6,491 research outputs found
Case report. A rare case of giant basal cell carcinoma and malignant melanoma
The presence of two several skin lesions in the same patient is a rare occurrence in dermatological findings. The associations of malignant melanoma (MM) and giant basal cell carcinoma (BCC) within the same patient have only been described in few cases in the literature.1,6 Is there a common genetic origin? However, until now the pathogenesis of collision tumors existing of MM and BCC remains unclear. We, therefore, report a case of association of MM and BCC in the same patient
A rare case of leiomyoma of the bladder
Bladder leiomyoma is a benign tumour of the bladder and constitute <0.5% of all bladder tumors. We report a clinical case of a 51‑year‑old female who presented with with symptomatic bladder leiomyoma. An ultrasound examination showed well-defined bladder leiomyoma in the right posterior bladder wall, which was excised through a transurethral resection. The pathologic diagnosis was bladder leiomyoma
Big Data in Critical Infrastructures Security Monitoring: Challenges and Opportunities
Critical Infrastructures (CIs), such as smart power grids, transport systems,
and financial infrastructures, are more and more vulnerable to cyber threats,
due to the adoption of commodity computing facilities. Despite the use of
several monitoring tools, recent attacks have proven that current defensive
mechanisms for CIs are not effective enough against most advanced threats. In
this paper we explore the idea of a framework leveraging multiple data sources
to improve protection capabilities of CIs. Challenges and opportunities are
discussed along three main research directions: i) use of distinct and
heterogeneous data sources, ii) monitoring with adaptive granularity, and iii)
attack modeling and runtime combination of multiple data analysis techniques.Comment: EDCC-2014, BIG4CIP-201
Evaluating the expression of urokinase and tissue leukocyte being in benign and malignant breast disease
Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of
the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis.
Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with
benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is
significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast,
malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in
the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers
show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients
express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA
was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis.
The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors,
progesterone and HER2 (state of triple negative), in which the expression of uPA is very high.
Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the
one expressed by malignant nodular uPA.Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of
the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis.
Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with
benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is
significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast,
malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in
the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers
show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients
express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA
was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis.
The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors,
progesterone and HER2 (state of triple negative), in which the expression of uPA is very high.
Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the
one expressed by malignant nodular uPA
A case of primary Hodgkin's lymphoma of the parotid gland. Case report and differentian diagnosis from Kuttner's Syndrom
Abstract
We report a rare case of primary Hodgkin’s lymphoma (HL) of the submandibular
gland, with initially diagnosis of Kuttner’s Syndrom. A 48 years old man was referred to our hospital foe evaluation
of a submandibular mass. Although the initial Fine Needle Aspiration and subsequent cytology was highly suggestive for a cronic sialadenitis with lymphoid cells.
After surgical gland removal we obtained a definitive diagnosis of Hodgkin’s lymphoma in
submandibular gland a seat where the most common lymphoma tipe is B
Which is the most accurate diagnostic procedure in Tamoxifen treated breast cancer patients
Purpose: The aim of this study was to evaluate the diagnostic accuracy of bi-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound (TVUS), hysterosonography (HSSG) and hysteroscopy in the detection of endometrial pathology in women treated with tamoxifen (TMX) for breast cancer.
Methods: Forty-two patients, affected by breast cancer under treatment with TMX, underwent 2D-3D TVUS, HSSG and hysteroscopy completed by biopsy, after abnormal findings following a routine 2D TVUS examination.
Results: 3D-TVUS was more accurate than 2D-TVUS in the detection of atrophic endometrium confirmed by biopsy and in the detection of endometrial polyps.
HSSG and hysteroscopy detected atrophic endometrium and endometrial polyps significantly better than ultrasound scan. Endometrial carcinoma was detected in two cases, and in both HSSG and hysteroscopy were 100% diagnostic.
