Taking a “Deep Dive”: What Only a Top Leader Can Do

Unlike most historical accounts of strategic change inside large firms, empirical research on strategic management rarely uses the day-to-day behaviors of top executives as the unit of analysis. By examining the resource allocation process closely, we introduce the concept of a deep dive, an intervention when top management seizes hold of the substantive content of a strategic initiative and its operational implementation at the project level, as a way to drive new behaviors that enable an organization to shift its performance trajectory into new dimensions unreachable with any of the previously described forms of intervention. We illustrate the power of this previously underexplored change mechanism with a case study, in which a well-established firm overcame barriers to change that were manifest in a wide range of organizational routines and behavioral norms that had been fostered by the pre-existing structural context of the firm.Strategic Change, Resource Allocation Process, Top-down Intervention

Gamma-ray emission from dark matter wakes of recoiled black holes

A new scenario for the emission of high-energy gamma-rays from dark matter annihilation around massive black holes is presented. A black hole can leave its parent halo, by means of gravitational radiation recoil, in a merger event or in the asymmetric collapse of its progenitor star. A recoiled black hole which moves on an almost-radial orbit outside the virial radius of its central halo, in the cold dark matter background, reaches its apapsis in a finite time. Near or at the apapsis passage, a high-density wake extending over a large radius of influence, forms around the black hole. It is shown that significant gamma-ray emission can result from the enhancement of neutralino annihilation in these wakes. At its apapsis passage, a black hole is shown to produce a flash of high-energy gamma-rays whose duration is determined by the mass of the black hole and the redshift at which it is ejected. The ensemble of such black holes in the Hubble volume is shown to produce a diffuse high-energy gamma-ray background whose magnitude is compared to the diffuse emission from dark matter haloes alone.Comment: version to appear in Astrophysical Journal letters (labels on Fig. 3 corrected

Detection of Evolved High-Redshift Galaxies in Deep NICMOS/VLT Images

A substantial population of high redshift early-type galaxies is detected in very deep UBVRIJHK images towards the HDF-South. Four elliptical profile galaxies are identified in the redshift range z=1-2, all with very red SEDs, implying ages of >2 Gyrs for standard passive evolution. We also find later type IR-luminous galaxies at similarly high redshift, (10 objects with z>1, H1 Gyr. The number and luminosity-densities of these galaxies are comparable with the local E/SO-Sbc populations for \Omega_m>0.2, and in the absence of a significant cosmological constant, we infer that the major fraction of luminous Hubble-sequence galaxies have evolved little since z~2. A highly complete photometric redshift distribution is constructed to H=25 (69 galaxies) showing a broad spread of redshift, peaking at z~1.5, in reasonable agreement with some analyses of the HDF. Five `dropout' galaxies are detected at z~3.8, which are compact in the IR, ~0.5 kpc/h at rest 3500\AA. No example of a blue IR luminous elliptical is found, restricting the star-formation epoch of ellipticals to z>10 for a standard IMF and modest extinction.Comment: 7 pages, 3 figures, accepted for publication in Astrophysical Journal Letters, discussion of clustering added, color image available at http://astro.berkeley.edu/~tjb/nic3.htm

HER2/HER3 regulates lactate secretion and expression of lactate receptor mRNA through the MAP3K4 associated protein GIT1

One of the major features of cancer is Otto Warburg's observation that many tumors have increased extracellular acidification compared to healthy tissues. Since Warburg's observation, the importance of extracellular acidification in cancer is now considered a hallmark of cancer. Human MAP3K4 functions upstream of the p38 and JNK mitogen activated protein kinases (MAPKs). Additionally, MAP3K4 is required for cell migration and extracellular acidification of breast cancer cells in response to HER2/HER3 signaling. Here, we demonstrate that GIT1 interacts with MAP3K4 by immunoprecipitation, while cellular lactate production and the capacity of MCF-7 cells for anchorage independent growth in soft agar were dependent on GIT1. Additionally, we show that activation of HER2/HER3 signaling leads to reduced expression of lactate receptor (GPR81) mRNA and that both, GIT1 and MAP3K4, are necessary for constitutive expression of GPR81 mRNA. Our study suggests that targeting downstream proteins in the HER2/HER3-induced extracellular lactate signaling pathway may be a way to inhibit the Warburg Effect to disrupt tumor growth.NIEHS Training grant [ES007091]; Arizona Science Foundation [CAA 0226-08, ES006694, ES012007, ES04940]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Inappropriate Antidiuresis: Examples of an Hyponatremic Syndrome Resembling Exogenous Vasopressin Administration in Man

