A Survey of Lentic Waters with Respect to Dissolved and Particulate Lead

Some of the strongest temperature inversions in the world occur at Fairbanks, Alaska. Benson (1970) has reported that a temperature gradient of 10 to 30C/1OO m is common in the winter inversions that form at Fairbanks. Air pollution is especially severe during these inversions when it is accompanied by the formation of ice crystals in the air, a condition known as ice fog. This phenomenon occurs when the temperature drops below -20F (-35C) (Benson, 1970), and it intensifies with time if the inversion is not broken. The ice crystals in this fog have been found to adsorb dust and gasses, including the lead halides which are present in the air as a result of the combustion of tetraethyl lead and/or other lead-hydrocarbon compounds used as anti-knock additives in automotive gasoline. Lazrus et al. (1970) have found lead concentrations in precipitation to be highly significantly correlated with the amount of gasoline used in the area sampled. There are two factors that bring the concentration of lead to high levels in ice fogs. Evaporation of the ice crystals tends to concentrate pollutants in the air mass, especially over the core area of the city where precipitation is retarded by the heating effect of the city. Also, during the extreme cold weather accompanying this phenomenon, many people allow their cars to idle when they are parked to increase performance and for reasons of personal comfort. Eventually, much of the pollutants suspended in the ice fog is precipitated and causes unnaturally high levels of lead in the snow. (Winchester et al., 1967). It is suspected that some of this particulate lead collected in the snow may be carried along with the associated surface runoff into 1entic (standing) surface waters during thawing. The objectives of this project were: 1. to measure the amount of dissolved and particulate lead in a number of selected 1entic waters in the Fairbanks area, and 2. to measure the amount of lead that has been incorporated into net plankton organisms located in the selected lentic waters.The work upon which this report is based was supported by funds (Project A-035-ALAS) provided by the United States Department of the Interior, Office of Water Resources Research, as authorized under the Water Resources Act of 1964, as amended

Nutrient chemistry of a large, deep lake in subarctic Alaska

Project Officer Eldor W. Schallock Assessment and Criteria Development Division Corvallis Environmental Research Laboratory Corvallis, Oregon 97330;Corvallis Environmental Research Laboratory Office of Research and Development U. S. Environmental Protection Agency Corvallis, Oregon 97330; R800276The primary objective of this project was to assess the state of the water quality of Harding Lake, and to attempt to predict the effects of future development within its watershed. Since the major effect of degradation of water quality due to human activity is the promotion of nuisance growths of plants, the major emphasis was placed on measurements of plant growth and concentrations of the major nutrients they require. Planktonic algal growth was found to be low, below 95.6 gm/m2/year, and the growth of submerged rooted plants was found to be relatively less important at approximately 1.35 gm/m2/year. Measurements of the growth of attached algae were not conducted, therefore the relative importance of their growth is currently unknown. A model for predicting the effect of future real estate development in the watershed was modified and applied to this lake. This model adequately describes current water quality conditions, and is assumed to have some predictive ability, but several cautions concerning application of this model to Harding Lake are discussed. A secondary objective was to study the thermal regime of a deep subarctic lake. Intensive water temperature measurements were made throughout one year and less intensive measurements were conducted during two additional years. The possibility that this lake may occasionally stratify thermally under the ice and not mix completely in the spring was discovered. The implications of this possibility are discussed for management of subarctic lakes. Hydrologic and energy budgets of this lake are attempted; the annual heat budget is estimated at 1.96 x 104 ± 1.7 x 103 cal/cm2. The results of a study of domestic water supply and waste disposal alternatives in the watershed, and the potential for enteric bacterial contamination of the lake water are presented. Limited work on the zooplankton, fishes, and benthic macroinvertebrates of this lake is also presented

Use of LANDSAT imagery for wildlife habitat mapping in northeast and eastcentral Alaska

There are no author-identified significant results in this report

Radiosurgery for brainstem metastases with and without whole brain radiotherapy: clinical series and literature review

