Enchiridion medicinae, in quo precipua theoricae & practicae iuxta classicoru[m] authorum dogmata dilucidantur, multaque triuialium medicoru[m] nota[n]tur errata

Copia digital. Madrid. Vitoria-Gasteiz : Ministerio de Cultura, Subdirección General de Coordinación Bibliotecaria : Fundación Sancho el Sabio, 2009PergaminoDatos de impresión constan en el colofónSign.: [1-3]8, a-z8, A10, []2Error de encuadernación, hay 2 h. sin signatura entre A5 y A6 (h. CLXXXIX Y CXC)Al final 2 p. manuscrita

Antarctic ozone hole modifies iodine geochemistry on the Antarctic Plateau

Polar stratospheric ozone has decreased since the 1970s due to anthropogenic emissions of chlorofluorocarbons and halons, resulting in the formation of an ozone hole over Antarctica. The effects of the ozone hole and the associated increase in incoming UV-radiation on terrestrial and marine ecosystems are well studied, however the impact on geochemical cycles of ice photoactive elements, such as iodine, remains almost unexplored. Here, we present the first iodine record from the inner Antarctic Plateau (Dome C) that covers approximately the last 212 years (1800-2012 CE). Our results show that iodine concentration in ice remained fairly constant during the pre-ozone hole period (1800-1974 CE) but has declined twofold since the onset of the ozone hole era (~1975 CE), closely tracking the total ozone evolution over Antarctica. Based on ice core observations, laboratory measurements and chemistry-climate model simulations, we propose that the iodine decrease since ~1975 is caused by enhanced iodine re-emission from snowpack due to the ozone hole driven increase in UV-radiation reaching the Antarctic Plateau. These findings suggest the potential for ice core iodine records from the inner Antarctic Plateau as an archive for past stratospheric ozone trends.Fil: Spolaor, Andrea. National Research Council of Italy. Institute of Polar Sciences; Italia. Università Ca’ Foscari di Venezia; ItaliaFil: Burgay, François. Università Ca’ Foscari di Venezia; Italia. Paul Scherrer Institut. Laboratory of Environmental Chemistry; SuizaFil: Fernandez, Rafael Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Turetta, Carla. National Research Council of Italy, Institute of Polar Sciences; Italia. Università Ca’ Foscari di Venezia; ItaliaFil: Cuevas, Carlos A.. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Kim, Kitae. Korea Polar Research Institute; Corea del SurFil: Kinnison, Douglas E.. National Center for Atmospheric Research; Estados UnidosFil: Lamarque, Jean-Francoise. National Center for Atmospheric Research; Estados UnidosFil: de Blasi, Fabrizio. National Research Council of Italy, Institute of Polar Sciences; Italia. Università Ca’ Foscari di Venezia; ItaliaFil: Barbaro, Elena. National Research Council of Italy, Institute of Polar Sciences; Italia. Università Ca’ Foscari di Venezia; ItaliaFil: Corella, Juan Pablo. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Barbante, Carlo. National Research Council of Italy, Institute of Polar Sciences; ItaliaFil: Saiz López, Alfonso. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Vallelonga, Paul. University of Copenhagen, Physics of Ice, Climate and Earth, Niels Bohr Institute; DinamarcaFil: Massimo, Frezzotti. Università Roma Tre III; ItaliaFil: Barbante, Carlo. National Research Council of Italy, Institute of Polar Sciences; Italia. Università Ca’ Foscari di Venezia; ItaliaFil: Saiz López, Alfonso. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaEuropean Geosciences Union General AssemblyVienaAustriaCopernicus Meeting

Antarctic ozone hole modifies iodine geochemistry on the Antarctic Plateau

Polar stratospheric ozone has decreased since the 1970s due to anthropogenic emissions of chlorofluorocarbons and halons, resulting in the formation of an ozone hole over Antarctica. The effects of the ozone hole and the associated increase in incoming UV radiation on terrestrial and marine ecosystems are well established; however, the impact on geochemical cycles of ice photoactive elements, such as iodine, remains mostly unexplored. Here, we present the first iodine record from the inner Antarctic Plateau (Dome C) that covers approximately the last 212 years (1800-2012 CE). Our results show that the iodine concentration in ice remained constant during the pre-ozone hole period (1800-1974 CE) but has declined twofold since the onset of the ozone hole era (~1975 CE), closely tracking the total ozone evolution over Antarctica. Based on ice core observations, laboratory measurements and chemistry-climate model simulations, we propose that the iodine decrease since ~1975 is caused by enhanced iodine re-emission from snowpack due to the ozone hole-driven increase in UV radiation reaching the Antarctic Plateau. These findings suggest the potential for ice core iodine records from the inner Antarctic Plateau to be as an archive for past stratospheric ozone trends.Fil: Spolaor, Andrea. Consiglio Nazionale Delle Ricerche. Istituto Di Scienze Polari.; Italia. Universita' Ca' Foscari Di Venezia; ItaliaFil: Burgay, François. Universita' Ca' Foscari Di Venezia; Italia. Paul Scherrer Institute; SuizaFil: Fernandez, Rafael Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; ArgentinaFil: Turetta, Clara. Consiglio Nazionale Delle Ricerche. Istituto Di Scienze Polari.; Italia. Universita' Ca' Foscari Di Venezia; ItaliaFil: Cuevas, Carlos A.. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Kim, Kitae. Korea Polar Research Institute; Corea del SurFil: Kinnison, Douglas E.. National Center for Atmospheric Research; Estados UnidosFil: Lamarque, Jean-François. National Center for Atmospheric Research; Estados UnidosFil: de Blasi, Fabrizio. Consiglio Nazionale Delle Ricerche. Istituto Di Scienze Polari.; Italia. Universita' Ca' Foscari Di Venezia; ItaliaFil: Barbaro, Elena. Consiglio Nazionale Delle Ricerche. Istituto Di Scienze Polari.; Italia. Universita' Ca' Foscari Di Venezia; ItaliaFil: Corella, Juan Pablo. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Vallelonga, Paul. Universidad de Copenhagen; Dinamarca. University of Western Australia; AustraliaFil: Frezzotti, Massimo. Università Roma Tre Iii. Dipartimento Di Scienze.; ItaliaFil: Barbante, Carlo. Consiglio Nazionale Delle Ricerche. Istituto Di Scienze Polari.; Italia. Universita' Ca' Foscari Di Venezia; ItaliaFil: Saiz López, Alfonso. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; Españ

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Enchiridion medicinae, in quo precipua theoricae & practicae iuxta classicoru[m] authorum dogmata dilucidantur, multaque triuialium medicoru[m] nota[n]tur errata / Alfonso Lupeio Curaeleano.

CCPB, 000015941-7PALAU, 141009Digitalización Vitoria-Gasteiz Fundación Sancho el Sabio 2010PergaminoDatos de impresión constan en el colofónSign.: [1-3]8, a-z8, A10, []2Error de encuadernación, hay 2 h. sin signatura entre A5 y A6 (h. CLXXXIX Y CXC)Al final 2 p. manuscrita

De arte curatiua libri quatuor

Lugar de publicación e impresor tomados de colofón.Signaturas: [signo desconocido]10, A-Z8, 2A-2C8, 2D4.Múltiples errores de paginación.Error de numeración: 101 en lugar de 201.Portada grabada xilográfica arquitectónica, con la leyenda: "vbi est thesavrvs tvvs ibi et cor tvvm".Capital grabada en p. 228 representando la danza de la muerte.Encuadernación renacentista del siglo XX en piel gofrada con hierros dorados en el lomoEx-libris manuscrito en portada: "... Ladron"