Feed rate modeling in circular–circular interpolation discontinuity for high-speed milling

In this paper, a modeling approach is presented in order to evaluate feed rate during a circular interpolation in high-speed milling. The developed model depends on the type of discontinuity and the kinematic performance of the machine tool. To begin with, a feed rate modeling for circular interpolation with continuity in tangency is developed. After, the discontinuity in tangency between two circular interpolations is replaced by discontinuity in curvature by adding a fillet which is in relation to the functional tolerance ε imposed in the part design. An experimental study has been carried out to validate the models

Observation of slow light in the noise spectrum of a vertical external cavity surface emitting laser

The role of coherent population oscillations is evidenced in the noise spectrum of an ultra-low noise lasers. This effect is isolated in the intensity noise spectrum of an optimized single-frequency vertical external cavity surface emitting laser. The coherent population oscillations induced by the lasing mode manifest themselves through their associated dispersion that leads to slow light effects probed by the spontaneous emission present in the non-lasing side modes.Comment: accepted for publication in Phys. Rev. Let

Cancer Rehabilitation Indicators for Europe

Little is known of cancer rehabilitation needs in Europe. EUROCHIP-3 organised a group of experts to propose a list of population-based indicators used for describing cancer rehabilitation across Europe. The aim of this study is to present and discuss these indicators. A EUROCHIP-3 expert panel reached agreement on two types of indicators. (a) Cancer prevalence indicators. These were proposed as a means of characterising the burden of cancer rehabilitation needs by time from diagnosis and patient health status. These indicators can be estimated from cancer registry data or by collecting data on follow-up and treatments for samples of cases archived in cancer registries. (b) Indicators of rehabilitation success. These include: return to work, quality of life, and satisfaction of specific rehabilitation needs. Studies can be performed to estimate these indicators in individual countries, but to obtain comparable data across European countries it will be necessary to administer a questionnaire to randomly selected samples of patients from population-based cancer registry databases. However, three factors complicate questionnaire studies: patients may not be aware that they have cancer; incomplete participation in surveys could lead to bias; and national confidentiality laws in some cases prohibit cancer registries from approaching patients. Although these studies are expensive and difficult to perform, but as the number of cancer survivors increases, it is important to document their needs in order to provide information on cancer control

Modeling and simulation of high speed milling centers dynamics

High speed machining is a milling operation in industrial production of aeronautic parts, molds and dies. The parts production is being reduced because of the slowing down of the machining resulting from the tool path discontinuity machining strategy. In this article, we propose a simulation tool of the machine dynamic behavior, in complex parts machining. For doing this, analytic models have been developed expressing the cutting tool feed rate. Afterwards, a simulation method, based on numerical calculation tools, has been structured. In order to validate our approach, we have compared the simulation results with the experimental ones, for the same examples

Evaluation of the noise properties of a dual-frequency VECSEL for compact Cs atomic clocks (Poster)

International audienceWe evaluate a dual-frequency and dual-polarization optically-pumped semiconductor laser emitting at 852 nm as a new laser source for compact atomic clocks based on the coherent population trapping (CPT) technique. The frequency difference between the laser modes is tunable to 9.2 GHz corresponding to the ground state hyperfine-split of Cs. Impact of the laser noise has been investigated. Laser relative intensity noise is limited by the pump-RIN transfer to a level of-110 dB/Hz. Laser frequency noise shows excess mechanical and technical noise resulting in a laser linewidth of 1 MHz at 1 s in lock operation. The noise performance and spectral properties of the laser are already adequate to realize CPT experiments and should result in Allan standard-deviation of the clock below 1 × 10-12 at 1 second

Dual-frequency VECSEL for atomic clocks using coherent population trapping

Workshop on Laser Diodes for Space Applications, Nov 2015, Palaiseau, FranceAtomic frequency references provide high-precision stable signals, which are crucial in the most demanding applications as high bitrate communication networks, high-end inertial navigation, or satellite positioning. One way to obtain those laser fields with low intensity-and frequency-noise is to use the dual-frequency and dual-polarization emission of an optically-pumped vertical external-cavity semiconductor laser (OP-VECSEL)

Laser à semiconducteur à 852 nm bifrequence pompé optiquement pour les horloges atomiques CPT (poster)

National audienceNous présentons un laser à semiconducteur en cavité externe pompé optiquement, émettant sur deux fréquences optiques polarisées perpendiculairement, destiné au piégeage cohérent d'atomes (CPT) de Cs. L'émission est accordable autour de 852 nm. La différence de fréquence est ajustée grâce à une lame électro-optique autour de 9,2 GHz. La longueur d'onde du mode ordinaire est stabilisée sur la raie D2 du Cs et la différence de fréquence est asservie sur un signal de référence RF. En fonctionnement stabilisé, nous caractérisons les sources de bruits du laser afin d'évaluer les performances du laser en vue de son application dans une horloge atomique CPT

factors influencing acute and late toxicity in the era of adjuvant hypofractionated breast radiotherapy

