Dentists’ Leadership‐Related Educational Experiences, Attitudes, and Past and Current Behavior

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153576/1/jddj002203372014786tb05741x.pd

Oral health‐related concerns, behavior, and communication with health care providers of patients with breast cancer: impact of different treatments

AimThe objectives are to compare responses of breast cancer (BCa) treatment groups (chemotherapy, tamoxifen, and aromatase inhibitors (AIs) to each other and a control regarding (a) subjective oral health, (b) oral health‐related behaviors, (c) oral health‐related concerns, and (d) communication with health care providers.MethodsSurvey data were collected from 140 postmenopausal BCa patients and 41 healthy postmenopausal control respondents.ResultsBCa patients reported on average more frequent mouth sores/mucositis (5‐point scale with 1 = never: 1.63 vs. 1.14; p < .01), glossadynia (1.60 vs. 1.07; p < .01), xerostomia (2.48 vs. 1.40; p < .01), and dysgeusia (2.10 vs. 1.46; p < .01) than the control respondents. Patients undergoing chemotherapy were more aware that cancer treatment can affect their oral health than patients on tamoxifen/AI (93% vs. 55%/56%; p < .001). BCa patients reported being more frequently informed by oncologists about oral health‐related effects of cancer treatment than by dentists. Oncologists/nurses were more likely to communicate about oral health‐related treatment effects with patients undergoing chemotherapy than patients on tamoxifen or AIs. Few BCa patients perceived dentists as knowledgeable about cancer treatment‐related oral concerns and trusted them less than oncologists.ConclusionsBCa treatments impact oral health. Low percentages of BCa patients had received specific information about impacts of BCa treatments on oral health from their dentists.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141444/1/scd12266.pd

Periodontal health, perceived oral health, and dental care utilization of breast cancer survivors

ObjectivesThis population‐based analysis examined the prevalence of periodontal diseases along with the self‐perceived oral health and patterns of dental care utilization of breast cancer survivors in the United States.MethodsData from the 1999‐2004 National Health and Nutrition Surveys were utilized, examining information from 3,354 women between 50 and 85 years of age. Primary outcomes were gingivitis and periodontitis, self‐perceived oral health, and dental care utilization. Logistic regression analyses were used to estimate relationships of breast cancer diagnosis and primary outcomes while controlling for confounding factors.ResultsBreast cancer survivors were more likely to be older than 55 years, white, nonsmokers, have higher levels of education and income, and a higher prevalence of osteoporosis. Breast cancer survivors were significantly less likely to have dental insurance (P = 0.04). Utilization of dental services and reason for last dental visit did not significantly differ between groups. A history of a breast cancer diagnosis did not increase the odds of gingivitis [odds ratio (OR):  1.32; 95 percent confidence interval (CI): 0.53‐3.63], periodontitis (OR: 1.82; 95 percent CI:  0.89‐4.01), or poor self‐perceived oral health (OR: 0.89; 95 percent CI: 0.61‐1.33) after adjusting for age, race, education, dental care utilization, and smoking status.ConclusionsIn this sample, a history of breast cancer does not significantly impact periodontal health, self‐perceived oral health, and dental care utilization. However, efforts should be made to assure that breast cancer survivors have dental insurance.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111973/1/jphd12084.pd

Effect of Faculty Development Activities on Dental Hygiene Faculty Perceptions of and Teaching About Motivational Interviewing: A Pilot Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153716/1/jddjde017048.pd

Human Very Small Embryonic-Like Cells Generate Skeletal Structures, In Vivo

Human very small embryonic-like (hVSEL) cells are a resident population of multipotent stem cells in the bone marrow involved in the turnover and regeneration of tissues. The levels of VSEL cells in blood are greatly increased in response to injury, and they have been shown to repair injured tissues. Adult hVSEL cells, SSEA-4+/CD133+/CXCR4+/Lin?/CD45?, express the pluripotency markers (Oct-4 and Nanog) and may be able to differentiate into cells from all 3 germ lineages. hVSEL cells isolated from blood by apheresis following granulocyte?colony-stimulating factor mobilization were fractionated and enriched by elutriation and fluorescence activated cell sorting. Collagen sponge scaffolds containing 2,000?30,000 hVSEL cells were implanted into cranial defects generated in SCID mice. Analysis by microcomputed tomography showed that a cell population containing VSEL cells produced mineralized tissue within the cranial defects compared with controls at 3 months. Histologic studies showed significant bone formation and cellular organization within the defects compared with cellular or scaffold controls alone. Antibodies to human leukocyte antigens demonstrated that the newly generated tissues were of human origin. Moreover, human osteocalcin was identified circulating in the peripheral blood. There was evidence that some level of hVSEL cells migrated away from the defect site, using quantitative real-time polymerase chain reaction to detect for human-specific Alu sequences. This study demonstrates that hVSEL cells are able to generate human bone tissue in a mouse model of skeletal repair. These studies lay the foundation for future cell-based regenerative therapies for osseous and connective tissue disorders, including trauma and degenerative conditions, such as osteoporosis, fracture repair, and neoplastic repair.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140198/1/scd.2012.0327.pd

Depot Medroxyprogesterone Acetate Use and Periodontal Health in 15‐ to 44‐Year‐Old US Females

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141038/1/jper1008.pd

Oral Contraceptives and Periodontal Diseases: Rethinking the Association Based Upon Analysis of National Health and Nutrition Examination Survey Data

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141450/1/jper1374.pd

Stromal‐Derived Factor‐1α (CXCL12) Levels Increase in Periodontal Disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142300/1/jper0845.pd

Periodontal health in breast cancer patients on aromatase inhibitors versus postmenopausal controls: a longitudinal analysis

AimThis study was conducted to determine periodontal changes in postmenopausal breast cancer (BCa) survivors using aromatase inhibitors (AI) as compared to postmenopausal women without BCa.MethodsAn 18‐month prospective examination of periodontal health in postmenopausal women (29 receiving AI therapy; 29 women without BCa) was conducted at University of Michigan. Comprehensive periodontal examinations including alveolar bone height (ABH) were conducted at baseline, 6, 12, and 18 months. Bisphosphonate, vitamin D, and calcium supplementation were collected via chart review. Linear mixed models were utilized to investigate the relationship between AI and periodontal measures.ResultsAromatase inhibitor users had significantly deeper probing depths, more dental plaque and clinical attachment loss as compared to controls at the 6, 12, and 18 month study visits (p < 0.05). ABH loss was seen over time within the AI group. The linear mixed model showed a significant effect of time as well as an interaction between aromatase inhibitor use and calcium supplement status. AI users taking calcium experienced less ABH loss over the study than AI users not taking calcium (p = 0.005).ConclusionAromatase inhibitor therapy has a negative impact on the periodontal health of postmenopausal BCa patients. Calcium supplementation appears to mitigate ABH loss in women on AI.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/133559/1/jcpe12562_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133559/2/jcpe12562.pd

Periodontal Health in Women With Early‐Stage Postmenopausal Breast Cancer Newly on Aromatase Inhibitors: A Pilot Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141857/1/jper0906.pd