Analysis of the General Skills of Graduates in Environmental Sciences: The View of Students, Teachers and Employers

General competencies are crucial for the personal and professional growth of university graduates. This paper provides a critical analysis of the significance and level of competence development within the environmental sciences degree (ESD) context. The research involved surveys conducted among final-year students, faculty members, and industry employers. The survey results reveal that employers perceive the level of competence achieved to be higher than what teachers and students reported. However, all three groups acknowledge a high level of competence development for most skills. Nonetheless, certain competences such as critical thinking (CT), problem-solving, organisation, and planning need to be strengthened to better align with their perceived importance. Students tend to undervalue essential competences such as digital literacy and environmental awareness, contrary to international organisations’ recommendations. The study findings also underscore the necessity of enhancing “entrepreneurial skills” and emphasising the significance of the digital realm for students pursuing an environmental sciences degree

Holistic or Traditional Conceptions of Heritage among Early-Childhood and Primary Trainee Teachers

This study examines the conception of heritage—holistic or traditional—among future early-childhood and primary teachers. In order to do this, our objective was to analyze trainee teachers’ perceptions surrounding the conception of heritage. To carry out the analysis, we designed and validated a questionnaire with closed-ended questions (Likert scale 1–5) and one open-ended question about the elements that respondents considered to be part of what we define as heritage. The participants (n = 602) study at the universities of Alicante, Murcia, and Córdoba, and the investigation took place during 2018/19 and 2019/20 academic years. The results show a traditional conception that is still attached to immovable monumental heritage, with lower scores for intangible and natural heritage. However, there were some high scores for traditions and popular festivals, which are a frequent educational resource in early-childhood and primary classrooms. In conclusion, this non-holistic conception of heritage could be changed if an active and varied use of heritage resources were introduced from the early stages of education.This research was funded by the UNIVERSITY OF ALICANTE, grant number GRE18-13A; by the MINISTRY OF SCIENCE, INNOVATION AND UNIVERSITITES grant number PGC2018-094491-B-C33, and by GENERAL DIRECTORATE OF SCIENTIFIC AND TECHNICAL RESEARCH grant number HAR2015-68059-C2-1-R. This work was supported by the I3CE Network Programme of Research in University Teaching of the Vice-Rectorate of Educational Quality and Innovation–Institute of Educational Sciences of the UNIVERSITY OF ALICANTE (convened 2019–20), Grant number 4825

A Description of Ad-nilpotent Elements in Semiprime Rings with Involution

In this paper, we study ad-nilpotent elements in Lie algebras arising from semiprime associative rings R free of 2-torsion. With the idea of keeping under control the torsion of R, we introduce a more restrictive notion of ad-nilpotent element, pure ad-nilpotent element, which is a only technical condition since every ad-nilpotent element can be expressed as an orthogonal sum of pure ad-nilpotent elements of decreasing indices. This allows us to be more precise when setting the torsion inside the ring R in order to describe its ad-nilpotent elements. If R is a semiprime ring and a is an element of R is a pure ad-nilpotent element of R of index n with R free of t and ((n)(t))-torsion for t = [n+1/2], then n is odd and there exists lambda is an element of C(R) such that a - lambda is nilpotent of index t. If R is a semiprime ring with involution * and a is a pure ad-nilpotent element of Skew(R,*) free of t and ((n)(t))-torsion for t=[n+1/2], then either a is an ad-nilpotent element of R of the same index n (this may occur if n degrees 1,3(mod4)) or R is a nilpotent element of R of index t+1, and R satisfies a nontrivial GPI (this may occur if n degrees 0,3(mod4)). The case n degrees 2(mod4) is not possibl

Ad-Nilpotent Elements of Skew Index in Semiprime Rings with Involution

In this paper, we study ad-nilpotent elements of semiprime rings R with involution * whose indices of ad-nilpotence differ on Skew(R,*) and R. The existence of such an ad-nilpotent element a implies the existence of a GPI of R, and determines a big part of its structure. When moving to the symmetric Martindale ring of quotients Q(m)(s) (R) of R, a remains ad-nilpotent of the original indices in Skew(Q(m)(s) (R), *) and W-m(s) (R). There exists an idempotent e is an element of Q(m)(s) (R) that orthogonally decomposes a = ea + (1 - e)a and either ea and (1 - e)a are ad-nilpotent of the same index (in this case the index of adnilpotence of a in Skew(Q(m)(s) (R),*) is congruent with 0 modulo 4), or ea and (1 - e)a have different indices of ad-nilpotence (in this case the index of ad-nilpotence of a in Skew(Q(m)(s) (R), *) is congruent with 3 modulo 4). Furthermore, we show that Q(m)(s)(R) has a finite Z-grading induced by a *-complete family of orthogonal idempotents and that e Q(m)(s)(R)e, which contains ea, is isomorphic to a ring of matrices over its extended centroid. All this information is used to produce examples of these types of ad-nilpotent elements for any possible index of ad-nilpotence n

