33 research outputs found
Varicose Remodeling of Veins Is Suppressed by 3âHydroxyâ3âMethylglutaryl Coenzyme A Reductase Inhibitors
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Vitamin D binding protein is not affected by high-dose vitamin D supplementation: a post hoc analysis of a randomised, placebo-controlled study
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Do educational meetings and group detailing change adherence to drug formularies in hospitals? A cluster randomized controlled trial
No full textDrugs commonly associated with weight change: umbrella systematic review and meta-analysis (Protocol)
No full textA novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells*
No full textHuman thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on human leukemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlichâs ascites carcinoma-bearing mice were used to investigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors
