Cardiovascular magnetic resonance findings in a case of Danon disease

Danon disease is a rare X-linked dominant lysosomal glycogen storage disease that can lead to severe ventricular hypertrophy and heart failure. We report a case of Danon disease with cardiac involvement evaluated with cardiovascular magnetic resonance, including late gadolinium enhancement and perfusion studies

Influence of time on the image quality in nuclear medicine imaging using 67Ga citrate

Diagnostyka chłoniaków z użyciem 67Ga jest powszechnie przyjętym postępowaniem, jednakże ze względu na długi efektywny okres rozpadu tego izotopu konieczne jest ustalenie optymalnego czasu badania. W pracy poddano ocenie 70 zmian widocznych w badaniach całego ciała (whole body) oraz 74 w badaniach określonego odcinka (hot spots). Badanie polegało na ocenie jakościowej i ilościowej zmian chorobowych. W badaniu stwierdzono, że najlepsze obrazy - zarówno w badaniu całego ciała, jak i określonego odcinka ciała - otrzymywano w badaniach po 7 dobach, a najgorsze po 10. Badanie scyntygraficzne z zastosowaniem 67Ga należy przeprowadzać w 7 dobie po podaniu znacznika.Using 67Ga in diagnostic of lymphomas is common. In view of long effective half-life time of the isotope it is necessary to find optimal time of examination. In the study 70 regions of interest in the whole body scans and 74 in hot spot areas were examined. The aim of the study was to evaluate quality and quantity of findings. It was found that the best images were obtained in both - whole body and hot spot scans after 7 days, and the worst after 10 days. Examination using 67Ga should be made 7 days after the injection

Invisible Base Electrode Coordinates Approximation for Simultaneous SPECT and EEG Data Visualization

This work was performed as part of a larger research concerning the feasibility of improving the localization of epileptic foci, as compared to the standard SPECT examination, by applying the technique of EEG mapping. The presented study extends our previous work on the development of a method for superposition of SPECT images and EEG 3D maps when these two examinations are performed simultaneously. Due to the lack of anatomical data in SPECT images it is a much more difficult task than in the case of MRI/EEG study where electrodes are visible in morphological images. Using the appropriate dose of radioisotope we mark five base electrodes to make them visible in the SPECT image and then approximate the coordinates of the remaining electrodes using properties of the 10-20 electrode placement system and the proposed nine-ellipses model. This allows computing a sequence of 3D EEG maps spanning on all electrodes. It happens, however, that not all five base electrodes can be reliably identified in SPECT data. The aim of the current study was to develop a method for determining the coordinates of base electrode(s) missing in the SPECT image. The algorithm for coordinates approximation has been developed and was tested on data collected for three subjects with all visible electrodes. To increase the accuracy of the approximation we used head surface models. Freely available model from Oostenveld research based on data from SPM package and our own model based on data from our EEG/SPECT studies were used. For data collected in four cases with one electrode not visible we compared the invisible base electrode coordinates approximation for Oostenveld and our models. The results vary depending on the missing electrode placement, but application of the realistic head model significantly increases the accuracy of the approximation

A prospective study of posttraumatic epilepsy

Clinical, EEG and neuroimaging data obtained from 4 serial assessments from the acute phase to one year later in 104 head injured adult patients were used for a prospective study of risk factors for post-traumatic epilepsy. Severe or moderate head injuries (HI) were prevalent among the entire group (68.3%) in which early seizures (ES) occurred in 9.4% and late seizures (LS) in 17.3%. Crises were considered LS when they occurred after 4 weeks from HI. Coma duration, ES: temporal lobe lesions shown by CT in the acute traumatic phase and focal gliosis with or without haemosiderin shown by MRI one year later were significantly prevalent in patients with LS who also developed an early slow wave or epileptiform EEG focus in significantly higher percentages than patients without LS. Moreover, the EEG focus preceded the first late seizure with a mean time interval of one month