The path to leadership: the career journey of academic health sciences library directors

Objective: The authors examined the career journeys of academic health sciences library directors to better understand their leadership development and what led them to their leadership positions in libraries. Methods: A qualitative phenomenological approach was employed due to its focus on exploring and understanding the meaning that individuals ascribe to a particular phenomenon or experience. Eleven library directors from academic health sciences libraries at public universities with very high research activity agreed to participate in the study. The research question guiding this study was: What was the library directors’ career journey that led them into library leadership? Results: A major theme that emerged from the data was “Path to Leadership.” Although each participant’s journey was unique, common elements surfaced as they chronicled their careers that were informative as to how they understood their emergence and development as library leaders. The four categories defining this theme were breadth of experience, focused preparation, mentors, and recognition and development of leadership potential. Conclusions: Previous research suggests that leadership development and preparedness are important contributors to leadership effectiveness. It was encouraging to witness and understand the amount of preparation by participants to ready themselves for their roles as library directors. This study provides a comprehensive view of the path to library leadership that furthers understanding of the value of leadership development and preparedness and provides a model for aspiring library leaders

Cobalt(II) acyl intermediates in carbon–carbon bond formation and oxygenation

The organocobalt scorpionate compounds ToMCoR (ToM = tris(4,4-dimethyl-2-oxazolinyl)phenylborate; R = Bn, 1; CH2SiMe3, 2; Ph, 3; Et, 4; nBu, 5; Me, 6) react in carbonylation, oxidation, and carboxylation reactions via pathways that are distinctly influenced by the nature of the organometallic moiety. The compounds are prepared by reaction of ToMCoCl with the corresponding organolithium or organopotassium reagents. Compounds 1–6 were characterized by 8-line hyperfine coupling to cobalt in EPR spectra and solution phase magnetic measurements (μeff = 4–5μB) as containing a high-spin cobalt(II) center. The UV-Vis spectra revealed an intense diagnostic band at ca.700 nm (ε \u3e 1000 M−1 cm−1) associated with the tetrahedral organocobalt(II) center that was assigned to a d ← d transition on the basis of configuration interaction (CI) calculations. Complexes 1–6 react rapidly with CO to form equilibrating mixtures of the low spin organocobalt carbonyl ToMCo(R)CO, acyl ToMCoC(O)R, and acyl carbonyl ToMCo{C(O)R}CO. The 1H and 11B NMR spectra contained only one set of signals for the CO-treated solutions, whereas the solution-phase IR spectra contained up to two νCO and three νC(O)R signals with intensities varying depending on the R group (R = Bn, 7; CH2SiMe3, 8; Ph, 9; Et, 10; nBu, 11; Me, 12). Single crystal X-ray diffraction of ToMCo{C(O)Et}CO (10) supports its assignment as a square pyramidal cobalt(II) acyl carbonyl complex. Upon evaporation of volatiles, solutions of 8–12 revert to the CO-free organocobalt starting materials 2–6, whereas attempts to isolate benzyl-derived 7 provide an unusual α-alkoxyketone species, characterized by single crystal X-ray diffraction. Despite the differences observed in the carbonylation of 1–6 as a result of varying the R group, compounds 7–12 all react rapidly with O2 through an oxygenation pathway to afford the corresponding carboxylate compounds ToMCoO2CR (R = Bn, 13; CH2SiMe3, 14; Ph, 15; Et, 16; nBu, 17; Me, 18). In contrast, the insertion of CO2 into the Co–C bond in 1–6 requires several days to weeks

Visualization of HIV-1 interactions with penile and foreskin epithelia: clues for female-to-male HIV transmission

To gain insight into female-to-male HIV sexual transmission and how male circumcision protects against this mode of transmission, we visualized HIV-1 interactions with foreskin and penile tissues in ex vivo tissue culture and in vivo rhesus macaque models utilizing epifluorescent microscopy. 12 foreskin and 14 cadaveric penile specimens were cultured with R5-tropic photoactivatable (PA)-GFP HIV-1 for 4 or 24 hours. Tissue cryosections were immunofluorescently imaged for epithelial and immune cell markers. Images were analyzed for total virions, proportion of penetrators, depth of virion penetration, as well as immune cell counts and depths in the tissue. We visualized individual PA virions breaching penile epithelial surfaces in the explant and macaque model. Using kernel density estimated probabilities of localizing a virion or immune cell at certain tissue depths revealed that interactions between virions and cells were more likely to occur in the inner foreskin or glans penis (from local or cadaveric donors, respectively). Using statistical models to account for repeated measures and zero-inflated datasets, we found no difference in total virions visualized at 4 hours between inner and outer foreskins from local donors. At 24 hours, there were more virions in inner as compared to outer foreskin (0.0495 +/- 0.0154 and 0.0171 +/- 0.0038 virions/image, p = 0.001). In the cadaveric specimens, we observed more virions in inner foreskin (0.0507 +/- 0.0079 virions/image) than glans tissue (0.0167 +/- 0.0033 virions/image, p<0.001), but a greater proportion was seen penetrating uncircumcised glans tissue (0.0458 +/- 0.0188 vs. 0.0151 +/- 0.0100 virions/image, p = 0.099) and to significantly greater mean depths (29.162 +/- 3.908 vs. 12.466 +/- 2.985 μm). Our in vivo macaque model confirmed that virions can breach penile squamous epithelia in a living model. In summary, these results suggest that the inner foreskin and glans epithelia may be important sites for HIV transmission in uncircumcised men

Accepting the challenge: what academic health sciences library directors do to become effective leaders

Objective: This study sought to better understand effective leadership through the lived experiences of academic health sciences library directors. Methods: Phenomenological interviews were conducted with eight academic health sciences library directors to capture the essence of their shared leadership experiences. The research question that guided the study was: How do academic health sciences library directors understand their leadership effectiveness? The interviews were transcribed and coded, and the data were analyzed thematically. Results: Three main themes emerged from data after analysis: assessment of the environment, strategies and decisions, and critical skills. Assessment of the environment includes awareness not only of trends in libraries and technology, but also the trends in health information, higher education, and current events and politics of their institutions and states. The strategies and decisions theme is about the ability to think both in the long-term and short-term when leading the library. Finally, critical skills are those leadership skills that the research participants identified as most important to their leadership effectiveness. Conclusions: The study identified three main themes capturing the essence of the research participants’ leadership experiences. The three themes constitute a wide array of leadership skills that are important to learn, understand, and develop to increase leadership effectiveness. Effective leadership is fundamental to obtaining long-term strategic goals and is critical to the long-term future of the libraries.  This article has been approved for the Medical Library Association’s Independent Reading Program