Domains of Archean mantle lithosphere deciphered by seismic anisotropy – inferences from the LAPNET array in northern Fennoscandia

An international LAPNET array (2007–2009, http://www.oulu.fi/sgo-oty/lapnet) of the POLENET/LAPNET sub-project of the POLENET-IPY consortium, related to seismic and geodetic studies in the Arctic regions, consisted of about 60 broadband seismic stations located on the territory of northern Finland and adjacent parts of Sweden, Norway and Russia. We analyze relative P-wave travel-time deviations evaluated for a subset of 90 teleseismic events recorded by the LAPNET array and show examples of lateral variations of shear-wave splitting to demonstrate variability of fabrics of the Archean mantle lithosphere. The initial results clearly demonstrate the Archean mantle lithosphere consists of domains with consistent fabrics reflecting fossil anisotropic structures. 3-D self-consistent anisotropic models with inclined symmetry axes accommodate two independent sets of body-wave anisotropic observations. Individual domains are delimited by boundaries (sutures), where the anisotropic parameters change. The results obtained from the LAPNET array fill a gap in structural studies of the upper mantle beneath northern Fennoscandia

Mantle lithosphere transition from the East European Craton to the Variscan Bohemian Massif imaged by shear-wave splitting

We analyse splitting of teleseismic shear waves recorded during the PASSEQ passive experiment (2006–2008) focused on the upper mantle structure across and around the Trans-European Suture Zone (TESZ). Altogether 1009 pairs of the delay times of the slow split shear waves and orientations of the polarized fast shear waves exhibit lateral variations across the array, as well as back-azimuth dependences of measurements at individual stations. Variable components of the splitting parameters can be associated with fabrics of the mantle lithosphere of tectonic units. In comparison with a distinct regionalization of the splitting parameters in the Phanerozoic part of Europe that particularly in the Bohemian Massif (BM) correlate with the large-scale tectonics, variations of anisotropic parameters around the TESZ and in the East European Craton (EEC) are smooth and of a transitional character. No general and abrupt change in the splitting parameters (anisotropic structure) can be related to the Teisseyre–Tornquist Zone (TTZ), marking the edge of the Precambrian province on the surface. Instead, regional variations of anisotropic structure were found along the TESZ/TTZ. The coherence of anisotropic signals evaluated beneath the northern part of the Brunovistulian in the eastern rim of the BM and the pattern continuation to the NE towards the TTZ, support the idea of a common origin of the lithosphere micro-plates, most probably related to Baltica. Smooth changes in polarizations of the core-mantle boundary refracted shear waves (SKS), polarizations, or even a large number of null splits northward of the BM and further across the TESZ towards the EEC indicate less coherent fabrics and a transitional character of structural changes in the mantle beneath the surface trace of the TESZ/TTZ. The narrow and near-vertical TTZ in the crust does not seem to have a steep continuation in the mantle lithosphere. The mantle part of the TESZ, whose crust was formed by an assemblage of suspect terranes adjoining the EEC edge from the southwest, appears in our measurements of anisotropy as a relatively broad transitional zone in between the two lithospheric segments of different ages. We suggest a southwestward continuation of the Precambrian mantle lithosphere beneath the TESZ and the adjacent Phanerozoic part of Europe, probably as far as towards the Bohemian Massif.Peer reviewe

The subduction structure of the Northern Apennines: results from the RETREAT seismic deployment

