Vasoactivity and Vasoconstriction Changes in Cattle Related to Time Off Toxic Endophyte-Infected Tall Fescue

Previous research has indicated that serotonergic and α-adrenergic receptors in peripheral vasculature are affected by exposure of cattle grazing toxic endophyte-infected (E+; Epichlöe coenophialia) tall fescue (Lolium arundinaceum). The objective of this experiment was to determine the period of time necessary for the vascular effects of ergot alkaloids to subside. Two experiments were conducted to investigate changes in vascular contractile response and vasoconstriction over time relative to removal from an ergot alkaloid-containing E+ tall fescue pasture. In Experiment 1, lateral saphenous vein biopsies were conducted on 21 predominantly Angus steers (357 ± 3 kg body weight) at 0 (n = 6), 7 (n = 6), 14 (n = 5), or 28 days (n = 4) after removal from grazing pasture (3.0 ha; endpoint ergovaline + ergovalinine = 1.35 mg/kg DM) for 126 days. In Experiment 2, lateral saphenous veins were biopsied from 24 Angus-cross steers (361 ± 4 kg body weight) at 0, 21, 42, and 63 days (n = 6 per time point) following removal from grazing tall fescue pastures (3.0 ha; first 88 days endpoint ergovaline + ergovalinine = 0.15 mg/kg DM; last 18 days endpoint ergovaline + ergovalinine = 0.57 mg/kg DM) for 106 total days. Six steers (370 ± 18 kg body weight) off of bermudagrass pasture for the same time interval were also biopsied on Day 0 and Day 63 (n = 3 per time point). Additionally, in Experiment 2, cross-sectional ultrasound scans of caudal artery at the fourth coccygeal vertebra were taken on Days 0, 8, 15, 21, 29, 36, 42, and 45 to determine mean artery luminal area to evaluate vasoconstriction. In both experiments, steers were removed from pasture and housed in a dry lot and fed a corn silage diet for the duration of biopsies and ultrasound scans. Biopsied vessels used to evaluate vasoactivity were cleaned, incubated in a multimyograph, and exposed to increasing concentrations of 4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl) methylamine hydrobromide (TCB2; 5HT2A agonist), guanfacine (GF; α2A-adrenergic agonist), and (R)-(+)-m-nitrobiphenyline oxalate (NBP; α2C-adrenergic agonist) in both experiments and ergovaline (ERV) and ergotamine (ERT) in Experiments 1 and 2, respectively. In Experiment 1, days off pasture × agonist concentration was not significant (p \u3e 0.1) for all four compounds tested. In Experiment 2, GF, NBP, TCB2 and ERT were significant for days off pasture × agonist concentration interaction (p \u3c 0.02) and vasoactivity increased over time. Vasoactivity to agonists was reduced (p \u3c 0.05) when steers were initially removed from E+ tall fescue pasture compared to bermudagrass, but did not differ by Day 63 for any variable. Luminal areas of caudal arteries in steers grazed on E+ tall fescue relaxed and were similar to steers that had grazed bermudagrass for 36 days on non-toxic diet (p = 0.15). These data demonstrate changes in peripheral vasoactivity and recovery from vasoconstriction occur beyond five weeks off toxic pasture and 5HT2A receptors appear to be more dramatically affected in the lateral saphenous vein by grazing E+ tall fescue pasture than adrenergic receptors

Unstable states in QED of strong magnetic fields

We question the use of stable asymptotic scattering states in QED of strong magnetic fields. To correctly describe excited Landau states and photons above the pair creation threshold the asymptotic fields are chosen as generalized Licht fields. In this way the off-shell behavior of unstable particles is automatically taken into account, and the resonant divergences that occur in scattering cross sections in the presence of a strong external magnetic field are avoided. While in a limiting case the conventional electron propagator with Breit-Wigner form is obtained, in this formalism it is also possible to calculate $S$-matrix elements with external unstable particles.Comment: Revtex, 7 pages. To appear in Phys. Rev. D53(2

Formal Analysis of Distance Bounding with Secure Hardware

A distance bounding (DB) protocol is a two-party authentication protocol between a prover and a verifier which is based on the distance between the prover and the verifier. It aims to defeat threats by malicious provers who try to convince that they are closer to the verifier or adversaries which seek to impersonate a far-away prover. All these threats are covered in several security definitions and it is not possible to have a single definition covering all. In this paper, we describe a new DB model with three parties where the new party is named hardware. In this model, called secure hardware model (SHM), the hardware is held by the prover without being able to tamper with. We define an all-in-one security model which covers all the threats of DB and an appropriate privacy notion for SHM. In the end, we construct the most efficient (in terms of computation by the prover-hardware and number of rounds) and secure DB protocols achieving the optimal security bounds as well as privacy

