Gingival hyperplasia as an early manifestation of acute myeloid leukemia. A retrospective review

We study the prevalence of acute myeloid leukemia (AML) among patients with severe gingival enlargement. We retrospective reviewed the clinical records of patients with severe gingival enlargement, between 2011 and 2018. The Saxer and Mühlemann index were used to measure inflammation and gingival bleeding. The degree of dental mobility was measured by the Nyman and Lindhe technique. A correlation analysis was carried out to test whether there were any associations among the different variables. In the sample of 117 patients the mean gingival bleeding index was ?3 and the degree of dental mobility ?2.3. 1.7% of patients, with severe gingival hyperplasia were diagnosed with AML. We found a significant association between gingival bleeding and aging (p<0.001) and a trend (0.54) between bleeding and suffering from AML. Severe gingival enlargement, abundant gingival bleeding, and dental mobility could be early manifestations of a blood dyscrasia

Towards a global model of the martian atmosphere

In an effort to continuously improve the capabilities of the Martian atmospheric predictions at LMD, the GCM has been extended into thermospheric heights thus creating the first model to self-consistently couple the lower and upper regions of the Martian atmosphere. The behaviour of the Martian thermosphere is strongly influenced by lower atmospheric processes and has complex dynamics. Such a fully coupled model will certainly aid in the preparation of future missions and on the analysis of future high altitude data, as well as serve as a base for the simulation of ionospheric processes, escape, etc

The collapse of Io's primary atmosphere in Jupiter eclipse

Volcanic outgassing due to tidal heating is the ultimate source of a tenuous SO atmosphere around Jupiter's moon Io. The question of whether SO frost on the surface plays a part, and to what degree, in maintaining Io's atmosphere with the constant volcanic outgassing is still debated. It is believed that for a sublimation-supported atmosphere, the primary atmosphere should collapse during eclipses by Jupiter, as the SO vapor pressure is strongly coupled to the temperature of the ice on the surface. No direct observations of Io's atmosphere in eclipse have previously been possible, due to the simultaneous need for high spectral and time sensitivity, as well as a high signal-to-noise ratio. Here we present the first ever high-resolution spectra at 19 µm of Io's SO atmosphere in Jupiter eclipse from the Gemini telescope. The strongest atmospheric band depth is seen to dramatically decay from 2.5 ± (0.08)% before the eclipse to 0.18 ± (0.16)% after 40 min in eclipse. Further modeling indicates that the atmosphere has collapsed shortly after eclipse ingress, implying that the atmosphere of Io has a strong sublimation-controlled component. The atmospheric column density—from pre-eclipse to in-eclipse—drops by a factor of 5 ± 2.C.C.C.T. and J.R.S. at Southwest Research Institute were funded by NASA Outer Planets Research grant NNX14AC63G and Planetary Astronomy grant NNX11AD61G. M.A.L.V. was funded by the Spanish Ministerio de Economia y Competitividad and by FEDER funds under project ESP2015-65064-C2-1-P (MINECO/FEDER)Peer Reviewe

Influencia de la administración de parathormona, calcitonina y tiroxina sobre la excreción de calcio endógeno

The influence of seyeral hormonal factors on calcium, endogenous excretion was studied in adult rats. The injection of parathyroid hormone doesn't change the fecal endogenous calcium. It may be that the parathyroid hormone have a real effect over the intestinal absortion of calcium, effect, that in our experiments, would be masked by an increase in the calcitonine secretion. In the kidney, the parathyroid hormone causes an increase, of endogenous caldum excretion highly significative, which it would be possible the result of the raising of the calcemia. The administration of calcitonine or thyroxine produces an increase in the fecal and urinary excretion of endogenous calcium. Possibly, the calcitonine produces hypercalciurie and hypocalcemia acting directly upon the kidney and inhibiting the tubular reabsorption of calcium.Se estudia la influencia de varios factores hormonales sobre la excreción de calcio endógeno en ratas adultas de la cepa Nestlé. En nuestras condiciones experimentales la administración de parathormona no cambia la excreción fecal de calcio endógeno. Puede ser que la parathormona tenga un efecto real sobre la absorción intestinal de calcio, efecto que en nuestro caso quedaría enmascarado por un aumento en la secreción de calcitonina. A nivel renal la administración de parathormona produce un incremento estadísticamente significativo de la excreción de calcio endógeno, que podría ser el resultado de la elevación de la calcemia. La administración de calcitonina o de tiroxina dan lugar a un incremento en la excreción fecal y urinaria de calcio endógeno. Posiblemente la calcitonina produzca hipercalciuria e hipocalcemia actuando directamente a nivel renal e inhibiendo la reabsorción tubular de calcio

Oral pathology in the Iberian Neanderthals

In 1994, a series of human bones was found at the Sidrón cave in Borines (Concejo de Piloña, Asturias), Spain. Since the investigators suspected that they were dealing with human remains from the Spanish Civil War (1936-1939), the bones were collected by the Civil Guard, but were not subjected to archeological scrutiny. The finding was reported then to the corresponding authorities, who had them sent to the Laboratory of Forensic Anthropology of the Forensic Institute of Madrid (Spain), where an anthropological study was undertaken. This revealed the extraordinary palaeoanthropological and palaeopathological interest of the remains. The specimen studied herein, a mandible catalogued as SDR 7-8 (SIDRON 7-8) by the Forensic Laboratory in Madrid (Spain) and belonging to Homo neanderthalensis, with an age of 90,000 to 40,000 years BCE, showed special characteristics of oral pathology, making it a specimen of great palaeodontological interest.Key words: Mandible, Neanderthal, oral pathology, Sidrón, Asturias

