Etude des paramètres temporels dans un effet consécutif tactilo-kinesthésique

Summary : Temporal factors in a tactile-kinesthetic aftereffect. The aim of this work is to study the effect of two temporal factors (inspection time and time after inspection) on the intensity of a tactile-kinesthetic aftereffect. The subjects' task was to compare two equal weights presented simultaneously to both hands by means of a Piéron's gravimeter (test stimulus). The inspection stimulus consisted of a single presentation, during a controlled time, of two unequal weights preceding the test stimulus. The results obtained show that the intensity of the effect increases linearly with increasing inspection times, while it decreases with increasing times after inspection : this effect desappears after a period of about 20 seconds. These results are consistent with those obtained in previous works. They are interpreted here within the sensory-tonic field theory of Wapner and Werner. Key-words : Kinesthetic aftereffect.Résumé L'objet de ce travail est l'élude de l'influence de deux paramètres temporels, durée de la période d'induction (expérience I) et durée de Vintervalle temporel séparant l'induction du test (expérience II), sur l'intensité d'un effet consécutif tactilo-kinesthésique. Il apparaît que l'intensité de l'effet varie linéairement en fonction directe de la durée de l'induction et en fonction inverse de l'intervalle temporel séparant l'induction du test, pour s'annuler après un délai de 20 s environ. Ces résultats sont cohérents avec ceux obtenus par d'autres auteurs dans le domaine visuel et kinesthésique. Ils sont interprétés dans le cadre de la théorie sensori-tonique de Wapner et Werner. Mots clefs : effet consécutif kinesthésique.Juan de Mendoza J.-L., Cheikhi M. Etude des paramètres temporels dans un effet consécutif tactilo-kinesthésique. In: L'année psychologique. 1982 vol. 82, n°1. pp. 67-74

Ectopic hepatocyte transplantation cures the pig model of tyrosinemia

AbstractThe effectiveness of cell-based therapies to treat liver failure is limited by the diseased liver environment. Herein we provide preclinical proof-of-concept for the treatment of liver failure through hepatocyte transplantation into lymph nodes in a large-animal model of hereditary tyrosinemia type 1 (HT1), a metabolic liver disease caused by deficiency of fumarylacetoacetate hydrolase (FAH) enzyme. FAH-deficient pigs received autologous hepatocyte transplantation into mesenteric lymph nodes afterex vivotransduction with a lentiviral vector carrying the pigFahgene. Hepatocytes showed early (6 hour) and durable (8 month) engraftment in lymph nodes, with reproduction of vascular and hepatic microarchitecture. Subsequently, hepatocytes migrated to and repopulated the native diseased liver. The corrected cells generated enough liver mass to clinically ameliorate disease as early as 97 days post-transplantation, with complete normalization of tyrosine levels and liver function tests. Integration site analysis defined the corrected hepatocytes in the liver as a subpopulation of hepatocytes in the lymph nodes, indicating that the lymph nodes served as a source for healthy hepatocytes to repopulate a diseased liver. Ectopic transplantation of hepatocytes cures the pig model of HT1 and presents a promising approach to the treatment of liver disease in patients with pre-existing liver damage and fibrosis.One Sentence SummaryTransplantation of corrected hepatocytes in mesenteric lymph nodes can cure fatal metabolic liver disease by providing organized liver tissue and by repopulating the diseased liver in the pig tyrosinemia model.</jats:sec