420 research outputs found
Redefining government's role in agriculture in the nineties
The authors argue that government policies in agriculture have been costly and misdirected worldwide. For them, this inefficiency need not continue. The Urugauy Round is an ideal opportunity for developed and developing nations to strike a bargain. They suggest 1) making agricultural trade subject to the full discipline of the GATT by eliminating waivers and exemptions that have set agricultural commodities apart from other products in their treatment under the GATT, 2) bringing developing countries fully into the GATT, by eliminating their special status, 3) getting all countries to reform their agricultural policies, to reduce the many policy-induced distortions that plague the sector. The authors claim that such a bargain would result in a redefinition of governments'role in agriculture, increased sectoral efficiency nationally, and a more smoothly functioning and tightly knit world agricultural trading system.Crops&Crop Management Systems,Environmental Economics&Policies,Agricultural Knowledge&Information Systems,Economic Theory&Research,Agricultural Research
Specific heat of classical disordered elastic systems
We study the thermodynamics of disordered elastic systems, applied to vortex
lattices in the Bragg glass phase. Using the replica variational method we
compute the specific heat of pinned vortons in the classical limit. We find
that the contribution of disorder is positive, linear at low temperature, and
exhibits a maximum. It is found to be important compared to other
contributions, e.g. core electrons, mean field and non linear elasticity that
we evaluate. The contribution of droplets is subdominant at weak disorder in
.Comment: 4 pages, RevTe
Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug‐Induced Liver Injury
With the application of genetic testing to contemporary medical diagnostics and practice, it has become apparent that the phenotypes of many disorders are modulated by host genetic factors. The aim of the current study was to determine whether selected single nucleotide polymorphisms (SNPs) unrelated to the human leukocyte antigen region or other immune pathways, including those associated with nonalcoholic fatty liver disease (NAFLD), may influence development, severity, or outcomes of drug-induced liver injury (DILI). Thirteen variants previously associated with NAFLD and/or selected other liver diseases were tested in 832 Caucasian DILI cases and 10,397 Caucasian population controls. DILI cases were attributed to multiple agents (177 individual drugs), with 56 cases due to herbal/dietary supplement products. Allele frequencies were imputed from recent genome-wide association studies and compared to those for European control samples from the Gnomad database. Significance was tested by linear regression or logistic regression, depending on the nature of the trait. Any variant that passed the Bonferroni threshold of P < 0.0004 (0.05 13) was considered a significant association. None of the variants proved to be significantly associated with DILI as phenotype nor with any of the selected severity traits. Among the variants studied, rs1421085, found in the fat mass and obesity associated (FTO) gene, showed a marginal protective effect (odds ratio, 0.8; 95% confidence interval, 0.77-0.95; P = 0.005). None of the genetic polymorphisms tested were significantly associated with the risk of development, severity, or outcome of DILI. Conclusion: SNPs implicated in common liver diseases, such as NAFLD, do not play a substantial role in DILI pathogenesis across agents. It remains possible that these variants could be involved with DILI due to single agents, but this will require the evaluation of larger numbers of bona fide cases. (Hepatology Communications 2019;3:1032-1035)
A database of the coseismic effects following the 30 October 2016 Norcia earthquake in Central Italy
We provide a database of the coseismic geological surface effects following the Mw 6.5 Norcia earthquake that hit central Italy on 30 October 2016. This was one of the strongest seismic events to occur in Europe in the past thirty years, causing complex surface ruptures over an area of >400 km 2. The database originated from the collaboration of several European teams (Open EMERGEO Working Group; about 130 researchers) coordinated by the Istituto Nazionale di Geofisica e Vulcanologia. The observations were collected by performing detailed field surveys in the epicentral region in order to describe the geometry and kinematics of surface faulting, and subsequently of landslides and other secondary coseismic effects. The resulting database consists of homogeneous georeferenced records identifying 7323 observation points, each of which contains 18 numeric and string fields of relevant information. This database will impact future earthquake studies focused on modelling of the seismic processes in active extensional settings, updating probabilistic estimates of slip distribution, and assessing the hazard of surface faulting
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