58 research outputs found
ChemInform Abstract: Quantitation and Sequence Dependence of Racemization in Peptide Synthesis
Full text linkPeptide-Cleavable Self-immolative Maytansinoid AntibodyDrug Conjugates Designed To Provide Improved Bystander Killing
No full textTHE METABOLISM OF γ-HYDROXYGLUTAMIC-α-C<sup>14</sup> ACID IN THE INTACT RAT
Full text link Synthetic γ-hydroxyglutamic-α-C14 acid was found to be extensively catabolized in the intact rat and to give rise to both labelled glutamic and aspartic acids. The results obtained are in agreement with a previously proposed theory that γ-hydroxyglutamic acid may be converted to glutamic and aspartic acids by two distinct metabolic routes. The fact that only a small amount of radiocarbon was found in the tissue hydroxyproline suggests that the conversion of γ-hydroxyglutamic acid to hydroxyproline, if it does occur, is of minor importance. </jats:p
THE METABOLISM OF γ-HYDROXYGLUTAMIC-α-C<sup>14</sup> ACID IN THE INTACT RAT
Full text link Synthetic γ-hydroxyglutamic-α-C14 acid was found to be extensively catabolized in the intact rat and to give rise to both labelled glutamic and aspartic acids. The results obtained are in agreement with a previously proposed theory that γ-hydroxyglutamic acid may be converted to glutamic and aspartic acids by two distinct metabolic routes. The fact that only a small amount of radiocarbon was found in the tissue hydroxyproline suggests that the conversion of γ-hydroxyglutamic acid to hydroxyproline, if it does occur, is of minor importance. </jats:p
ChemInform Abstract: N-METHYLAMINO ACIDS IN PEPTIDE SYNTHESIS. V. THE SYNTHESIS OF N-TERT-BUTYLOXYCARBONYL, N-METHYLAMINO ACIDS BY N-METHYLATION
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ChemInform Abstract: REACTION OF N-TERT-BUTOXYCARBONYLAMINO ACID ANHYDRIDES WITH TERTIARY AMINES AND CARBODIIMIDES. NEW PRECURSORS FOR 2-TERT-BUTOXYOXAZOL-5(4H)-ONE AND N-ACYLUREAS
Full text linkChemInform Abstract: N-ETHYLAMINO ACID SYNTHESIS AND N-ACYLAMINO ACID CLEAVAGE USING MEERWEIN′S REAGENT
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ChemInform Abstract: 2-ALKOXY-5(4H)-OXAZOLONES FROM N-ALKOXYCARBONYLAMINO ACIDS AND THEIR IMPLICATION IN CARBODIIMIDE-MEDIATED REACTIONS IN PEPTIDE SYNTHESIS
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