Supergravity on R4 x S1/Z2 and singular Calabi-Yaus

We discuss the moduli space singularities that are generally present in five-dimensional vector-coupled supergravity on a spactime of the form R4 x S1/Z2, with vector fields surviving on the Z2 fixed planes. The framework of supergravity is necessarily ambiguous when it comes to the non-singular embedding theory, so we focus on those models coming from Calabi-Yau three-folds with wrapped membranes.Comment: 13 p

Decision problems, complexity, traces, and representations

In this article, we study connections between representation theory and efficient solutions to the conjugacy problem on infinitely generated groups. The main focus is on the conjugacy problem in conjugacy separable groups, where we measure efficiency in terms of the size of the quotients required to distinguish a distinct pair of conjugacy classes

Effects of ignorance and information on judgments and decisions

We compared Turkish and English students’ soccer forecasting for English soccer matches. Although the Turkish students knew very little about English soccer, they selected teams on the basis of familiarity with the team (or its identified city); their prediction success was surprisingly similar to knowledgeable English students—consistent with Goldstein and Gigerenzer’s (1999; 2002) characterization of the recognition heuristic. The Turkish students made forecasts for some of the matches with additional information—the half-time scores. In this and a further study, where British students predicting matches for foreign teams could choose whether or not to use half-time information, we found that predictions that could be made by recognition alone were influenced by the half-time information. We consider the implications of these findings in the context of Goldstein and Gigerenzer’s (2002, p. 82) suggestion that “. . . no other information can reverse the choice determined by recognition” and a recent more qualified statement (Gigerenzer & Goldstein, 2011

Probabilistic computer model of optimal runway turnoffs

Landing delays are currently a problem at major air carrier airports and many forecasters agree that airport congestion will get worse by the end of the century. It is anticipated that some types of delays can be reduced by an efficient optimal runway exist system allowing increased approach volumes necessary at congested airports. A computerized Probabilistic Runway Turnoff Model which locates exits and defines path geometry for a selected maximum occupancy time appropriate for each TERPS aircraft category is defined. The model includes an algorithm for lateral ride comfort limits

Ionic effects on the membrane potential of hyperpolarizing photoreceptor in scallop retina

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109976/1/tjp19782751345.pd

CARMA: A platform for analyzing microarray datasets that incorporate replicate measures

BACKGROUND: The incorporation of statistical models that account for experimental variability provides a necessary framework for the interpretation of microarray data. A robust experimental design coupled with an analysis of variance (ANOVA) incorporating a model that accounts for known sources of experimental variability can significantly improve the determination of differences in gene expression and estimations of their significance. RESULTS: To realize the full benefits of performing analysis of variance on microarray data we have developed CARMA, a microarray analysis platform that reads data files generated by most microarray image processing software packages, performs ANOVA using a user-defined linear model, and produces easily interpretable graphical and numeric results. No pre-processing of the data is required and user-specified parameters control most aspects of the analysis including statistical significance criterion. The software also performs location and intensity dependent lowess normalization, automatic outlier detection and removal, and accommodates missing data. CONCLUSION: CARMA provides a clear quantitative and statistical characterization of each measured gene that can be used to assess marginally acceptable measures and improve confidence in the interpretation of microarray results. Overall, applying CARMA to microarray datasets incorporating repeated measures effectively reduces the number of gene incorrectly identified as differentially expressed and results in a more robust and reliable analysis

Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking

Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood. Studies suggest that stress may “set the stage” for relapse by increasing the sensitivity of brain reward circuits to drug-associated stimuli. We examined the effects of stress and corticosterone on behavioral and neurochemical responses of rats to a cocaine prime after cocaine self-administration and extinction. Exposure of rats to acute electric footshock stress did not by itself reinstate drug-seeking behavior but potentiated reinstatement in response to a subthreshold dose of cocaine. This effect of stress was not observed in adrenalectomized animals, and was reproduced in nonstressed animals by administration of corticosterone at a dose that reproduced stress-induced plasma levels. Pretreatment with the glucocorticoid receptor antagonist RU38486 did not block the corticosterone effect. Corticosterone potentiated cocaine-induced increases in extracellular dopamine in the nucleus accumbens (NAc), and pharmacological blockade of NAc dopamine receptors blocked corticosterone-induced potentiation of reinstatement. Intra-accumbens administration of corticosterone reproduced the behavioral effects of stress and systemic corticosterone. Corticosterone treatment acutely decreased NAc dopamine clearance measured by fast-scan cyclic voltammetry, suggesting that inhibition of uptake2-mediated dopamine clearance may underlie corticosterone effects. Consistent with this hypothesis, intra-accumbens administration of the uptake2 inhibitor normetanephrine potentiated cocaine-induced reinstatement. Expression of organic cation transporter 3, a corticosterone-sensitive uptake2 transporter, was detected on NAc neurons. These findings reveal a novel mechanism by which stress hormones can rapidly regulate dopamine signaling and contribute to the impact of stress on drug intake