51 research outputs found

    Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases

    Get PDF
    <p>Abstract</p> <p>Background</p> <p>Bronchiectasis is frequently associated (up to 30%) with chronic inflammatory rheumatic diseases and leads to lower respiratory tract infections. Data are lacking on the risk of lower respiratory tract infections in patients treated with biologic agents.</p> <p>Methods</p> <p>Monocenter, retrospective systematic study of all patients with a chronic inflammatory rheumatic disease and concomitant bronchiectasis, seen between 2000 and 2009. Univariate and multivariate analyses were performed to evidence predictive factors of the number of infectious respiratory events.</p> <p>Results</p> <p>47 patients were included (mean age 64.1 ± 9.1 years, 33 (70.2%) women), with a mean follow-up per patient of 4.3 ± 3.1 years. Rheumatoid arthritis was the main rheumatic disease (90.1%). The mean number of infectious events was 0.8 ± 1.0 event per patient-year. The factors predicting infections were the type of treatment (biologic vs. non biologic disease-modifying treatments), with an odds ratio of 8.7 (95% confidence interval: 1.7-43.4) and sputum colonization by any bacteria (odds ratio 7.4, 2.0-26.8). In multivariate analysis, both factors were independently predictive of infections.</p> <p>Conclusion</p> <p>Lower respiratory tract infectious events are frequent among patients receiving biologics for chronic inflammatory rheumatic disease associated with bronchiectasis. Biologic treatment and pre-existing sputum colonization are independent risk factors of infection occurrence.</p

    The Protective Effects of Neighborhood Collective Efficacy on British Children Growing Up in Deprivation: A Developmental Analysis

    No full text
    This article reports on the influence of neighborhood-level deprivation and collective efficacy on children’s antisocial behavior between the ages of 5 and 10 years. Latent growth curve modeling was applied to characterize the developmental course of antisocial behavior among children in the E-Risk Longitudinal Twin Study, an epidemiological cohort of 2,232 children. Children in deprived versus affluent neighborhoods had higher levels of antisocial behavior at school entry (24.1 vs. 20.5, p < .001) and a slower rate of decline from involvement in antisocial behavior between the ages of 5 and 10 (−0.54 vs. −0.78, p < .01). Neighborhood collective efficacy was negatively associated with levels of antisocial behavior at school entry (r =−.10, p < .01) but only in deprived neighborhoods; this relationship held after controlling for neighborhood problems and family-level factors. Collective efficacy did not predict the rate of change in antisocial behavior between the ages of 5 and 10. Findings suggest that neighborhood collective efficacy may have a protective effect on children living in deprived contexts

    The ‘Integration’ of people of Dutch descent in superdiverse neighbourhoods

    No full text
    In the past 40 years, researchers into migration and integration have focussed almost exclusively on migrants and their children. This one-sided focus has persisted, even though it is generally acknowledged that integration is a two-way process in which not only migrants, but also the established population play an important role (see, for example, Garces-Mascareňas and Penninx 2016; Martinovic 2013). Amsterdam and Rotterdam have both become majority-minority cities where now all ethnic population groups – including that of Dutch descent – form a numerical minority. This new reality makes it even more urgent to examine the group without a migration background. In cities like Amsterdam and Rotterdam, only one out of three young people under the age of 15 are of Dutch descent (Crul 2016). The transformation of the former majority group to a numerical minority group may well be one of the most significant urban transformations of our time. The current backlash against migrants and refugees has made it clear that the integration of people of Dutch descent into today’s superdiverse majority-minority neighbourhoods and cities is a topic that begs attention
    • …
    corecore