Objective The objective of this study was to investigate outcomes for patients with brainstem metastases treated with stereotactic radiosurgery (SRS). Methods Patients with brainstem metastases treated with SRS between April 2006 and June 2012 were identified from a prospective database. Patient and treatment-related factors were recorded. Kaplan-Meier analysis was used to calculate survival and freedom from local and distant brain progression. Univariate and multivariate Cox regression was used to identify factors important for overall survival. Results In total, 44 patients received SRS for 48 brainstem metastases of whom 33 (75 %) also received whole brain radiotherapy (WBRT): 23 patients (52 %) WBRT prior to SRS, 6 (13.6 %) WBRT concurrently with SRS and 4 (9.0 %) WBRT after SRS. Eight patients received a second course ofWBRTat further progression. Median target volume was 1.33 cc (range 0.04–12.17) and median prescribed marginal dose was 15 Gy (range 10–22). There were four cases of local failure, and 6-month and 1-year freedom from local failure was 84.6 and 76.9 %, respectively. Median overall survival (OS) was 5.4 months. There were four cases of radionecrosis, 2 (4.8 %) of which were symptomatic. The absence of external beam brain radiotherapy (predominantly WBRT) showed a trend towards improved OS on univariate analysis. Neither local nor distant brain failure significantly impacted OS. Conclusion This retrospective series of patients treated with SRS for brainstem metastases, largely in combination with at least one course of WBRT, demonstrates that this approach is safe and results in good local control. In this cohort, no variables significantly impacted OS, including intracranial control

Research and Innovation Supporting the Farm to Fork Strategy of the European Commission

The EU Think Tank (as part of the FIT4FOOD2030 Coordination andSupport Action) strongly supports the development of the Farm toFork Strategy as a key component of the European Green Deal,recognising the need to transform the food system as a whole

Gliosarcoma: a study of four cases

Gliosarcomas (GS) are highly malignant and rare tumors of the central nervous system with a poor prognosis. We report here on four patients with GS, the median survival for whom was 9.25 months. Prognosis of GS remains poor, and a multidisciplinary approach (surgery, radiation therapy, and chemotherapy) seems to be associated with slightly more prolonged survival times

Craniospinal irradiation as part of re-irradiation for children with recurrent intracranial ependymoma

Background: The goal of this study was to evaluate outcomes in children with relapsed, molecularly characterized intracranial ependymoma treated with or without craniospinal irradiation (CSI) as part of a course of repeat radiation therapy (re-RT). Methods: This was a retrospective cohort study of 31 children. Patients with distant relapse received CSI as part of re-RT. For patients with locally recurrent ependymoma, those treated before 2012 were re-irradiated with focal re-RT. In 2012, institutional practice changed to offer CSI, followed by boost re-RT to the site of resected or gross disease. Results: Median follow-up was 5.5 years. Of 9 patients with distant relapse after initial RT, 2-year freedom from progression (FFP) and overall survival (OS) were 12.5% and 62.5%, respectively. There were 22 patients with local failure after initial RT. In these patients, use of CSI during re-RT was associated with improvement in 5-year FFP (83.3% with CSI vs 15.2% with focal re-RT only, P = 0.030). In the subgroup of patients with infratentorial primary disease, CSI during re-RT also improved 5-year FFP (100% with CSI, 10.0% with focal re-RT only, P = 0.036). Twenty-three patients had known molecular status; all had posterior fossa group A tumors (n = 17) or tumors with a RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A) fusion (n = 6). No patient developed radiation necrosis after fractionated re-RT, though almost all survivors required assistance throughout formal schooling. Five out of 10 long-term survivors have not developed neuroendocrine deficits. Conclusions: Re-irradiation with CSI is a safe and effective treatment for children with locally recurrent ependymoma and improves disease control compared with focal re-irradiation, with the benefit most apparent for those with infratentorial primary tumors