Conclusion: In TMX treated breast cancer patients, HSSG and hysteroscopy provide more accurate diagnosis than 2D-3D ultrasound in the detection of treatment related endometrial lesions
Open and / or laparoscopic surgical treatment of liver hydatic cysts
Hydatid disease is a severe parasitic disease with a widely ranging distribution. In the human being the liver is the most frequent organ affected. 1 The treatment should be individualized to the morphology, size, number and location of the cysts, that is why a variety of surgical operations have been advocated from complete resection like total pericystectomy or partial hepatectomy to laparoscopy to a minimally invasive procedures like percutaneous aspiration of cysts to conservative drug therapy. 3-4 This study compares laparoscopic versus open management of the hydatid cyst of liver the surgical approach to liver echinococcosis is still a controversial issue and shows our results of surgical treatment of liver hydatid cysts during a 3-years period
A study of gas contaminants and interaction with materials in RPC closed loop systems
Resistive Plate Counters (RPC) detectors at the Large Hadron Collider (LHC)
experiments use gas recirculation systems to cope with large gas mixture
volumes and costs. In this paper a long-term systematic study about gas
purifiers, gas contaminants and detector performance is discussed. The study
aims at measuring the lifetime of purifiers with unused and used cartridge
material along with contaminants release in the gas system. During the
data-taking the response of several RPC double-gap detectors was monitored in
order to characterize the correlation between dark currents, filter status and
gas contaminants
Metabolically healthy obesity (Mho) vs. metabolically unhealthy obesity (muo) phenotypes in pcos: Association with endocrine-metabolic profile, adherence to the mediterranean diet, and body composition
Obesity and obesity-related low-grade inflammation are common findings in polycystic ovary syndrome (PCOS), the most common endocrine-metabolic disorder-affecting women in reproductive age. The terms metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) have been introduced to define individuals with obesity in whom cardio-metabolic risk factors are absent or present, respectively. To date, evidence investigating differences in body composition and adherence to the Mediterranean diet (MD) between MHO and MUO-PCOS women are lacking. Aim of this study was to better characterize the determinants of the metabolic health status in PCOS patients with obesity according to MHO and MUO phenotypes by evaluating endocrine-metabolic profile, inflammatory status, adherence to the MD, and body composition. The study population consisted of 94 treatment-naïve women with PCOS and obesity (BMI = 38.23 ± 6.62 kg/m2 and age = 24.12 ± 3.68 years). Compared PCOS MHO with PCOS MUO patients, the latter had higher levels of high-sensitivity C-reactive protein (hs-CRP) (p < 0.001), testosterone (p < 0.001), and insulin (p < 0.001), worse metabolic parameters, and higher Homeostatic Model Assessment of Insulin Resistance (HoMA-IR), Visceral Adiposity Index (VAI), and Fatty liver Index (FLI) (p < 0.001). Furthermore, PCOS MUO patients had lower adherence to the MD (p < 0.001) in spite of the same total energy intake (p = 0.102) as compared to PCOS MHO. The presence of MUO was associated with highest hs-CRP levels (OR = 1.49, p < 0.001), more severe hyperandrogenism and cardio-metabolic indices (p < 0.001). On the contrary, being PCOS MUO was associated with lower adherence to the MD (OR = 0.28, p < 0.001), and smaller PhAs (OR = 0.04, p < 0.001). Using a regression linear analysis model PREDIMED score entered at the first step (p < 0.001), followed by VAI (p < 0.001), and FLI (p = 0.032) in this analysis. At ROC analysis, a PREDIMED score of ≤4 (p < 0.001, AUC 0.926) could serve as a threshold for a significantly increased risk of presence the MUO-PCOS phenotype. To the best of our knowledge, this is the first study that characterized MHO and MUO-PCOS women on the basis of their adherence to the MD, body composition, and cardio-metabolic indices, providing evidence of the usefulness of adjunctive diagnostic parameters to better differentiate the MHO/MHO phenotypes in this cohort of PCOS patients with obesity
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