DIABETES MELLITUS IN PATIENTS FROM BURYAT POPULATION

The paper considers specific features of type 1 Diabetes Mellitus in patients from Buryat populations. Characteristics of the incidence and prevalence of type 1 Diabetes Mellitus in patients of Buryat nationality are presented. Clinicalfeatures of type 1 Diabetes Mellitus in patients-buryats are highlighted. The aim of this study was to determine the ethnic characteristics of Diabetes Mellitus in patientsfrom Buryat population. It was found that the incidence and prevalence of type 1 Diabetes Mellitus in the Buryat population was below the relevant indicators of Russia and constituted 0.73 and 24.18 per 100 thousand population. Late vascular complications of the disease (diabetic nephropathy, diabetic retinopathy) occur in patients with type 1 Diabetes Mellitus of Buryat nationality less frequently than in the general population of patients with type 1 Diabetes Mellitus. Found that diabetic polyneuropathy (DP) was diagnosed in 25.8 % of patients

ACTIVITY OF AMINOLEVULINATE SYNTHASE OF BONE MARROW AND LIVER OF NEWBORN AUGUST AND WISTAR RATS AFTER ACUTE POSTNATAL HYPOXIA

Newborn Wistar and August rats (20 rats in each experimental group) were exposed to acute postnatal hypoxic hypoxia (by the mixture of 95% nitrogen and 5% oxygen). Determination of activity of aminolevulinate synthase (ALA-synthase) in bone marrow and liver were in control group, and on the 1st and 3rd days of life (in liver - only on the 3rd day). Infant rats of various lines differed by the response of an organism to hypoxic exposure that confirms its genetic predetermination. Activities of ALA-synthase in bone marrow and liver were reciprocal both in normal development and after hypoxia.

Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)

This review presents data on changes in the physiology of sleep during reproductive aging. It is noted that insomnia and obstructive sleep apnea syndrome (OSAS) are the main sleep disorders. The results of foreign and domestic studies in the field of free radical oxidation during sleep deprivation in animal models are presented, indicating the dependence of processes on the duration of sleep deprivation. The largest number of studies of free radical processes in a person with somnological pathology was carried out in the study of OSAS. Blood, urine, saliva, condensate of exhaled air can be biomaterial for determining the parameters of free radical oxidation. It was shown that the intensity of oxidative stress depends on the severity of OSAS, as evidenced by the positive correlation of the level of active products of thiobarbituric acid, the products of oxidation of proteins and carbonyl groups with the apnea/hypopnea index, determining the development of not only oxidative, but also carbonyl stress in patients with a severe degree OSAS. Biomarkers such as thioredoxin, malondialdehyde, superoxide dismutase, and reduced iron have shown a more stable relationship between increased oxidative stress and OSA. Despite the results obtained, the question of the association of oxidative stress and hypoxia in OSA remains debatable, which is associated with the opposite results of some studies. Insomnia, which occurs mainly in females, is accompanied by a high level of end products of lipid peroxidation with a decrease in the activity of antioxidants such as paraoxonase, an enzymatic component of the glutathione system. Along with this, menopausal women present low levels of uric acid, which correlates with high scores of the Pittsburgh sleep quality index questionnaire. Recent studies have identified an association between the activity of the «lipoperoxidation – antioxidants» system and the Clock 3111T/C gene polymorphism in menopausal Caucasian women, indicating the protective role of the minor allele

INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN

The aim of the review is to analyze literature data about sleep homeostasis and the role of the one of circadian system key elements – melatonin – in the regulation of the sleep-wake cycle in women in menopause. It was shown that the prevalence and structure of sleep disorders depends on the menopausal phase. It was revealed that the melatonin content in the body, determined in various biological media (blood, saliva, urine), depends on age, sex, race, and chronotype. It was shown that morning melatonin can be used as a biological marker for determining the chronotype. Most studies indicated a decrease in melatonin level with aging. Moreover, women have lower melatonin level than men. In case of insomnia, lower melatonin level was found, although the results of the studies are ambiguous. The shift in the peak of hormone secretion in the early morning hours was described in menopausal women. Also, the dependence of melatonin circadian rhythm on the menopausal phase was revealed, which determines different approaches to insomnia therapy. We revealed the association of melatonin secretion circadian rhythms with Clock 3111T/C gene polymorphism in Caucasian patients with insomnia, which allows considering 3111T allele as risky in the formation of melatonin circadian rhythm disturbances in these patients

