«Plushkin`s syndrome», or hoarding: between norm and pathology

The article presents an overview of modern psychopathological and path psychological ideas about "Plyushkin's syndrome", pathological accumulation or hoarding in domestic and foreign medical and psychological literature. The possibilities of clinical diagnosing howling as a mental disorder are described, presented in the section "Classification of mental, behavioral disorders and disorders of the nervous system" ICD-11В статье представлен обзор современных психопатологических и патопсихологических представлений о «синдроме Плюшкина», патологическом накопительстве, или хоардинге в отечественной и зарубежной медицинской и психологической литературе. Описаны возможности клинической диагностики хоардинга как психического расстройства, представленного в разделе «Классификация психических, поведенческих расстройств и расстройств развития нервной системы» МКБ-11

Positive effects of breast-feeding

The article considers the short-term and long-term positive effects of breastfeeding on health, identifies the factors that determine women's commitment to breastfeeding, affecting the decision of the mother on the method of feeding the child, analyzes the awareness of young people about the importance of breastfeeding.В статье рассмотрены краткосрочные и долгосрочные положительные эффекты грудного вскармливания на состояние здоровья, определены факторы, определяющие приверженность женщин к грудному вскармливанию, влияющие на принятие решения матери о способе кормления ребёнка, проведён анализ информированности молодежи о важности грудного вскармливани

Latent myocardial damage after cardiopulmonary resuscitation in a teenager without prior cardiac disease

Cardiopulmonary resuscitation is an integral part of intensive care in children and adolescents with a number of diseases, most commonly with congenital heart disease, critical cardiac arrhythmias, or severe traumas. This procedure can cause a number of complications, most of them are still completely unstudied, and many of them are associated with the underlying disease. We have a unique case report of a 14-year-old boy without any cardiac disease, who underwent extensive resuscitative measures, including closed-chest massage, tracheal intubation with mechanical ventilation, as well as a few electrical defibrillations with transient myocardial injury

How Frequently Does out-of Hospital Sudden Unexpected Infants Death Represent the Sudden Infant Death Syndrome?

Background. 19.6 % of all fatal cases among Russian children who died in the first year of life are registered out-of hospital, and they are usually sudden. Out-of-hospital sudden unexpected infant death (OSUID) could be confused with sudden infant death syndrome (SIDS) followed by the wide variation in the diagnostic indicators of the syndrome.The aim of the study is to reveal the pathological changes in the tissues and organs of 420 cases of OSUID (group 1) compared with 350 cases of death in the hospital (group 2), to estimate the conformity of the final diagnoses and to identify cases of OSUID, which were SIDS.Methods. From 2009 to 2016 pathoanatomical and virological study of the organs of 420 cases of OSUID (group 1) and 350 babies who died in a hospital were carried out.Results. It was established that the age of infants of the 1st group at the time of death in 71 % of cases corresponded to the age of SIDS. In terms of gestational age and body weight at birth babies of the 1st group turned out to be much more prosperous. Signs of rapid onset of death in this group: plethora of internal organs (83.3 %) and petechial hemorrhages (75.5 %) were present significantly more often than in the 2nd. In the 1st group, predominantly light acute respiratory viral infections (ARVI) with minimal pathologic signs and pneumonia were diagnosed, but pneumonia in 33.3 % not detected at autopsy. Purulent tracheobronchitis (0 and 21.4 %), bacterial pneumonia (6.3 and 26.3 %), a large area of lung damage (3.8 and 56.1 %) were detected much less frequently in the 1st group. In 38 % of the 1st group, pneumonia was the only cause of death, and in no case in the 2nd. Pathology of the cardiovascular system (55.2 and 87.7 %), central nervous system (58.6 and 90.9 %);urogenital system (34.8 and 62.9), inflammation of the membranes and brain tissue (21.9 and 70.0 %), signs of past or current intrauterine viral infection (29.5 and 64.0 %) in the 1st group was diagnosed much less frequently than in the 2nd, but congenital syphilis, HIV infection and hepatitis C — 3 times more often (12.9 and 3.7 %). The more frequent pathology of the adrenal glands in the 1st group (66.7 and 34 %) could cause inadequate responses to minimal exposure to external factors, including mild acute respiratory viral infections. The diagnosis of SIDS was made in 3 cases and in 3 more it was questionable. However, the presence of multisystemic pathology excludes the diagnosis of SIDS. The diagnosis of SIDS could be established in 30 cases in cases of slight ARVI without intoxication, shock liver or disseminated intravascular coagulation syndrome.Conclusion. The most cases of sudden death occurred in not obvious life-threatening conditions in socially disadvantaged families in the absence of adequate observation, diagnosis and treatment

Possibility of predicting the efficiency of soft tissue sarcoma treatment on the basis of features of their immunological microenvironment

Aim. To study the possibility of using the evaluation of local cellular immunity factors for predicting the efficiency of soft tissue sarcoma treatment. Methods. The study included 38 patients with soft tissue sarcoma: 22 with primary and 16 with recurrent tumors, admitted for surgical treatment in 2014-2016. In all patients, the intraoperative tumor tissue samples, peritumoral zone and relatively intact tissue samples corresponding to the resection lines (a total of 114 samples) were studied to assess the local immunity indices. The tissue samples were homogenized, lymphocyte subsets were detected with a flow cytometer. Results. Characteristics of immunological lymphocytic microenvironment of soft tissue sarcomas were studied in connection with the clinical effect of complex treatment of patients. In primary sarcomas, event-free survival at over 12 months after the surgery was related to higher level of NK-cells in tumor tissue and higher level of NKT-lymphocytes in peritumoral zone and tumor, as well as lower Tregs level than in patients with event-free survival for less than 12 months. In recurrent sarcomas, poor event-free survival was associated with high level of DN-cells in the tumor and peritumoral zone/tumor ratio for CD3+ lymphocytes. All the detected differences were statistically significant (