1,740 research outputs found
Spontaneous Scalarization and Boson Stars
We study spontaneous scalarization in Scalar-Tensor boson stars. We find that
scalarization does not occur in stars whose bosons have no self-interaction. We
introduce a quartic self-interaction term into the boson Lagrangian and show
that when this term is large, scalarization does occur. Strong self-interaction
leads to a large value of the compactness (or sensitivity) of the boson star, a
necessary condition for scalarization to occur, and we derive an analytical
expression for computing the sensitivity of a boson star in Brans-Dicke theory
from its mass and particle number. Next we comment on how one can use the
sensitivity of a star in any Scalar-Tensor theory to determine how its mass
changes when it undergoes gravitational evolution. Finally, in the Appendix, we
derive the most general form of the boson wavefunction that minimises the
energy of the star when the bosons carry a U(1) charge.Comment: 23 pages, 5 postscript figures. Typing errors corrected. Includes
some new text that relates the paper to several previous results. Accepted
for publication in PR
Modeling resilience and sustainability in ancient agricultural systems
The reasons why people adopt unsustainable agricultural practices, and the ultimate environmental implications of those practices, remain incompletely understood in the present world. Archaeology, however, offers unique datasets on coincident cultural and ecological change, and their social and environmental effects. This article applies concepts derived from ecological resilience thinking to assess the sustainability of agricultural practices as a result of long-term interactions between political, economic, and environmental systems. Using the urban center of Gordion, in central Turkey, as a case study, it is possible to identify mismatched social and ecological processes on temporal, spatial, and organizational scales, which help to resolve thresholds of resilience. Results of this analysis implicate temporal and spatial mismatches as a cause for local environmental degradation, and increasing extralocal economic pressures as an ultimate cause for the adoption of unsustainable land-use practices. This analysis suggests that a research approach that integrates environmental archaeology with a resilience perspective has considerable potential for explicating regional patterns of agricultural change and environmental degradation in the past
Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
<p>Abstract</p> <p>Background</p> <p>Microarray Comparative Genomic Hybridization (array CGH) provides a means to examine DNA copy number aberrations. Various platforms, brands and underlying technologies are available, facing the user with many choices regarding platform sensitivity and number, localization, and density distribution of probes.</p> <p>Results</p> <p>We evaluate three different platforms presenting different nature and arrangement of the probes: The Agilent Human Genome CGH Microarray 44 k, the ROMA/NimbleGen Representational Oligonucleotide Microarray 82 k, and the Illumina Human-1 Genotyping 109 k BeadChip, with Agilent being gene oriented, ROMA/NimbleGen being genome oriented, and Illumina being genotyping oriented. We investigated copy number changes in 20 human breast tumor samples representing different gene expression subclasses, using a suite of graphical and statistical methods designed to work across platforms. Despite substantial differences in the composition and spatial distribution of probes, the comparison revealed high overall concordance. Notably however, some short amplifications and deletions of potential biological importance were not detected by all platforms. Both correlation and cluster analysis indicate a somewhat higher similarity between ROMA/NimbleGen and Illumina than between Agilent and the other two platforms. The programs developed for the analysis are available from <url>http://www.ifi.uio.no/bioinf/Projects/</url>.</p> <p>Conclusion</p> <p>We conclude that platforms based on different technology principles reveal similar aberration patterns, although we observed some unique amplification or deletion peaks at various locations, only detected by one of the platforms. The correct platform choice for a particular study is dependent on whether the appointed research intention is gene, genome, or genotype oriented.</p
Subsidence of callotasis zone in distraction osteogenesis after external fixator removal, measured by RSA
Bouncing back from Workplace Stress: From HRD’s Individual Employee’s Developmental Focus to Multi-facetted Collective Workforce Resilience Intervention
A Suborbital Payload for Soft X-ray Spectroscopy of Extended Sources
We present a suborbital rocket payload capable of performing soft X-ray
spectroscopy on extended sources. The payload can reach resolutions of
~100(lambda/dlambda) over sources as large as 3.25 degrees in diameter in the
17-107 angstrom bandpass. This permits analysis of the overall energy balance
of nearby supernova remnants and the detailed nature of the diffuse soft X-ray
background. The main components of the instrument are: wire grid collimators,
off-plane grating arrays and gaseous electron multiplier detectors. This
payload is adaptable to longer duration orbital rockets given its comparatively
simple pointing and telemetry requirements and an abundance of potential
science targets.Comment: Accepted to Experimental Astronomy, 12 pages plus 1 table and 17
figure
Maximum union-free subfamilies
An old problem of Moser asks: how large of a union-free subfamily does every
family of m sets have? A family of sets is called union-free if there are no
three distinct sets in the family such that the union of two of the sets is
equal to the third set. We show that every family of m sets contains a
union-free subfamily of size at least \lfloor \sqrt{4m+1}\rfloor - 1 and that
this bound is tight. This solves Moser's problem and proves a conjecture of
Erd\H{o}s and Shelah from 1972. More generally, a family of sets is
a-union-free if there are no a+1 distinct sets in the family such that one of
them is equal to the union of a others. We determine up to an absolute
multiplicative constant factor the size of the largest guaranteed a-union-free
subfamily of a family of m sets. Our result verifies in a strong form a
conjecture of Barat, F\"{u}redi, Kantor, Kim and Patkos.Comment: 10 page
Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer
background: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer.
methods: The tumour microenvironment was examined using measures of the inflammatory infiltrate (Klintrup-Makinen (KM) grade and Immunoscore), tumour stroma percentage (TSP) and tumour budding. The systemic inflammatory environment was examined using modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR). A 5-year CSS was examined.
results: A total of 331 patients were included. Increasing T stage was associated with colonic primary, N stage, poor differentiation, margin involvement and venous invasion (P<0.05). T stage was significantly associated with KM grade (P=0.001), Immunoscore (P=0.016), TSP (P=0.006), tumour budding (P<0.001), and elevated mGPS and NLR (both P<0.05). In patients with T3 cancer, N stage stratified survival from 88 to 64%, whereas Immunoscore and budding stratified survival from 100 to 70% and from 91 to 56%, respectively. The Glasgow Microenvironment Score, a score based on KM grade and TSP, stratified survival from 93 to 58%.
conclusions: Although associated with increasing T stage, local and systemic tumour environment characteristics, and in particular Immunoscore, budding, TSP and mGPS, are stage-independent determinants of survival and may be utilised in the staging of patients with primary operable colorectal cancer
Gender, age and the MBA: An analysis of extrinsic and intrinsic career benefits
Against the background of an earlier UK study, this paper presents the findings of a Canadian based survey of career benefits from the MBA. Results indicate firstly that gender and age interact to influence perceptions of career outcomes (young men gain most in terms of extrinsic benefits of career change and pay), and secondly that both men and women gain intrinsic benefits from the MBA. However, intrinsic benefits vary by gender: men in the study were more likely to say they gained confidence from having a fuller skill set while women were more likely to say they gained confidence from feelings of self worth; men emphasised how they had learned to give up control while women argued that they had gained a ‘voice’ in the organization. The role of the MBA in career self- management and the acquisition of key skills are examined as well as the implications for the design of programmes in meeting the varied need of men and women in different age groups
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