Trapping effects on inflation

We develop a Lagrangian approach based on the influence functional method so as to derive self-consistently the Langevin equation for the inflaton field in the presence of trapping points along the inflaton trajectory. The Langevin equation exhibits the backreaction and the fluctuation-dissipation relation of the trapping. The fluctuation is induced by a multiplicative colored noise that can be identified as the the particle number density fluctuations and the dissipation is a new effect that may play a role in the trapping with a strong coupling. In the weak coupling regime, we calculate the power spectrum of the noise-driven inflaton fluctuations for a single trapping point and studied its variation with the trapping location. We also consider a case with closely spaced trapping points and find that the resulting power spectrum is blue.Comment: 13 pages, 2 figure

Possible Constraints on the Duration of Inflationary Expansion from Quantum Stress Tensor Fluctuations

We discuss the effect of quantum stress tensor fluctuations in deSitter spacetime upon the expansion of a congruence of timelike geodesics. We treat a model in which the expansion fluctuations begin on a given hypersurface in deSitter spacetime, and find that this effect tends to grow, in contrast to the situation in flat spacetime. This growth potentially leads to observable consequences in inflationary cosmology in the form of density perturbations which depend upon the duration of the inflationary period. In the context of our model, the effect may be used to place upper bounds on this duration.Comment: 21 pages, no figures; Sect. IV rewritten and expanded, several comments and references adde

Gravity Waves from Quantum Stress Tensor Fluctuations in Inflation

We consider the effects of the quantum stress tensor fluctuations of a conformal field in generating gravity waves in inflationary models. We find a non-scale invariant, non-Gaussian contribution which depends upon the total expansion factor between an initial time and the end of inflation. This spectrum of gravity wave perturbations is an illustration of a negative power spectrum, which is possible in quantum field theory. We discuss possible choices for the initial conditions. If the initial time is taken to be sufficiently early, the fluctuating gravity waves are potentially observable both in the CMB radiation and in gravity wave detectors, and could offer a probe of transplanckian physics. The fact that they have not yet been observed might be used to constrain the duration and energy scale of inflation.Comment: 17 -pages, no figure

Automated targeting approach for synthesis of heat exchanger network (HEN) with trigeneration system

AbstractIn this work, a novel systematic approach for the synthesis of heat exchanger network (HEN) with trigeneration system via multiple cascades automated targeting (MCAT) is presented. The optimisation objective is to locate the minimum total operating cost (TOC) of the system. The minimum hot and cold utilities of the HEN, allocation of utilities and potential power generation as well as the type of fuel can be determined via proposed approach. A case study of formic acid processing plant is solved to illustrate proposed approach

Quantum Stress Tensor Fluctuations of a Conformal Field and Inflationary Cosmology

We discuss the additional perturbation introduced during inflation by quantum stress tensor fluctuations of a conformally invariant field such as the photon. We consider both a kinematical model, which deals only with the expansion fluctuations of geodesics, and a dynamical model which treats the coupling of the stress tensor fluctuations to a scalar inflaton. In neither model do we find any growth at late times, in accordance with a theorem due to Weinberg. What we find instead is a correction which becomes larger the earlier one starts inflation. This correction is non-Gaussian and highly scale dependent, so the absence of such effects from the observed power spectra may imply a constraint on the total duration of inflation. We discuss different views about the validity of perturbation theory at very early times during which currently observable modes are transplanckian.Comment: 31 pages, 1 figure, uses LaTeX2epsilo

Quantum Stress Tensor Fluctuation Effects in Inflationary Cosmology

We review several related investigations of the effects of the quantum stress tensor of a conformal field in inflationary cosmology. Particular attention will be paid to the effects of quantum stress tensor fluctuations as a source of density and tensor perturbations in inflationary models. These effects can possibly depend upon the total expansion factor during inflation, and hence be much larger than one might otherwise expect. They have the potential to contribute a non-scale invariant and non-Gaussian component to the primordial spectrum of perturbations, and might be observable.Comment: 8 pages, proceedings of IARD 2010, Conference on Classical and Quantum Relativistic Dynamics of Particles and Fields, Hualien, Taiwan May 201

Neutrino Masses in the Supersymmetric Standard Model with Right-Handed Neutrinos and Spontaneous R-Parity Violation

We propose an extension of the supersymmetric standard model with right-handed neutrinos and a singlet Higgs field, and study the neutrino masses in this model. The Majorana masses for the right-handed neutrinos are generated around the supersymmetry breaking scale through the vacuum expectation value of the singlet Higgs field. This model may induce spontaneous R-parity violation via the vacuum expectation value of the right-handed sneutrino. In the case, the effective theory is similar to a bilinear R-parity violating model. There are two sources for the neutrino masses: one is this bilinear R-parity breaking effect, and the other is the ordinary seesaw effect between left- and right-handed neutrinos. Combining these two effects, the hierarchical neutrino mass pattern arises even when the neutrino Yukawa matrices are not hierarchical. We acquire appropriate masses and mixings to explain both the solar and atmospheric neutrino oscillations.Comment: 22pages, RevTeX, 3 ps figures; a reference adde

Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults

BACKGROUND: Studying cytokine/chemokine responses in severe influenza infections caused by different virus subtypes may improve understanding on pathogenesis. METHODS: Adults hospitalized for laboratory-confirmed seasonal and pandemic 2009 A/H1N1 (pH1N1) influenza were studied. Plasma concentrations of 13 cytokines/chemokines were measured at presentation and then serially, using cytometric-bead-array with flow-cytometry and ELISA. PBMCs from influenza patients were studied for cytokine/chemokine expression using ex-vivo culture (Whole Blood Assay,±PHA/LPS stimulation). Clinical variables were prospectively recorded and analyzed. RESULTS: 63 pH1N1 and 53 seasonal influenza patients were studied. pH1N1 patients were younger (mean±S.D. 42.8±19.2 vs 70.5±16.7 years), and fewer had comorbidities. Respiratory/cardiovascular complications were common in both groups (71.4% vs 81.1%), although severe pneumonia with hypoxemia (54.0% vs 28.3%) and ICU admissions (25.4% vs 1.9%) were more frequent with pH1N1. Hyperactivation of the proinflammatory cytokines IL-6, CXCL8/IL-8, CCL2/MCP-1 and sTNFR-1 was found in pH1N1 pneumonia (2-15 times normal) and in complicated seasonal influenza, but not in milder pH1N1 infections. The adaptive-immunity (Th1/Th17)-related CXCL10/IP-10, CXCL9/MIG and IL-17A however, were markedly suppressed in severe pH1N1 pneumonia (2-27 times lower than seasonal influenza; P-values<0.01). This pattern was further confirmed with serial measurements. Hypercytokinemia tended to be sustained in pH1N1 pneumonia, associated with a slower viral clearance [PCR-negativity: day 3-4, 55% vs 85%; day 6-7, 67% vs 100%]. Elevated proinflammatory cytokines, particularly IL-6, predicted ICU admission (adjusted OR 12.6, 95%CI 2.6-61.5, per log(10)unit increase; P = 0.002), and correlated with fever, tachypnoea, deoxygenation, and length-of-stay (Spearman's rho, P-values<0.01) in influenza infections. PBMCs in seasonal influenza patients were activated and expressed cytokines ex vivo (e.g. IL-6, CXCL8/IL-8, CCL2/MCP-1, CXCL10/IP-10, CXCL9/MIG); their 'responsiveness' to stimuli was shown to change dynamically during the illness course. CONCLUSIONS: A hyperactivated proinflammatory, but suppressed adaptive-immunity (Th1/Th17)-related cytokine response pattern was found in severe pH1N1 pneumonia, different from seasonal influenza. Cytokine/immune-dysregulation may be important in its pathogenesis

Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles

Background 4-substituted methylidene oxindoles are pharmacologically important. Detailed analysis and comparison of all the interactions present in crystal structures is necessary to understand how these structures arise. The XPac procedure allows comparison of complete crystal structures of related families of compounds to identify assemblies that are mainly the result of close-packing as well as networks of directed interactions. Results Five 4-substituted methylidene oxindoles have been synthesized by the Knoevenagel condensation of oxindole with para-substituted aromatic aldehydes and were characterized in the solid state by x-ray crystallography. Hence, the structures of (3E)-3-(4-Bromobenzylidene)-1,3-dihydro-2H-indol-2-one, 3a, (3E)-3-(4-Chlorobenzylidene)-1,3-dihydro-2H-indol-2-one, 3b, (3E)-3-(4-Methoxybenzylidene)-1,3-dihydro-2H-indol-2-one, 3c, (3E)-3-(4-Methylbenzylidene)-1,3-dihydro-2H-indol-2-one, 3d and (3E)-3-(4-Nitrobenzylidene)-1,3-dihydro-2H-indol-2-one, 3e, were elucidated using single crystal X-ray crystallography. Conclusions A hydrogen bonded dimer molecular assembly or supramolecular construct was identified in all the crystal structures examined along with a further four 1D supramolecular constructs which were common to at least two of the family of structures studied. The 1D supramolecular constructs indicate that once the obvious strong interaction is satisfied to form hydrogen bonded dimer it is the conventionally weaker interactions, such as steric bulk and edge-to-face interactions which compete to influence the final structure formation

Systematic comparison of plasma EBV DNA, anti-EBV antibodies and miRNA levels for early detection and prognosis of nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is originated from the epithelial cells of nasopharynx, Epstein-Barr virus (EBV)-associated and has the highest incidence and mortality rates in Southeast Asia. Late presentation is a common issue and early detection could be the key to reduce the disease burden. Sensitivity of plasma EBV DNA, an established NPC biomarker, for Stage I NPC is controversial. Most newly reported NPC biomarkers have neither been externally validated nor compared to the established ones. This causes difficulty in planning for cost-effective early detection strategies. Our study systematically evaluated six established and four new biomarkers in NPC cases, population controls and hospital controls. We showed that BamHI-W 76 bp remains the most sensitive plasma biomarker, with 96.7% (29/30), 96.7% (58/60) and 97.4% (226/232) sensitivity to detect Stage I, early stage and all NPC, respectively. Its specificity was 94.2% (113/120) against population controls and 90.4% (113/125) against hospital controls. Diagnostic accuracy of BamHI-W 121 bp and ebv-miR-BART7-3p were validated. Hsa-miR-29a-3p and hsa-miR-103a-3p were not, possibly due to lower number of advanced stage NPC cases included in this subset. Decision tree modeling suggested that combination of BamHI-W 76 bp and VCA IgA or EA IgG may increase the specificity or sensitivity to detect NPC. EBNA1 99 bp could identify NPC patients with poor prognosis in early and advanced stage NPC. Our findings provided evidence for improvement in NPC screening strategies, covering considerations of opportunistic screening, combining biomarkers to increase sensitivity or specificity and testing biomarkers from single sampled specimen to avoid logistic problems of resampling