Ferro-electric phase transition in a polar liquid and the nature of \lambda-transition in supercooled water

We develop a series of approximations to calculate free energy of a polar liquid. We show that long range nature of dipole interactions between the molecules leads to para-electric state instability at low temperatures and to a second-order phase transition. We establish the transition temperature, T_{c}, both within mean field and ring diagrams approximation and show that the ferro-electric transition may play an important role explaining a number of peculiar properties of supercooled water, such as weak singularity of dielectric constant as well as to a large extent anomalous density behavior. Finally we discuss the role of fluctuations, shorter range forces and establish connections with phenomenological models of polar liquids.Comment: 5 pages, 1 eps figure, density anomaly at T=4C analysis adde

Didactic principles of university information educational systems designing

© Authors. The attention of all parts of perspective education system should be focused on promising information technologies - a catalyst for development. Presenting information as a new resource for society development, the authors determine the didactic basis for designing effective information educational systems. Universal didactic principles for information educational systems design have been developed, the details of which for discipline and for the subject adapt them to the university organizational and pedagogical conditions. The pedagogical management functions in modern educational conditions that determine the students' motivation and stimulation initiation mechanism for mastering a knowledge new system to develop the individual's creative abilities, self-development are revealed. The paper is intended for researchers, teachers, and specialists in the field of information educational technologies

Интерстициальное заболевание легких, ассоциированное с системной склеродермией, у пациента с длительным стажем работы мраморщиком

Systemic sclerosis (SSc) is a disease characterized by vasculopathy, fibrosis of the skin and internal organs, most often complicated by interstitial lung disease (ILD). The incidence of SSc reaches 20 cases per 1 million population per year, while changes in the lungs are found in more than half of patients and are characterized by a rapid increase in fibrosis, poorly controlled respiratory failure, and an unfavorable prognosis. It is important to trace the features of the formation and course of ILD and its relationship with occupational hazards in patients diagnosed with SSc. Dust pathology of the respiratory organs (chronic dust bronchitis and silicosis) is most typical for people with long work experience in mining. Silicosis in these patients may be accompanied by SSc with rapid progression of bronchial obstruction, restrictive disorders, as well as myocardial involvement and the development of pulmonary hypertension.Системная склеродермия (ССД) – заболевание, характеризующееся васкулопатией, фиброзом кожи и внутренних органов и наиболее часто осложняющееся интерстициальным заболеванием легких (ИЗЛ). Заболеваемость ССД достигает 20 случаев на 1 млн населения в год, при этом изменения в легких обнаруживаются более чем у половины пациентов и отличаются быстротой нарастания фиброза, плохо контролируемой дыхательной недостаточностью и неблагоприятным прогнозом. Важно проследить особенности формирования и течения ИЗЛ и его связь с профессиональными вредностями у пациентов с диагнозом ССД. Пылевая патология органов дыхания (хронический пылевой бронхит и силикоз) наиболее характерны для людей с длительным стажем работы в отраслях горной промышленности. Силикоз у таких пациентов может сопровождаться ССД с быстрым прогрессированием бронхиальной обструкции, рестриктивных нарушений, а также поражением миокарда и развитием легочной гипертензии

Localisation of Human Papillomavirus 16 E7 Oncoprotein Changes with Cell Confluence

E7 is one of the best studied proteins of human papillomavirus type 16, largely because of its oncogenic potential linked to cervical cancer. Yet the sub-cellular location of E7 remains confounding, even though it has been shown to be able to shuttle between the nucleus and the cytoplasm. Here we show with immunocytochemistry that E7 proteins are located in the nucleus and cytoplasm in sub-confluent cells, but becomes cytoplasmic in confluent cells. The change in E7's location is independent of time in culture, cell division, cell cycle phase or cellular differentiation. Levels of E7 are also increased in confluent cells as determined by Western blotting. Our investigations have also uncovered how different analytical techniques influence the observation of where E7 is localised, highlighting the importance of technical choice in such analysis. Understanding the localisation of E7 will help us to better comprehend the function of E7 on its target proteins

Didactic principles of university information educational systems designing

© Authors. The attention of all parts of perspective education system should be focused on promising information technologies - a catalyst for development. Presenting information as a new resource for society development, the authors determine the didactic basis for designing effective information educational systems. Universal didactic principles for information educational systems design have been developed, the details of which for discipline and for the subject adapt them to the university organizational and pedagogical conditions. The pedagogical management functions in modern educational conditions that determine the students' motivation and stimulation initiation mechanism for mastering a knowledge new system to develop the individual's creative abilities, self-development are revealed. The paper is intended for researchers, teachers, and specialists in the field of information educational technologies