The project Retreating-trench, extension, and accretion tectonics, RETREAT, is a multidisciplinary study of the Northern Apennines (earth.geology.yale.edu/RETREAT/), funded by the United States National Science Foundation (NSF) in collaboration with the Italian Istituto Nazionale di Geofisica e Vulcanologia (INGV) and the Grant Agency of the Czech Academy of Sciences (GAAV). The main goal of RETREAT is to develop a self-consistent dynamic model of syn-convergent extension, using the Northern Apennines as a natural laboratory. In the context of this project a passive seismological experiment was deployed in the fall of 2003 for a period of three years. RETREAT seismologists aim to develop a comprehensive understanding of the deep structure beneath the Northern Apennines, with particular attention on inferring likely patterns of mantle flow. Specific objectives of the project are the crustal and lithospheric thicknesses, the location and geometry of the Adriatic slab, and the distribution of seismic anisotropy laterally and vertically in the lithosphere and asthenosphere. The project is collecting teleseismic and regional earthquake data for 3 years. This contribution describes the RETREAT seismic deployment and reports on key results from the first year of the deployment. We confirm some prior findings regarding the seismic structure of Central Italy, but our observations also highlight the complexity of the Northern Apennines subduction system

Rifting in heterogeneous lithosphere inferences from numerical modeling of the northern North Sea and the Oslo Graben.

Permian rifting and magmatism are widely documented across NW Europe. The different Permian basins often display contrasting structural styles and evolved in lithospheric domains with contrasting past evolution and contrasting thermotectonic ages. In particular, the Oslo Graben and the northern North Sea rift initiated in close areas of northern Europe. The Oslo Graben evolved in the cold and stable Precambrian lithosphere of Fennoscandia, whereas the northern North Sea rift took birth in freshly reworked Caledonian lithosphere. Huge volumes of magmatic rocks characterize the relatively narrow Oslo Graben. In contrast, little magmatism is documented for the wide northern North Sea rift. Differences in timing between both rifts are inferred but still debated. We present numerical thermomechanical models along a lithospheric E-W section that involves both the Oslo Graben and the northern North Sea area. Because the modeled section crosses the boundary between Caledonian and Proterozoic provinces, thermal and compositional heterogeneities are considered. As is suggested by various geophysical data sets, we also consider lithospheric thickness heterogeneities in the Precambrian lithosphere. Modeling results suggest that the northern North Sea was on top of "weak" lithosphere very sensitive to far-field stresses. Consequently, we suggest that rifting in the northern North Sea began as early as regional extension was effective (i.e., Late Carboniferous-Early Permian) and does not postdate the Oslo Graben as it is commonly assumed. Rifting in the "strong" Precambrian lithosphere is unexpected. Modeling results suggest that a pre-existing lithospheric thickness contrast within the Fennoscandian lithosphere favored rifting in the Oslo Graben

Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse

Inherited retinal degenerations, collectively termed retinitis pigmentosa (RP), constitute one of the leading causes of blindness in the developed world. RP is at present untreatable and the underlying neurodegenerative mechanisms are unknown, even though the genetic causes are often established. Acetylation and deacetylation of histones, carried out by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively, affects cellular division, differentiation, death and survival. We found acetylation of histones and probably other proteins to be dramatically reduced in degenerating photoreceptors in the rd1 human homologous mouse model for RP. Using a custom developed in situ HDAC activity assay, we show that overactivation of HDAC classes I/II temporally precedes photoreceptor degeneration. Moreover, pharmacological inhibition of HDACs I/II activity in rd1 organotypic retinal explants decreased activity of poly-ADP-ribose-polymerase and strongly reduced photoreceptor cell death. These findings highlight the importance of protein acetylation for photoreceptor cell death and survival and propose certain HDAC classes as novel targets for the pharmacological intervention in RP

