Angular momentum transport and element mixing in the stellar interior I. Application to the rotating Sun

The purpose of this work was to obtain diffusion coefficient for the magnetic angular momentum transport and material transport in a rotating solar model. We assumed that the transport of both angular momentum and chemical elements caused by magnetic fields could be treated as a diffusion process. The diffusion coefficient depends on the stellar radius, angular velocity, and the configuration of magnetic fields. By using of this coefficient, it is found that our model becomes more consistent with the helioseismic results of total angular momentum, angular momentum density, and the rotation rate in a radiative region than the one without magnetic fields. Not only can the magnetic fields redistribute angular momentum efficiently, but they can also strengthen the coupling between the radiative and convective zones. As a result, the sharp gradient of the rotation rate is reduced at the bottom of the convective zone. The thickness of the layer of sharp radial change in the rotation rate is about 0.036 $R_{\odot}$ in our model. Furthermore, the difference of the sound-speed square between the seismic Sun and the model is improved by mixing the material that is associated with angular momentum transport.Comment: 8 pages, 2 figure

Structural and Functional Aspects of Class A Carbapenemases.

The fight against infectious diseases is probably one of the greatest public health challenges faced by our society, especially with the emergence of carbapenem-resistant gram-negatives that are in some cases pan-drug resistant. Currently,β-lactamase-mediated resistance does not spare even the newest and most powerful β-lactams (carbapenems), whose activity is challenged by carbapenemases. The worldwide dissemination of carbapenemases in gram-negative organisms threatens to take medicine back into the pre-antibiotic era since the mortality associated with infections caused by these superbugs is very high, due to limited treatment options. Clinically-relevant carbapenemases belong either to metallo-β- lactamases (MBLs) of Ambler class B or to serine-β-lactamases (SBLs) of Ambler class A and D enzymes. Class A carbapenemases may be chromosomally-encoded (SME, NmcA, SFC-1, BIC-1, PenA, FPH-1, SHV-38), plasmid-encoded (KPC, GES, FRI-1) or both (IMI). The plasmid-encoded enzymes are often associated with mobile elements responsible for their mobilization. These enzymes, even though weakly related in terms of sequence identities, share structural features and a common mechanism of action. They variably hydrolyse penicillins, cephalosporins, monobactams, carbapenems, and are inhibited by clavulanate and tazobactam. Three-dimensional structures of class A carbapenemases, in the apo form or in complex with substrates/inhibitors, together with site-directed mutagenesis studies, provide essential input for identifying the structural factors and subtle conformational changes that influence the hydrolytic profile and inhibition of these enzymes. Overall, these data represent the building blocks for understanding the structure-function relationships that define the phenotypes of class A carbapenemases and can guide the design of new molecules of therapeutic interest

Seismic analysis of 70 Ophiuchi A: A new quantity proposed

The basic intent of this paper is to model 70 Ophiuchi A using the latest asteroseismic observations as complementary constraints and to determine the fundamental parameters of the star. Additionally, we propose a new quantity to lift the degeneracy between the initial chemical composition and stellar age. Using the Yale stellar evolution code (YREC7), we construct a series of stellar evolutionary tracks for the mass range $M$ = 0.85 -- 0.93 $M_{\odot}$ with different composition $Y_{i}$ (0.26 -- 0.30) and $Z_{i}$ (0.017 -- 0.023). Along these tracks, we select a grid of stellar model candidates that fall within the error box in the HR diagram to calculate the theoretical frequencies, the large- and small- frequency separations using the Guenther's stellar pulsation code. Following the asymptotic formula of stellar $p$-modes, we define a quantity $r_{01}$ which is correlated with stellar age. Also, we test it by theoretical adiabatic frequencies of many models. Many detailed models of 70 Ophiuchi A have been listed in Table 3. By combining all non-asteroseismic observations available for 70 Ophiuchi A with these seismological data, we think that Model 60, Model 125 and Model 126, listed in Table 3, are the optimum models presently. Meanwhile, we predict that the radius of this star is about 0.860 -- 0.865 $R_{\odot}$ and the age is about 6.8 -- 7.0 Gyr with mass 0.89 -- 0.90 $M_{\odot}$. Additionally, we prove that the new quantity $r_{01}$ can be a useful indicator of stellar age.Comment: 23 pages, 5 figures, accepted by New Astronom

Solar Models with Revised Abundances and Opacities

Using reconstructed opacities, we construct solar models with low heavy-element abundance. Rotational mixing and enhanced diffusion of helium and heavy elements are used to reconcile the recently observed abundances with helioseismology. The sound speed and density of models where the relative and absolute diffusion coefficients for helium and heavy elements have been increased agree with seismically inferred values at better than the 0.005 and 0.02 fractional level respectively. However, the surface helium abundance of the enhanced diffusion model is too low. The low helium problem in the enhanced diffusion model can be solved to a great extent by rotational mixing. The surface helium and the convection zone depth of rotating model M04R3, which has a surface Z of 0.0154, agree with the seismic results at the levels of 1 $\sigma$ and 3 $\sigma$ respectively. M04R3 is almost as good as the standard model M98. Some discrepancies between the models constructed in accord with the new element abundances and seismic constraints can be solved individually, but it seems difficult to resolve them as a whole scenario.Comment: 10 pages, 1 figur

Facile and green fabrication of multiple magnetite nano-cores@void@porous shell microspheres for delivery vehicles