Safety and Efficacy of a New Synthetic Material Based on Monetite, Silica Gel, PS-Wallastonite, and a Hydroxyapatite Calcium Deficient: A Randomized Comparative Clinic Trial

Background and Objectives: Maxillary bone defects related to post-extraction alveolar ridge resorption are usual. These defects may lead to failure in further surgical implant phases given the lack of bone volume to perform the dental implant. The objective of this clinical assay was to evaluate the safety and efficacy of an experimental synthetic bone substitute in the preservation of post-extraction maxillary alveoli. Materials and Methods: 33 voluntary patients who had at least one maxillary premolar tooth that was a candidate for exodontia (n = 39) and subsequent implant rehabilitation participated. The regenerated alveoli were monitored by means of periodic clinical examinations (days 9 ± 1, 21 ± 4, 42 ± 6, and 84 ± 6), measuring the height and width of the alveolar crest (days 0 and 180 ± 5), measurement of radiodensity using tomographic techniques (days 0–5 and 175 ± 5), and histological examination of biopsies collected at 180 ± 5 days. Results: No significant differences were observed during the entire follow-up period between the two groups with respect to the safety variables studied. A variation in width of −0.9 ± 1.3 mm and −0.6 ± 1.5 mm, and a variation in height of −0.1 ± 0.9 mm and −0.3 ± 0.7 mm was observed for experimental material Sil-Oss® and Bio-Oss®, respectively. The radiodensity of the alveoli regenerated with the experimental material was significantly lower than that corresponding to Bio-Oss®. However, the histological study showed greater osteoid matrix and replacement of the material with newformed bone in the implanted beds with the experimental material. Conclusions: Both materials can be used safely and proved equally effective in maintaining alveolar flange dimensions, they are also histologically biocompatible, bioactive and osteoconductive. The experimental material showed the advantage of being resorbable and replaced with newformed bone, in addition to promoting bone regeneration

Variability of the Martian thermosphere during eight Martian years as simulated by a ground-to-exosphere global circulation model

Using a ground-to-exosphere general circulation model for Mars we have simulated the variability of the dayside temperatures at the exobase during eight Martian years (MY, from MY24 to MY31, approximately from 1998 to 2013), taking into account the observed day-to-day solar and dust load variability. We show that the simulated temperatures are in good agreement with the exospheric temperatures derived from Precise Orbit Determination of Mars Global Surveyor. We then study the effects of the solar variability and of two planetary-encircling dust storms on the simulated temperatures. The seasonal effect produced by the large eccentricity of the Martian orbit translates in an aphelion-to-perihelion temperature contrast in every simulated year. However, the magnitude of this seasonal temperature variation is strongly affected by the solar conditions, ranging from 50 K for years corresponding to solar minimum conditions to almost 140 K during the last solar maximum. The 27 day solar rotation cycle is observed on the simulated temperatures at the exobase, with average amplitude of the temperature oscillation of 2.6 K but with a significant interannual variability. These two results highlight the importance of taking into account the solar variability when simulating the Martian upper atmosphere and likely have important implications concerning the atmospheric escape rate. We also show that the global dust storms in MY25 and MY28 have a significant effect on the simulated temperatures. In general, they increase the exospheric temperatures over the low latitude and midlatitude regions and decrease them in the polar regions.©2015. American Geophysical Union. All Rights Reserved.F.G.G. was partly funded by a CSIC JAE-Doc grant financed by the European Social Fund. F.G.G., M.-A.L.V., and M.G.C. thank the Spanish MICINN for funding support through the CONSOLIDER program ASTROMOLCSD2009-00038 and through projects AYA2011-23552/ESP and AYA2012-39691-C02-01. This work has also been partially funded by the ESA-CNES project Mars Climate Database and Physical Models.Peer Reviewe

The new Mars climate database

Not available

IAA : Información y actualidad astronómica (10)

Sumario : Investigación: Chorros relativistas en núcleos activos de galaxias.-- Materia oscura: a tientas por el Universo.-- Ventana Abierta: Físico teórico autónomo se ofrece para.-- Charlas con… Robert Haberle.-- Actualidad Científica: La búsqueda de las estrellas más viejas de la Galaxia.-- Un superbólido más brillante que la Luna llena surcó el cielo argelino.-- Actividades IAA.-- Agenda.Esta revista se publica con la ayuda de la Acción Especial DIF 2001-4284-E del Programa Nacional de Difusión de la Ciencia y la Tecnología, del Ministerio de Ciencia y TecnologíaN

Spontaneous reporting of adverse drug reactions in a pediatric population in a tertiary hospital

The pediatric population is a vulnerable group for adverse drug reactions (ADRs), and data on spontaneous reporting of ADRs in the hospital setting are scarce. We conducted a retrospective analysis of ADRs in pediatric patients spontaneously reported by health care professionals to a Pharmacovigilance Program in a tertiary hospital between 2010 and 2020, and we compared characteristics of ADRs between pediatric age subgroups. From 1787 spontaneously reported ADRs in an 11-year period, 103 (5.85%) were pediatric ADRs. The median age of patients with ADRs was 8.4 years (range 1 day-17 years) and 57.3% were male. The most frequent ADRs reported were nervous system disorders (13.6%) and the most frequently involved drugs were antineoplastics and immunodulators (32.4%). A 59.2% of the ADRs were serious and 55.3% were classified as being type B reactions. Medication errors were involved in 7.8% of the ADRs and 11.9% of the suspected drugs were used off-label. Spontaneous reports of ADRs in newborns, infants, and toddlers were more serious and less often described in the product data sheet than in children and adolescents (p < 0.001 and p = 0.004 respectively). Medication errors were more frequent in patients under two years of age. These results should be interpreted with caution due to under-reporting and biases in spontaneous reporting of ADRs