Abstract Purpose To evaluate toxicity in breast cancer patients treated with anthracycline and taxane based chemotherapy and whole breast hypofractionated radiotherapy, and to identify the risk factors for toxicity. Methods and materials 537 early breast cancer patients receiving hypofractionated radiotherapy after conservative surgery were enrolled from April 2009 to December 2014, in an Italian cancer institute. The dose was 42.4 Gy in 16 daily fractions, 2.65 Gy per fraction. The boost to the tumor bed was administered only in grade III breast cancer patients and in patients with close or positive margins. Acute and late toxicity were prospectively assessed during and after radiotherapy according to RTOG scale. The impact of patients clinical characteristics, performed treatments and dose inhomogeneities on the occurrence of an higher level of acute skin toxicity and late fibrosis has been evaluated by univariate and multivariate analysis. Results The mean age was 74 (range 46–91 yrs). 27% of patients received boost. 22% of cases (n = 119) received also chemotherapy. The median follow-up was 32 months. G1 and G2/G3 acute skin toxicity were 61.3% and 20.5% and G1 and G2/G3 late fibrosis 12.6% and 4.3% respectively. Chemotherapy (p = 0.04), diabetes (p = 0.04) and boost administration (p Conclusions The results of our study, according to the large randomized trials, confirmed that hypofractionated whole breast irradiation is safe, and only the boost administration seems to be an important predictor for toxicity. Chemotherapy does not impact on acute and late skin toxicity

Efficacy of mRNA anti-SARS-CoV-2 vaccination and dynamics of humoral immune response in patients with solid tumors: results from the institutional registry of an italian tertiary cancer center

Background: Systemic immunosuppression characterizing cancer patients represents a concern regarding the efficacy of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, and real-world evidence is needed to define the efficacy and the dynamics of humoral immune response to mRNA-based anti-SARS-CoV-2 vaccines. Methods: We conducted an observational study that included patients with solid tumors who were candidates for mRNA anti-SARS-CoV-2 vaccination at the Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. The primary objective was to monitor the immunologic response to the mRNA anti-SARS-CoV-2 vaccination in terms of anti-spike antibody levels. All the patients received two doses of the mRNA-1273 vaccine or the BNT162b2 vaccine. Healthcare workers served as a control group of healthy subjects. Results: Among the 243 patients included in the present analysis, 208 (85.60%) and 238 (97.94%) resulted seroconverted after the first and the second dose of vaccine, respectively. Only five patients (2.06%) had a negative titer after the second dose. No significant differences in the rate of seroconversion after two vaccine doses were observed in patients as compared with the control group of healthy subjects. Age and anticancer treatment class had an independent impact on the antibody titer after the second dose of vaccination. In a subgroup of 171 patients with available data about the third timepoint, patients receiving immunotherapy with immune checkpoint inhibitors seem to have a higher peak of antibodies soon after the second dose (3 weeks after), but a more pronounced decrease at a late timepoint (3 months after). Conclusions: The systemic immunosuppression characterizing cancer patients did not seem to dramatically affect the humoral response to anti-SARS-CoV-2 mRNA vaccines in our population of patients with solid tumors. Further investigation is needed to dissect the interplay between immunotherapy and longitudinal dynamics of humoral response to mRNA vaccines, as well as to analyze the cellular response to mRNA vaccines in cancer patients

A three-gene signature marks the time to locoregional recurrence in luminal-like breast cancer

Background: Gene expression profiling (GEP)-based prognostic signatures are being rapidly integrated into clinical decision making for systemic management of breast cancer patients. However, GEP remains relatively underdeveloped for locoregional risk assessment. Yet, locoregional recurrence (LRR), especially early after surgery, is associated with poor survival. Patients and methods: GEP was carried out on two independent luminal-like breast cancer cohorts of patients developing early (≤5 years after surgery) or late (>5 years) LRR and used, by a training and testing approach, to build a gene signature able to intercept women at risk of developing early LRR. The GEP data of two in silico datasets and of a third independent cohort were used to explore its prognostic value. Results: Analysis of the first two cohorts led to the identification of three genes, CSTB, CCDC91 and ITGB1, whose expression, derived by principal component analysis, generated a three-gene signature significantly associated with early LRR in both cohorts (P value <0.001 and 0.005, respectively), overcoming the discriminatory capability of age, hormone receptor status and therapy. Remarkably, the integration of the signature with these clinical variables led to an area under the curve of 0.878 [95% confidence interval (CI) 0.810-0.945]. In in silico datasets we found that the three-gene signature retained its association, showing higher values in the early relapsed patients. Moreover, in the third additional cohort, the signature significantly associated with relapse-free survival (hazard ratio 1.56, 95% CI 1.04-2.35). Conclusions: Our three-gene signature represents a new exploitable tool to aid treatment choice in patients with luminal-like breast cancer at risk of developing early recurrence