We have reviewed some of the features of hyponatremic syndromes, unassociated with sodium retention and edema, but associated with primary water retention. The syndromes were probably caused by excessive vasopressin activity, in the presence of normal circulatory, renal and adreno-cortical function. Underlying diseases, including bronchogenic carcinoma, head injury, and tuberculous meningitis, illustrated the diverse etiologic bases of this condition

HST STIS spectroscopy of the triple nucleus of M31: two nested disks in Keplerian rotation around a Supermassive Black Hole

We present HST spectroscopy of the nucleus of M31 obtained with STIS. Spectra taken around the CaT lines at 8500 see only the red giants in the double bright- ness peaks P1 and P2. In contrast, spectra taken at 3600-5100 A are sensitive to the tiny blue nucleus embedded in P2, the lower surface brightness red nucleus. P2 has a K-type spectrum, but the embedded blue nucleus has an A-type spectrum with strong Balmer absorption lines. Given the small likelihood for stellar collisions, a 200 Myr old starburst appears to be the most plausible origin of the blue nucleus. In stellar population, size, and velocity dispersion, the blue nucleus is so different from P1 and P2 that we call it P3. The line-of-sight velocity distributions of the red stars in P1+P2 strengthen the support for Tremaine s eccentric disk model. The kinematics of P3 is consistent with a circular stellar disk in Keplerian rotation around a super-massive black hole with M_bh = 1.4 x 10^8 M_sun. The P3 and the P1+P2 disks rotate in the same sense and are almost coplanar. The observed velocity dispersion of P3 is due to blurred rotation and has a maximum value of sigma = 1183+-201 km/s. The observed peak rotation velocity of P3 is V = 618+-81 km/s at radius 0.05" = 0.19 pc corresponding to a circular rotation velocity at this radius of ~1700 km/s. Any dark star cluster alternative to a black hole must have a half-mass radius <= 0.03" = 0.11 pc. We show that this excludes clusters of brown dwarfs or dead stars on astrophysical grounds.Comment: Astrophysical Journal, Sep 20, 2005, 21 pages including 20 figure

Probing the evolution of early-type cluster galaxies through chemical enrichment

A simple chemical enrichment model for cluster early-type galaxies is described in which the mechanisms considered in the evolutionary model are infall of primordial gas, outflows and a possible variation in the star formation efficiency. We find that - within the framework of our models - only outflows can generate a suitable range of metallicities. The chemical enrichment tracks can be combined with the latest population synthesis models to simulate clusters over a wide redshift range, for a set of toy models. The color-magnitude relation of local clusters is used as a constraint, fixing the correlation between absolute luminosity and ejected fraction of gas from outflows. It is found that the correlations between color or mass-to-light ratios and absolute luminosity are degenerate with respect to most of the input parameters. However, a significant change between monolithic and hierarchical models is predicted for redshifts z\simgt 1. The comparison between predicted and observed mass-to-light ratios yield an approximate linear bias between total and stellar masses: $M_{\rm Tot}\propto M_{\rm St}^{1.15\pm 0.08}$ in early-type galaxies. If we assume that outflows constitute the driving mechanism for the colors observed in cluster early type galaxies, the metallicity of the intracluster medium (ICM) can be linked to outflows. The color-magnitude constraint requires faint $M_V\sim -16$ galaxies to eject 85% of their gas, which means that most of the metals in the ICM may have originated in these dwarf galaxies.Comment: Accepted for publication in ApJ. Uses emulateapj.sty. 12 pages with 10 embedded EPS figure

