Chlorpromazine reduces avoidance performance deficit in rats with dorsomedial thalamic lesions

Rats with bilateral lesions of the dorsomedial area of the thalamus were shown to have a significant performance deficit on the acquisition of a one-way active shock-avoidance task relative to sham-operated controls. Administration of chlorpromazine prior to testing was shown to reduce this deficit among the DMT-lesioned animals

While a Monkey Waits: Electrocortical Events Recorded During the Foreperiod of a Reaction Time Study

Electrical potentials in frontal, motor and parietal cortex of young rhesus monkeys during three foreperiod reaction time tasks were studied using transcortical Pt-PtCl electrodes, long time-constant amplifiers and computer-averaging techniques. A prominent positive-negative-positive wave form was observed maximally in postcentral cortex when monkeys held a key down during a fixed interval between two stimuli. When response was withheld until the second stimulus, sustained negativity occurred frontally but not postcentrally. The relationship of contingent negative variation, motor potentials and the observed electrocortical patterns is discussed