Treatment for mixed cognitive impairments and emotional disorders in young and middle-aged patients

Objective: to evaluate the efficacy of Tanakan® (EGB761®) used in young and middle-aged patients with mixed cognitive impairments (CI) and emotional diseases.Patients and methods. An open-label observational study of the efficacy of Tanakan® was conducted in 54 patients aged 18–4 years with CI and psychoemotional disorders. Tanakan® was administered at a daily dose of 120 mg (40 mg t.i.d) for 3 months.Results. Tanakan® therapy resulted in health improvement, as shown by the HAM (Health, Activity, Mood) questionnaire; the mean score of the latter increased from 3.86 at baseline to 4.84 after 3 months of treatment. There were improvements in three HAM questionnaire items: the mean score of the item «Health» increased from 3.69 to 4.79; that of the item «Activity» from 3.65 to 4.58, and that the item «Mood» from 4.25 to 5.14 after the completion of the investigation.Tanakan® therapy also demonstrated improvements in memory (the mean number of correctly repeated words increased from 5.7 to 6.7 at the beginning of a visit and from 4.2 to 5.8 at its end) and in attention (the mean symbol-digit coding test score increased from 48.1 to 55.7%. There were no clinically relevant differences between patients with higher and secondary education in the efficacy of Tanakan®.Conclusion. Tanakan® had a very good safety profile; no adverse drug events were recorded during the investigation. Almost all the 53 (98.1%) of the 54 patients were satisfied with Tanakan® therapy results after 3 months of treatment

Frequently ill children: has everything been resolved?

The article presents an analysis of causes of recurrent respiratory infections in children. The special attention is drawn to the need for improvement of the epidemiological, anamnestic, social and other data to clarify the causes and provoking factors for increased respiratory morbidity. It has been shown that allergic diseases, immunodeficiency states, persistent herpetic infections, functional gastrointestinal disorders, etc. are often hidden.under the mask of “frequently ill children”. This determines the importance of a detailed assessment of clinical manifestations of each episode of the disease and the correct interpretation of examination results for the timely diagnosis specification. It was proposed to move from targeting the “frequently ill children” group to nosological verification, which have a high level of respiratory morbidity. It has been proved that early arriving at a diagnosis makes it possible to timely prescribe etiopathogenetic therapy, which significantly increases the effectiveness of treatment. The article presents an analysis of clinical studies of the effectiveness and safety of OM-85 immunomodulator of bacterial origin in children with recurrent respiratory diseases