Feedback Processes in Early-Type Galaxies

We present a phenomenological model of feedback in early-type galaxies that tracks the evolution of the interstellar medium gas mass, metallicity, and temperature. Modeling the star formation rate as a Schmidt law with a temperature-dependent efficiency, we find that intermittent episodes of star formation are common in moderate-size ellipticals. Our model is applicable in the case in which the thermalization time from SN is sufficiently long that spatial variations are relatively unimportant, an appropriate assumption for the empirical parameters adopted here. The departure from a standard scenario of passive evolution implies significantly younger luminosity-weighted ages for the stellar populations of low-mass galaxies at moderate redshifts, even though the more physically meaningful mass-weighted ages are changed only slightly. Secondary bursts of star formation also lead to a natural explanation of the large scatter in the NUV-optical relation observed in clusters at moderate redshift and account for the population of E+A galaxies that display a spheroidal morphology. As the late-time formation of stars in our model is due to the gradual cooling of the interstellar medium, which is heated to temperatures ~1 keV by the initial burst of supernovae, our conclusions do not rely on any environmental effects or external mechanisms. Furthermore, a simple estimate of the X-ray emission from this supernova heated gas leads to an L_X vs L_B correlation that is in good agreement with observed values. Thus feedback processes may be essential to understanding the observed properties of early-type galaxies from the optical to the X-ray.Comment: Accepted for publication in ApJ. Uses emulateapj.sty. 12 pages with 8 embedded EPS figure

First Results from a Photometric Survey of Strong Gravitational Lens Environments

Many strong gravitational lenses lie in complex environments, such as poor groups of galaxies, that significantly bias conclusions from lens analyses. We are undertaking a photometric survey of all known galaxy-mass strong lenses to characterize their environments and include them in careful lens modeling, and to build a large, uniform sample of galaxy groups at intermediate redshifts for evolutionary studies. In this paper we present wide-field photometry of the environments of twelve lens systems with 0.24 < z_lens < 0.5. Using a red-sequence identifying technique, we find that eight of the twelve lenses lie in groups, and that ten group-like structures are projected along the line of sight towards seven of these lenses. Follow-up spectroscopy of a subset of these fields confirms these results. For lenses in groups, the group centroid position is consistent with the direction of the external tidal shear required by lens models. Lens galaxies are not all super-L_* ellipticals; the median lens luminosity is < L_*, and the distribution of lens luminosities extends 3 magnitudes below L_* (in agreement with theoretical models). Only two of the lenses in groups are the brightest group galaxy, in qualitative agreement with theoretical predictions. As in the local Universe, the highest velocity-dispersion groups contain a brightest member spatially coincident with the group centroid, whereas lower-dispersion groups tend to have an offset brightest group galaxy. This suggests that higher-dispersion groups are more dynamically relaxed than lower-dispersion groups and that at least some evolved groups exist by z ~ 0.5.Comment: Accepted for publication to the Astrophysical Journal. Figure 1 reduced in resolution. Requires emulateapj.sty. Table 6 to be published electronically. Revised version includes moderate changes to text, minor changes to conclusions, addition of one subsectio

Observations and Theoretical Implications of the Large Separation Lensed Quasar SDSS J1004+4112

We study the recently discovered gravitational lens SDSS J1004+4112, the first quasar lensed by a cluster of galaxies. It consists of four images with a maximum separation of 14.62''. The system has been confirmed as a lensed quasar at z=1.734 on the basis of deep imaging and spectroscopic follow-up observations. We present color-magnitude relations for galaxies near the lens plus spectroscopy of three central cluster members, which unambiguously confirm that a cluster at z=0.68 is responsible for the large image separation. We find a wide range of lens models consistent with the data, but they suggest four general conclusions: (1) the brightest cluster galaxy and the center of the cluster potential well appear to be offset by several kpc; (2) the cluster mass distribution must be elongated in the North--South direction, which is consistent with the observed distribution of cluster galaxies; (3) the inference of a large tidal shear (~0.2) suggests significant substructure in the cluster; and (4) enormous uncertainty in the predicted time delays between the images means that measuring the delays would greatly improve constraints on the models. We also compute the probability of such large separation lensing in the SDSS quasar sample, on the basis of the CDM model. The lack of large separation lenses in previous surveys and the discovery of one in SDSS together imply a mass fluctuation normalization \sigma_8=1.0^{+0.4}_{-0.2} (95% CL), if cluster dark matter halos have an inner slope -1.5. Shallower profiles would require higher values of \sigma_8. Although the statistical conclusion might be somewhat dependent on the degree of the complexity of the lens potential, the discovery is consistent with the predictions of the abundance of cluster-scale halos in the CDM scenario. (Abridged)Comment: 21 pages, 24 figures, 5 tables, accepted for publication in Ap