THE STATE OF ANTIOXIDANT SYSTEM OF THE WOMEN UNDERGOING THE PROCEDURE OF IN VITRO FERTILIZATION

The antioxidant system activity was studied in 74 patients undergoing infertility treatment by the vitro fertilization, depending on the effectiveness of the procedure

RESULTS OF THE EXAMINATION OF HYGIENIC STATE OF ORAL CAVITY AND PERIODONTIUM TISSUES IN CHILDREN AND TEENAGERS OF IRKUTSK

At the present moment periodontium tissues diseases are often registered in the population of children and teenagers. The article shows the interrelation of progress of periodontium tissues diseases with hygienic state of oral cavity. In this article we showed thatfirst evident manifestations of periodontium tissues diseases are revealed in thisgroup of patients at the age of eight. Number of diseases increases (up to 13,61 ± 2,48 %] and their severity grows with the increase of years. Th is is related to the h igh level (up to 45,45 %) of unsatisfactory hygienic state of oral cavity of examined children and teenagers

LIPID PEROXIDATION PARAMETERS IN BLOOD SERUM AND FOLLICILE LIQUID OF INFERTILE PATIENTS WITH DIFFERENT IVF RESULTS

The article presents the results of investigation of lipid peroxidation parameters in blood serum and follicile liquid of 78 patients with different IVF results. The increase of lipid peroxidation, products is shown in women with unsuccessful IVF procedure

ETHNIC DIFFERENCE OF HEALTH DISORDERS IN INDIGENOUS ETHNIC GROUP OF BAIKAL REGION (LITERATURE REVIEW)

An analysis of the researches showed that the indigenous ethnic group of Baikal region has high level of adaptation to a place of residence in comparison with migrant. Rate and clinical manifestations of diseases in the Buryat ethnic group have significant differences from the Russian (moderate type 1 diabetes, severe reproductive disorders). Also, there are some differences of redox protection state in indigenous ethnic group of Baikal region that could be an additional biochemical marker of disease severity

Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women

Background. It is known that menopausal women suffer from sleep disorders. As additional diagnostic methods, it is possible to use the equations of linear classification functions.Aim: to determine the most informative parameters among the lipid profile, the “lipid peroxidation – antioxidant protection” system parameters and the melatonin secretion chronobiological rhythms in menopausal women with sleep disorders.Materials and methods. 56 perimenopausal women and 70 postmenopausal ones in accordance with the inclusion criteria participated in this study. Diagnoses of insomnia and obstructive sleep apnea syndrome were made according to the results of specialized somnological questionnaires and polysomnographic monitoring. Spectrophotometric methods for studying of lipid metabolism and the “lipid peroxidation – antioxidant protection” system parameters, an enzyme immunoassay method for determining melatonin were also used. A multidimensional discriminant analysis to reveal the most informative parameters among the parameters studied was used.Results. The most informative indicators of the metabolic system for sleep disorders in perimenopausal women with insomnia are melatonin 06.00–07.00 h, melatonin 18.00–19.00 h, melatonin 23.00–00.00 h, ketodienes and conjugated trienes, oxidized glutathione; with insomnia and OSAS – melatonin 06.00–07.00 h, melatonin 12.00–13.00 h, melatonin 23.00–00.00 h, substrates with conjugated double bonds, total cholesterol; in postmenopausal women with insomnia – diene conjugates, α-tocopherol, total antioxidant capacity, active products of thiobarbituric acid, reduced glutathione; with insomnia and OSAS – total antioxidant capacity, α-tocopherol, substrates with conjugated double bonds.Conclusions. The results obtained indicate a great strain in the antioxidant protection system in menopausal women with sleep disorders in response to changes in free radical homeostasis

MENOPAUSE AND SLEEP DISTURBANCES

The article contains the review of literature data of domestic and foreign researchers concerning the issues of climacteric period, in women