Multiple magnetite nano-cores@void@porous shell micro-spheres have been fabricated by using the algae cell wall as the hollow porous shell precursor and the intracellular substances as the reducing agents to form magnetite cores inside the microspheres via hydrothermal reactions. This method not only simplified the fabricating steps and superseded harmful chemical reagents, but also endow the microspheres with a uniform size (~2.5 um), porous shell (~15 nm), multiple magnetite nano-cores (~25 nm) and high void volume ratio (> 70%). The product presents fast magnetic separation and redispersibility as well as pH-switched protein auto-loading (high capacity > 600 mg g-1) and unloading as high performance deliver vehicles

Asteroseismic study of solar-like stars: A method of estimating stellar age

Asteroseismology, as a tool to use the indirect information contained in stellar oscillations to probe the stellar interiors, is an active field of research presently. Stellar age, as a fundamental property of star apart from its mass, is most difficult to estimate. In addition, the estimating of stellar age can provide the chance to study the time evolution of astronomical phenomena. In our poster, we summarize our previous work and further present a method to determine age of low-mass main-sequence star.Comment: 2 pages, 1 figures, submitted to IAUS25

Synthesis of Positron Emission Tomography (PET) Images via Multi-channel Generative Adversarial Networks (GANs)

Positron emission tomography (PET) image synthesis plays an important role, which can be used to boost the training data for computer aided diagnosis systems. However, existing image synthesis methods have problems in synthesizing the low resolution PET images. To address these limitations, we propose multi-channel generative adversarial networks (M-GAN) based PET image synthesis method. Different to the existing methods which rely on using low-level features, the proposed M-GAN is capable to represent the features in a high-level of semantic based on the adversarial learning concept. In addition, M-GAN enables to take the input from the annotation (label) to synthesize the high uptake regions e.g., tumors and from the computed tomography (CT) images to constrain the appearance consistency and output the synthetic PET images directly. Our results on 50 lung cancer PET-CT studies indicate that our method was much closer to the real PET images when compared with the existing methods.Comment: 9 pages, 2 figure

Small‐for‐size liver transplanted into larger recipient: A model of hepatic regeneration

Orthotopic liver transplantation was performed in 60 recipient rats weighing 200 to 250 gm. Sixty rats of the same strain were used as liver donors, 30 weighing 100 to 140 gm (small for size) and the other 30 weighing 200 to 250 gm (same size). After 1, 2, 3, 4, 7 and 14 days (n = 5 each) DNA synthesis, nuclear thymidine labeling and mitoses were increased in both the small‐for‐size and same‐size groups, but significantly more in the former. These changes were maximal after 48 to 72 hr, similar to but later than the well‐known regeneration response after partial hepatectomy, which peaks at 24 hr in rats. Indirect indexes of regeneration of the transplanted livers also were measured: plasma or serum ornithine decarboxylase; insulin and glucagon serum levels; estradiol and testosterone serum levels (and their nuclear and cytosolic receptors); and transforming growth factor‐ß, c‐Ha‐ras and c‐jun mRNA expressions. With the small‐for‐size transplantation, these followed the same delayed pattern as the direct regeneration parameters. The small livers gradually increased in size over the course of 1 to 2 wk and achieved a volume equal to that of the liver originally present in the recipient. In contrast, no significant liver weight gain occurred in the transplanted livers from same‐size donors despite the evidence of regeneration by direct indexes, but not by most of the surrogate parameters, including ornithine decarboxylase. (Hepatology 1993;19:210–216). Copyright © 1994 American Association for the Study of Liver Disease

Assessing plantar sensation in the foot using the FOot Roughness Discrimination Test (FoRDT™): a reliability and validity study in stroke

BACKGROUND: The foot sole represents a sensory dynamometric map and is essential for balance and gait control. Sensory impairments are common, yet often difficult to quantify in neurological conditions, particularly stroke. A functionally oriented and quantifiable assessment, the Foot Roughness Discrimination Test (FoRDT™), was developed to address these shortcomings. OBJECTIVE: To evaluate inter- and intra-rater reliability, convergent and discriminant validity of the Foot Roughness Discrimination Test (FoRDT™). DESIGN: Test-retest design. SETTING: Hospital Outpatient. PARTICIPANTS: Thirty-two people with stroke (mean age 70) at least 3 months after stroke, and 32 healthy, age-matched controls (mean age 70). MAIN OUTCOME MEASURES: Roughness discrimination thresholds were quantified utilising acrylic foot plates, laser-cut to produce graded spatial gratings. Stroke participants were tested on three occasions, and by two different raters. Inter- and intra-rater reliability and agreement were evaluated with Intraclass Correlation Coefficients and Bland-Altman plots. Convergent validity was evaluated through Spearman rank correlation coefficients (rho) between the FoRDT™ and the Erasmus modified Nottingham Sensory Assessment (EmNSA). RESULTS: Intra- and inter rater reliability and agreement were excellent (ICC =.86 (95% CI .72-.92) and .90 (95% CI .76 -.96)). Discriminant validity was demonstrated through significant differences in FoRDT™ between stroke and control participants (p.05). CONCLUSIONS: This simple and functionally oriented test of plantar sensation is reliable, valid and clinically feasible for use in an ambulatory, chronic stroke and elderly population. It offers clinicians and researchers a sensitive and robust sensory measure and may further support the evaluation of rehabilitation targeting foot sensation. This article is protected by copyright. All rights reserved