conference "GAIA spectroscopy, science and technology" Gressoney Saint Jean (Valle d'Aosta, Italy), Sept 9-12, 2002, ed. U. Munari, ASP Conf. Ser., in pres

Change of the Ground State upon Hole Doping Unveiled by Ni Impurity in High-TcT_{\rm c} Cuprates

The electronic ground state in high-$T_{\rm c}$ cuprates where the superconducting state is suppressed by Ni substitution has been investigated in La$_{2-x}$Sr$_x$Cu$_{1-y}$Ni$_y$O$_4$ from the specific heat and muon spin relaxation measurements. It has been found that the ground state changes from a magnetically ordered state with the strong hole-trapping by Ni to a metallic state with the Kondo effect of Ni with increasing hole-concentration. Moreover, the analysis of the results has revealed that a phase separation into the magnetically ordered phase and the metallic phase occurs around the boundary of two phases.Comment: 11pages, 4 figure