Hierarchically-Attentive RNN for Album Summarization and Storytelling

We address the problem of end-to-end visual storytelling. Given a photo album, our model first selects the most representative (summary) photos, and then composes a natural language story for the album. For this task, we make use of the Visual Storytelling dataset and a model composed of three hierarchically-attentive Recurrent Neural Nets (RNNs) to: encode the album photos, select representative (summary) photos, and compose the story. Automatic and human evaluations show our model achieves better performance on selection, generation, and retrieval than baselines.Comment: To appear at EMNLP-2017 (7 pages

A Joint Speaker-Listener-Reinforcer Model for Referring Expressions

Referring expressions are natural language constructions used to identify particular objects within a scene. In this paper, we propose a unified framework for the tasks of referring expression comprehension and generation. Our model is composed of three modules: speaker, listener, and reinforcer. The speaker generates referring expressions, the listener comprehends referring expressions, and the reinforcer introduces a reward function to guide sampling of more discriminative expressions. The listener-speaker modules are trained jointly in an end-to-end learning framework, allowing the modules to be aware of one another during learning while also benefiting from the discriminative reinforcer's feedback. We demonstrate that this unified framework and training achieves state-of-the-art results for both comprehension and generation on three referring expression datasets. Project and demo page: https://vision.cs.unc.edu/referComment: Some typo fixed; comprehension results on refcocog updated; more human evaluation results adde

Design of algorithms for a dispersive hyperbolic problem

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76793/1/AIAA-1991-1535-868.pd

Fermions in 3D Optical Lattices: Cooling Protocol to Obtain Antiferromagnetism

A major challenge in realizing antiferromagnetic (AF) and superfluid phases in optical lattices is the ability to cool fermions. We determine the equation of state for the 3D repulsive Fermi-Hubbard model as a function of the chemical potential, temperature and repulsion using unbiased determinantal quantum Monte Carlo methods, and we then use the local density approximation to model a harmonic trap. We show that increasing repulsion leads to cooling, but only in a trap, due to the redistribution of entropy from the center to the metallic wings. Thus, even when the average entropy per particle is larger than that required for antiferromagnetism in the homogeneous system, the trap enables the formation of an AF Mott phase.Comment: 4 pages; 5 figures; also see supplementary material in 2 pages with 1 figur

Regulation of wingless and vestigial expression in wing and haltere discs of Drosophila

In the third thoracic segment of Drosophila, wing development is suppressed by the homeotic selector gene Ultrabithorax (Ubx) in order to mediate haltere development. Previously, we have shown that Ubx represses dorsoventral (DV) signaling to specify haltere fate. Here we examine the mechanism of Ubx-mediated downregulation of DV signaling. We show that Wingless (Wg) and Vestigial (Vg) are differentially regulated in wing and haltere discs. In wing discs, although Vg expression in non-DV cells is dependent on DV boundary function of Wg, it maintains its expression by autoregulation. Thus, overexpression of Vg in non-DV cells can bypass the requirement for Wg signaling from the DV boundary. Ubx functions, at least, at two levels to repress Vestigial expression in non-DV cells of haltere discs. At the DV boundary, it functions downstream of Shaggy/GSK3β to enhance the degradation of Armadillo (Arm), which causes downregulation of Wg signaling. In non-DV cells, Ubx inhibits event(s) downstream of Arm, but upstream of Vg autoregulation. Repression of Vg at multiple levels appears to be crucial for Ubx-mediated specification of the haltere fate. Overexpression of Vg in haltere discs is enough to override Ubx function and cause haltere-to-wing homeotic transformations

Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidation

Osteoarthritis (OA) affects a large segment of the aging population and is a major cause of pain and disability. At present, there is no specific treatment available to prevent or retard the cartilage destruction that occurs in OA. Recently, glucosamine sulfate has received attention as a putative agent that may retard cartilage degradation in OA. The precise mechanism of action of glucosamine is not known. We investigated the effect of glucosamine in an in vitro model of cartilage collagen degradation in which collagen degradation induced by activated chondrocytes is mediated by lipid peroxidation reaction. Lipid peroxidation in chondrocytes was measured by conjugated diene formation. Protein oxidation and aldehydic adduct formation were studied by immunoblot assays. Antioxidant effect of glucosamine was also tested on malondialdehyde (thiobarbituric acid-reactive substances [TBARS]) formation on purified lipoprotein oxidation for comparison. Glucosamine sulfate and glucosamine hydrochloride in millimolar (0.1 to 50) concentrations specifically and significantly inhibited collagen degradation induced by calcium ionophore-activated chondrocytes. Glucosamine hydrochloride did not inhibit lipid peroxidation reaction in either activated chondrocytes or in copper-induced oxidation of purified lipoproteins as measured by conjugated diene formation. Glucosamine hydrochloride, in a dose-dependent manner, inhibited malondialdehyde (TBARS) formation by oxidized lipoproteins. Moreover, we show that glucosamine hydrochloride prevents lipoprotein protein oxidation and inhibits malondialdehyde adduct formation in chondrocyte cell matrix, suggesting that it inhibits advanced lipoxidation reactions. Together, the data suggest that the mechanism of decreasing collagen degradation in this in vitro model system by glucosamine may be mediated by the inhibition of advanced lipoxidation reaction, preventing the oxidation and loss of collagen matrix from labeled chondrocyte matrix. Further studies are needed to relate these in vitro findings to the retardation of cartilage degradation reported in OA trials investigating glucosamine