Presenilin Controls CBP Levels in the Adult Drosophila Central Nervous System

Background: Dominant mutations in both human Presenilin (Psn) genes have been correlated with the formation of amyloid plaques and development of familial early-onset Alzheimer’s disease (AD). However, a definitive mechanism whereby plaque formation causes the pathology of familial and sporadic forms of AD has remained elusive. Recent discoveries of several substrates for Psn protease activity have sparked alternative hypotheses for the pathophysiology underlying AD. CBP (CREB-binding protein) is a haplo-insufficient transcriptional co-activator with histone acetly-transferase (HAT) activity that has been proposed to be a downstream target of Psn signaling. Individuals with altered CBP have cognitive deficits that have been linked to several neurological disorders. Methodology/Principal Findings: Using a transgenic RNA-interference strategy to selectively silence CBP, Psn, and Notch in adult Drosophila, we provide evidence for the first time that Psn is required for normal CBP levels and for maintaining specific global acetylations at lysine 8 of histone 4 (H4K8ac) in the central nervous system (CNS). In addition, flies conditionally compromised for the adult-expression of CBP display an altered geotaxis behavior that may reflect a neurological defect. Conclusions/Significance: Our data support a model in which Psn regulates CBP levels in the adult fly brain in a manner that is independent of Notch signaling. Although we do not understand the molecular mechanism underlying th

Variation in the Large-Scale Organization of Gene Expression Levels in the Hippocampus Relates to Stable Epigenetic Variability in Behavior

Despite sharing the same genes, identical twins demonstrate substantial variability in behavioral traits and in their risk for disease. Epigenetic factors-DNA and chromatin modifications that affect levels of gene expression without affecting the DNA sequence-are thought to be important in establishing this variability. Epigenetically-mediated differences in the levels of gene expression that are associated with individual variability traditionally are thought to occur only in a gene-specific manner. We challenge this idea by exploring the large-scale organizational patterns of gene expression in an epigenetic model of behavioral variability.To study the effects of epigenetic influences on behavioral variability, we examine gene expression in genetically identical mice. Using a novel approach to microarray analysis, we show that variability in the large-scale organization of gene expression levels, rather than differences in the expression levels of specific genes, is associated with individual differences in behavior. Specifically, increased activity in the open field is associated with increased variance of log-transformed measures of gene expression in the hippocampus, a brain region involved in open field activity. Early life experience that increases adult activity in the open field also similarly modifies the variance of gene expression levels. The same association of the variance of gene expression levels with behavioral variability is found with levels of gene expression in the hippocampus of genetically heterogeneous outbred populations of mice, suggesting that variation in the large-scale organization of gene expression levels may also be relevant to phenotypic differences in outbred populations such as humans. We find that the increased variance in gene expression levels is attributable to an increasing separation of several large, log-normally distributed families of gene expression levels. We also show that the presence of these multiple log-normal distributions of gene expression levels is a universal characteristic of gene expression in eurkaryotes. We use data from the MicroArray Quality Control Project (MAQC) to demonstrate that our method is robust and that it reliably detects biological differences in the large-scale organization of gene expression levels.Our results contrast with the traditional belief that epigenetic effects on gene expression occur only at the level of specific genes and suggest instead that the large-scale organization of gene expression levels provides important insights into the relationship of gene expression with behavioral variability. Understanding the epigenetic, genetic, and environmental factors that regulate the large-scale organization of gene expression levels, and how changes in this large-scale organization influences brain development and behavior will be a major future challenge in the field of behavioral genomics

Genetic Modulation of Rpd3 Expression Impairs Long-Term Courtship Memory in Drosophila

There is increasing evidence that regulation of local chromatin structure is a critical mechanism underlying the consolidation of long-term memory (LTM), however considerably less is understood about the specific mechanisms by which these epigenetic effects are mediated. Furthermore, the importance of histone acetylation in Drosophila memory has not been reported. The histone deacetylase (HDAC) Rpd3 is abundant in the adult fly brain, suggesting a post-mitotic function. Here, we investigated the role of Rpd3 in long-term courtship memory in Drosophila. We found that while modulation of Rpd3 levels predominantly in the adult mushroom body had no observed impact on immediate recall or one-hour memory, 24-hour LTM was severely impaired. Surprisingly, both overexpression as well as RNAi-mediated knockdown of Rpd3 resulted in impairment of long-term courtship memory, suggesting that the dose of Rpd3 is critical for normal LTM