The appropriateness of gatekeeping in the provision of reproductive health care for adolescents in Lithuania:the general practice perspective

BACKGROUND: Adolescents' consultation of primary health care services remains problematic despite their accessibility. The reproductive health service seeking behavior of adolescents is the object of much research but little is known about how this behavior is influenced by the gatekeeping system. This study aimed to explore general practitioners' perceptions of the appropriateness of gatekeeping in adolescent reproductive health care. METHODS: Twenty in-depth interviews regarding factors affecting adolescent reproductive health care were carried out on a diverse sample of general practitioners and analyzed using grounded theory. RESULTS: The analysis identified several factors that shaped GPs' negative attitude to gatekeeping in adolescent reproductive health care. Its appropriateness in this field was questionable due to a lack of willingness on the part of GPs to provide reproductive health services for teenagers, their insufficient training, inadequately equipped surgeries and low perceived support for reproductive health service provision. CONCLUSION: Since factors for improving adolescent reproductive health concern not only physicians but also the health system and policy levels, complex measures should be designed to overcome these barriers. Discussion of a flexible model of gatekeeping, encompassing both co-ordination of care provided by GPs and the possibility of patients' self-referral, should be included in the political agenda. Adolescents tend to under-use rather than over-use reproductive health services and every effort should be made to facilitate the accessibility of such services

A dimensioning and tolerancing methodology for concurrent engineering applications I: problem representation

This paper is the first of two which present a methodology for determining the dimensional specifications of all the component parts and sub-assemblies of a product according to their dimensional requirements. To achieve this goal, two major steps are followed, each of which is described in a paper. In the first paper, all relationships necessary for finding the values of dimensions and tolerances are represented in a matrix form, known as a Dimensional Requirements/Dimensions (DR/D) matrix. In the second paper, the values of individual dimensions and tolerances are determined by applying a comprehensive solution strategy to satisfy all the relationships represented in the DR/D matrix. The methodology is interactive and suitable for use in a concurrent engineering (CE) environment. The graphical tool presented in this paper will assist a CE team in visualizing the overall D&T problem and foreseeing the ramifications of decisions regarding the selection of dimensions and tolerances. This will assist the CE team to systematically determine all the controllable variables, such as dimensions, tolerances, and manufacturing processes

Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma

<p>Abstract</p> <p>Background</p> <p>Glioblastoma is the most common brain tumor in adults. The mechanisms leading to glioblastoma are not well understood but animal studies support that inactivation of tumor suppressor genes in neural stem cells (NSC) is required and sufficient to induce glial cancers. This suggests that the NSC niches in the brain may harbor cancer stem cells (CSCs), Thus providing novel therapy targets. We hypothesize that higher radiation doses to these NSC niches improve patient survival by eradicating CSCs.</p> <p>Methods</p> <p>55 adult patients with Grade 3 or Grade 4 glial cancer treated with radiotherapy at UCLA between February of 2003 and May of 2009 were included in this retrospective study. Using radiation planning software and patient radiological records, the SVZ and SGL were reconstructed for each of these patients and dosimetry data for these structures was calculated.</p> <p>Results</p> <p>Using Kaplan-Meier analysis we show that patients whose bilateral subventricular zone (SVZ) received greater than the median SVZ dose (= 43 Gy) had a significant improvement in progression-free survival if compared to patients who received less than the median dose (15.0 vs 7.2 months PFS; P = 0.028). Furthermore, a mean dose >43 Gy to the bilateral SVZ yielded a hazard ratio of 0.73 (P = 0.019). Importantly, similarly analyzing total prescription dose failed to illustrate a statistically significant impact.</p> <p>Conclusions</p> <p>Our study leads us to hypothesize that in glioma targeted radiotherapy of the stem cell niches in the adult brain could yield significant benefits over radiotherapy of the primary tumor mass alone and that damage caused by smaller fractions of radiation maybe less efficiently detected by the DNA repair mechanisms in CSCs.</p