X-ray spectra from magnetar candidates. II Resonant cross sections for electron-photon scattering in the relativistic regime

Recent models of spectral formation in magnetars called renewed attention on electron-photon scattering in the presence of ultra-strong magnetic fields. Investigations presented so far mainly focussed on mildly relativistic particles and magnetic scattering was treated in the non-relativistic (Thomson) limit. This allows for consistent spectral calculations up to a few tens of keVs, but becomes inadequate in modelling the hard tails (<200 keV) detected by INTEGRAL from magnetar sources. In this paper, the second in a series devoted to model the X-/soft gamma-ray persistent spectrum of magnetar candidates, we present explicit, relatively simple expressions for the magnetic Compton cross-section at resonance which account for Landau-Raman scattering up to the second Landau level. No assumption is made on the magnetic field strength. We find that sensible departures from the Thomson regime can bealready present at B ~5E12 G. The form of the magnetic cross section we derived can be easily implemented in Monte Carlo transfer codes and a direct application to magnetar spectral calculations will be presented in a forthcoming study.Comment: 14 pages, 5 figures, accepted for publication in MNRA

Private and Secure Public-Key Distance Bounding: Application to NFC Payment

Distance-Bounding is used to defeat relay attacks. For wireless payment systems, the payment terminal is not always online. So, the protocol must rely on a public key for the prover (payer). We propose a generic transformation of a (weakly secure) symmetric distance bounding protocol which has no post-verification into wide-strong-private and secure public-key distance bounding

A Governance Framework for Mitigating Risks and Uncertainty in Collaborative Business Processes

International audienceThe development of collaborative business process relies mostly on software services spanning multiple organizations. Therefore, uncertainty related to the shared assets and risks of Intellectual Property infringement form major concerns and hamper the development of inter-enterprise collaboration. This paper proposes a governance framework to enhance trust and assurance in such collaborative context, coping with the impacts of Cloud infrastructure. First, a collaborative security requirements engineering approach analyzes assets sharing relations in business process, to identify risks and uncertainties and, therefore, elicits partners’ security requirements and profiles. Then, a ‘due usage’ aware policy model supports negotiation between asset provider’s requirements and consumer’s profiles. The enforcement mechanism adapts to dynamic business processes and Cloud infrastructures to provide end-to-end protection on shared assets

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer.

Breast cancer remains the leading cause of cancer death in women owing to metastasis and the development of resistance to established therapies. Macrophages are the most abundant immune cells in the breast tumor microenvironment and can both inhibit and support cancer progression. Thus, gaining a better understanding of how macrophages support cancer could lead to the development of more effective therapies. In this study, we find that breast cancer-associated macrophages express high levels of insulin-like growth factors 1 and 2 (IGFs) and are the main source of IGFs within both primary and metastatic tumors. In total, 75% of breast cancer patients show activation of insulin/IGF-1 receptor signaling and this correlates with increased macrophage infiltration and advanced tumor stage. In patients with invasive breast cancer, activation of Insulin/IGF-1 receptors increased to 87%. Blocking IGF in combination with paclitaxel, a chemotherapeutic agent commonly used to treat breast cancer, showed a significant reduction in tumor cell proliferation and lung metastasis in pre-clinical breast cancer models compared to paclitaxel monotherapy. Our findings provide the rationale for further developing the combination of paclitaxel with IGF blockers for the treatment of invasive breast cancer, and Insulin/IGF1R activation and IGF+ stroma cells as potential biomarker candidates for further evaluation

BVRI Light Curves for 29 Type Ia Supernovae

BVRI light curves are presented for 27 Type Ia supernovae discovered during the course of the Calan/Tololo Survey and for two other SNe Ia observed during the same period. Estimates of the maximum light magnitudes in the B, V, and I bands and the initial decline rate parameter m15(B) are also given.Comment: 17 pages, figures and tables are not included (contact first author if needed), to appear in the Astronomical Journa

S06RS SGR No. 8 (System President)

A Resolution to urge the LSU Board of Supervisors to include student representation on the search committee for the LSU System President