Globular cluster population of the HST frontier fields galaxy J07173724+3744224

We present the first measurement of the globular cluster population surrounding the elliptical galaxy J07173724+3744224 (z=0.1546). This galaxy is located in the foreground in the field-of-view of the Hubble Space Telescope (HST) Frontier Fields observations of galaxy cluster MACS J0717.5+3745 (z=0.5458). Based on deep HST ACS F435W, F606W, and F814W images, we find a total globular cluster population of N_tot = 3441 +/- 1416. Applying the appropriate extinction correction and filter transformation from ACS F814W to the Johnson V-band, we determine that the host galaxy has an absolute magnitude of M_V = -22.2. The specific frequency was found to be S_N = 4.5 +/- 1.8. The radial profile of the globular cluster system was best fit using a powerlaw of the form $\sigma\sim R^{-0.6}$, with the globular cluster population found to be more extended than the halo light of the host galaxy ($\sigma_{halo}\sim R^{-1.7}$). The F435W-F814W colour distribution suggests a bimodal population, with red globular clusters 1-3x more abundant than blue clusters. These results are consistent with the host elliptical galaxy J07173724+3744224 having formed its red metal-rich GCs in situ, with the blue metal-poor globular clusters accreted from low-mass galaxies.Comment: 21 pages, 14 figures, 2 tables, revised following peer-review, accepted for publication in MNRA

The t->WZb decay in the Standard Model: A Critical Reanalysis

We compute the t->WZb decay rate, in the Standard Model, at the leading order in perturbation theory, with special attention to the effects of the finite widths of the W and Z bosons. These effects are extremely important, since the t->WZb decay occurs near its kinematical threshold. They increase the value of the decay rate by orders of magnitude near threshold or allow it below the nominal threshold. We discuss a procedure to take into account the finite-width effects and compare the results with previous studies of this decay. Within the Standard Model, for a top quark mass in the range between 170 and 180 GeV, we find BR(t->WZb) ~ 2 x 10^{-6}, which makes the observation at the LHC very difficult if at all possible.Comment: 10 pages, 4 eps figures, LaTeX. Few references added and minor changes in the text. Results unchanged. Final version to appear on PL

Radiolysis of the Glycolaldehyde-Na+Montmor- illonite and Glycolaldehyde-Fe3+Montmorillonite Systems in Aqueous Suspension under Gamma Radiation Fields: Implications in Chemical Evolution

The stability and reactivity of organic molecules with biological and pre-biological significance in primitive conditions are of paramount importance in chemical evolution studies. Sugars are an essential component in biological systems for the different roles that they play in living beings. The objective of the present work is to study the gamma radiolysis of aqueous solutions of glycolaldehyde, the simplest sugar and aqueous suspensions of glycolaldehyde-Na+-montmorillonite and glycolaldehyde-Fe3+Montmorillonite. Our results indicate that the radiolysis of the aqueous solutions of glycolaldehyde (0.03M), oxygen free, mainly produce the linear dimer known as eritriol (122 g/mol) and a sugar-like compound with six carbon atoms (180 g/mol). The experiments with the clay suspensions show that clays can adsorb glycolaldehyde and protect it from gamma irradiation. Additionally, it was observed that depending on the cation present in the clay, the percentage and the product (monomer or cyclic dimer) adsorption was different. In the case of Fe3+ Montmorillonite, this clay catalyzed the decomposition of glycolaldehyde, forming small amounts non-identified products. The analysis of these systems was performed by ATR-FTIR, UV spectroscopy, liquid chromatography (UHPLC-UV), and HPLC coupled to a mass spectrometry

Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures

Several neuropsychiatric and neurodegenerative disorders are characterised by motivational impairments manifested as lack of behavioural activation or energy resulting in significant functional impairment. Given the clinical significance of these symptoms, the study of motivation in preclinical research has recently intensified. This review briefly summarises the tasks that have been implemented for the evaluation of motivation in different species, emphasising the recent use of touchscreen-based rodent testing systems. This methodology has been widely used in the evaluation of multiple cognitive domains emphasising their translational value and flexibility. Recently touchscreen-based versions of classical tasks for the evaluation of motivation have been or are currently being developed and validated, thus facilitating translation from animal to human research and promoting their implementation in clinical contexts

Impact of Caffeine on Ethanol-Induced Stimulation and Sensitization: Changes in ERK and DARPP-32 Phosphorylation in Nucleus Accumbens

Background: Caffeine is frequently consumed with ethanol to reduce the impairing effects induced by ethanol, including psychomotor slowing or incoordination. Both drugs modulate dopamine (DA)-related markers in accumbens (Acb), and Acb DA is involved in voluntary locomotion and locomotor sensitization. The present study determined whether caffeine can affect locomotion induced by acute and repeated ethanol administration in adult male CD-1 mice. Methods: Acute administration of caffeine (7.5 to 30.0 mg/kg) was evaluated for its effects on acute ethanol-induced (1.5 to 3.5 g/kg) changes in open-field horizontal locomotion, supported rearing, and rearing not supported by the wall. DA receptor-dependent phosphorylation markers were assessed: extracellular signal-regulated kinase (pERK), and dopamine-and cAMP-regulated phosphoprotein Mr32kDa phosphorylated at threonine 75 site (pDARPP-32-Thr75) in Acb core and shell. Acutely administered caffeine was also evaluated in ethanol-sensitized (1.5 g/kg) mice. Results: Acute ethanol decreased both types of rearing. Caffeine increased supported rearing but did not block ethanol -induced decreases in rearing. Both substances increased horizontal locomotion in a biphasic manner, and caffeine potentiated ethanol-induced locomotion. Although ethanol administered repeatedly induced sensitization of locomotion and unsupported rearing, acute administration of caffeine to ethanol-sensitized mice in an ethanol-free state resulted in blunted stimulant effects compared with those seen in ethanol-naïve mice. Ethanol increased pERK immunoreactivity in both subregions of the Acb, but coadministration with caffeine blunted this increase. There were no effects on pDARPP-32(Thr75) immunoreactivity. Conclusions: The present results demonstrated that, after the first administration, caffeine potentiated the stimulating actions of ethanol, but did not counteract its suppressant or ataxic effects. Moreover, our results show that caffeine has less activating effects in ethanol-sensitized animals