The crystal structure of fedotovite, K2Cu30(SO4) 3

Abstract The crystal structure of fcdotovite, K1CU30(S04h has been determined, space group C2/e, a 19.037(6), h 9.479(2), e 14.231(5) A,~1 11.04(3t, Z = 8, Dx = 3.09 g/cm3. The main units of the fedotovite structure are formed around two additional oxygen atoms and consist of edge-sharing [OCU4J tetrahedra and four [S04J tetrahedra attached to them. The units are further connected by two [S04J tetrahedra, building distinct layers parallel to the yz plane. These layers are interconnected by potassium atoms. In the fedotovite structure, the three kinds of copper atoms are fivefold (4 + 1) coordinated to oxygen atoms with a strong Jahn-Teller effect. The coordination polyhedra of Cui and Cu2 atoms are distorted and flattened orthorhombic pyramids with Cu-O distances varying from 1.912 to 2.333 A,. the sixth neighbour of the both atoms is the copper atom lying at 2.975 and 2.981 Afor Cu2 and Cui respectively. The coordination environment of the Cu3 atom is a distorted elongated orthorhombic pyramid with four Cu-O distances from 1.943 to 1.961 A, a fifth at 2.558 A, and further sixth and seventh neighbours (oxygen and copper atoms) at 2.809 and 2.806 A, respectively

Genome-wide Association Study of Long COVID

SummaryInfections can lead to persistent or long-term symptoms and diseases such as shingles after varicella zoster, cancers after human papillomavirus, or rheumatic fever after streptococcal infections1, 2. Similarly, infection by SARS-CoV-2 can result in Long COVID, a condition characterized by symptoms of fatigue and pulmonary and cognitive dysfunction3–5. The biological mechanisms that contribute to the development of Long COVID remain to be clarified. We leveraged the COVID-19 Host Genetics Initiative6, 7to perform a genome-wide association study for Long COVID including up to 6,450 Long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We identified the first genome-wide significant association for Long COVID at theFOXP4locus.FOXP4has been previously associated with COVID-19 severity6, lung function8, and cancers9, suggesting a broader role for lung function in the pathophysiology of Long COVID. While we identify COVID-19 severity as a causal risk factor for Long COVID, the impact of the genetic risk factor located in theFOXP4locus could not be solely explained by its association to severe COVID-19. Our findings further support the role of pulmonary dysfunction and COVID-19 severity in the development of Long COVID.</jats:p