137 ancient human genomes from across the Eurasian steppes

Descriptive and Comparative Linguistic

Topical antibiotics for acne treatment

Urgency. Acne is a prevalent polymorphous multifactorial inflammatory disease with various clinical forms ranging from the mildest ones (comedonal) to the most severe forms such as phlegmonous, indurative and cystic acne. According to epidemiology studies, the acne incidence rate in general population varies from 85% to 93%; moreover, there is a trend towards the growth in the incidence rate of postpubertal and persistent acne in adults. Acne treatment methods depend on the adequate clinical assessment of the disease severity, character of eruptions, skin type, any concomitant pathologies and patient’s age. Topical therapy is administered to all patients regardless of the disease severity and forms a mandatory part of the therapeutic complex treatment of acne patients. Despite the range of available drugs and treatment methods, researchers keep searching for new drugs and treatment methods for treating acne. Combination acne therapies enjoy keen interest in the world for reasons such as stable treatment results and improved compliance. It is essential that the administration of a combination therapy came along with drugs having a complimentary mechanism of action. Drug combinations have an effect on a large number of pathogenetic factors resulting in acne (excessive follicular hyperkeratosis, propagation of P. аспвв, inflammation). Goal. The goal of this article is a review of literature sources on current aspects of acne topical therapy and examining results of studies of a combination therapy, azelaic acid and clindamycin. Study materials and methods. The project was carried out at the GBOU VPO Kursk State Medical University, Ministry of Health of the Russian Federation. Major results. Both Russian and foreign authors use combination therapies with topical administration of azelaic acid and clindamycin on a broad scale. According to a study conducted in Russia, azelaic acid is a good combination substance for administration with both topical antibiotics (the antibiotic is to be applied to pustules once a day) and adapalene. According to the clinical study results, 15% azelaic acid (Azelic gel) as a part of a combination topical therapy reduces adverse effects observed in the course of a monotherapy with topical retinoids and improves the therapeutic efficacy when combined with antibacterial drugs. Conclusion. The practical experience and different variants of a combination therapy with 15% azelaic acid (Azelic gel) and 1% clindamycin gel (Clindovit) provide dermatologists with an opportunity to treat acne in different groups of patients on an everyday basis with increased efficacy achieving a longer remission of the inflammatory process

Atherogenic hyperadrenoreactivity in men with arterial hypertension

Aim. То assess the dynamics and interrelations of neuro-humoral and lipid profiles in men with arterial hypertension (AH), based on serum leptin level, adrenoreactivity and lipid profile (ГР) measurement.Material and methods. The study included 60 AH patients aged 30—60 years: 30 men with Stage I-II AH, risk 1—3, and 30 men with AH and diabetes mellitus (DM). In all participants, body mass index (BMI), serum levels of leptin, total cholesterol (TCH), high, low and very low density lipoprotein CH (HDT, TDT and VTDT-CH) were measured, with atherogenicity coefficient (AC) calculated. Sympatho-adrenal system activity was assessed by beta-adrenoreactivity evaluation (red blood cell osmo-resistance in beta-adrenoblocker test).Results. In patients with AH and increased BMI, TP changes manifested in increased TCH, TDT-CH, VTDT-CH and AC levels. In DM-free AH individuals, adrenoreactivity directly correlated with atherogenic lipoprotein levels.Conclusion. In AH patients, atherogenic hyperadrenoreactivity is one of the mechanisms for atherosclerosis development and progression