Heritage conception between Early-Childhood Education training teachers

Los autores de la investigación quieren agradecer la participación a los docentes en formación, así como a las tres instituciones de pertenencia: Universidad de Murcia, Universidad de Córdoba y Universidad de Alicante. Así mismo, agradecer a los respectivos grupos de investigación involucrados, así como a las experiencias previas llevadas a cabo en el grupo de investigación DICSO (Universidad de Murcia) y que han permitido el diseño del instrumento utilizado.La investigación educativa pocas veces presta atención a la enseñanza de contenidos conceptuales históricos en Educación Infantil, problema heredado de la visión psicoevolutiva piagetiana que impediría al alumnado de Infantil adquirir conocimientos abstractos. En esta investigación se plantea como objetivo conocer cuál es la concepción del profesorado en formación de Educación Infantil sobre los elementos culturales del patrimonio, puesto que son un contenido fundamental en la enseñanza de la historia escolar al servir de fuente primaria para conocer el pasado. La metodología empleada ha sido cualitativa-cuantitativa a través de un cuestionario que ha servido como instrumento de investigación y sus resultados analizados mediante SPSS 24. Los resultados muestran que el futuro profesorado de Educación Infantil tiene una visión limitada y no holística del concepto de patrimonio, donde se mantiene el peso de los grandes hitos y monumentos, a excepción de las fiestas y tradiciones populares que son un recurso muy presente en la Educación Infantil.Few times educative research pay attention to conceptual contents teaching in history education, inherited problem from the piagetinian psychoevolutive approach that indicates that children in Early-Childhood education are not able to learn abstract contents. In this paper, the target is to know the conception that Early-Childhood training teachers have about the concept of heritage, due to its importance as primary font to meet the past. The methodology implemented is qualitative quantitative using a questionnaire as evaluation instrument and SPSS 24 to analyze the results. These results show that future Early-Childhood teachers have a limited and no holistic conception of heritage, just taking in account big monuments except from popular traditions and folk that are a very used resource in Early-Childhood Education.Este trabajo es resultado del proyecto de investigación “El pensamiento geográfico e histórico del alumnado de Educación Primaria en la Región de Murcia: propuesta metodológica innovadora para una educación de calidad” (20874/PI/18). Proyecto financiado por la Comunidad Autónoma de la Región de Murcia a través de la convocatoria de Ayudas a proyectos para el desarrollo de investigación científica y técnica por grupos competitivos, incluida en el Programa Regional de Fomento de la Investigación Científica y Técnica (Plan de Actuación 2018) de la Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia

Recomendación para la determinación de HER2 en cáncer de mama : Consenso nacional de la sociedad española de anatomía patológica (SEAP) y de la sociedad española de oncología médica (SEOM)

La identificación de los carcinomas de mama con amplificación/sobreexpresión de HER2 es crítica en la práctica clínica diaria ya que estas neoplasias requieren un tratamiento específico que incluye el uso de terapias dirigidas. Tanto las técnicas de hibridación in situ como las técnicas inmunohistoquímicas son métodos apropiados para la identificación de cánceres de mama HER2 positivos. Sin embargo, numerosos estudios, incluidos los desarrollados por la Asociación para la Garantía de Calidad en Patología de la SEAP (AGCP) y la experiencia de centros de referencia nacionales en la determinación de HER2 han puesto de manifiesto importantes problemas de reproducibilidad entre laboratorios. Por estos motivos, patólogos expertos en la determinación de HER2 de estos centros de referencia, así como oncólogos médicos con una contrastada actividad en cáncer de mama, en representación de las sociedades respectivas (SEAP y SEOM), han trabajado para debatir y consensuar las recomendaciones nacionales de determinación de HER2. Estas recomendaciones se basan no sólo en la experiencia de los participantes en el consenso, sino también en la experiencia internacional publicada en recientes guías de distintos países, tales como Estados Unidos, Reino Unido y Canadá. En este consenso, se recomiendan los requisitos mínimos que un laboratorio de Anatomía Patológica debe cumplir para garantizar la adecuada determinación de HER2 en la práctica diaria. Aquellos laboratorios que carezcan de los estándares mínimos expuestos en esta guía deberían trabajar en alcanzarlos y durante este proceso remitir a laboratorios de referencia las muestras en las que la determinación de HER2 tenga implicaciones clínicas para las pacientes.Breast cancers with HER2 alterations are critical to identify because such tumors require unique treatment, including the use of targeted therapies. HER2 alterations at the DNA (amplification) and protein (overexpression) level usually occur in concert, and both in situ hybridization and immunohistochemistry can be accurate methods to assess these alterations. However, recent studies including those conducted by the Association for Quality Assessment of the Spanish Society of Pathology and the experience of several national reference centres for HER2 testing have suggested that serious reproducibility issues exist with both techniques. To address this, a joint committee of both the Spanish Society of Pathology and the Spanish Society of Medical Oncology has met to review guidelines for HER2 testing. Consensus recommendation are based not only on panellist’s experience but also in those consensus guidelines previously reported in several countries, such as United Stated, United Kingdom and Canada. These guidelines include minimal requirements that Pathology Department must meet in order to guarantee appropriate HER2 testing in breast cancer. Pathology laboratories that do not meet these standards must put effort to reach them and, in the meantime, send clinical cases to reference centres.Vera Sempere, Fco Jose, [email protected] ; Lluch Hernandez, Ana, [email protected]

Gobernanza y transparencia de las empresas públicas

This study is particularly important as public entities currently leave much to be desired in the area of transparency; therefore, the objective that was proposed was the following: "to analyze governance as an instrument for administrative transparency in the management of public companies in Manabí", for which a mixed methodology was applied, both bibliographic and field, thus obtaining results complemented as primary and secondary information, information collection techniques were applied as is the case of surveys; A sample of 250 employees and 384 users was considered. Considering the above, fundamental results were obtained, among which it is specified that currently the level of application of governance and transparency in the management of public companies in Manabí is very low and fails to meet the needs of citizens regarding the required participation, which keeps the institution away from citizens with a low impact and positioning; In addition, in its administrative and managerial processes, it is not linked to social actors. As a result of this process, it can be established as a main conclusion that improvements are required at the institutional level, the implementation of transparency and communication protocols to citizens, allowing the continuous and joint action of social actors in an integrated manner in the administrative and operational processes of public companies in Manabí, thus leading the entity to a governance framework required by the needs of today's society.   El presente estudio conlleva especial importancia ya que actualmente las entidades públicas dejan mucho que desear en el ámbito de la transparencia; por lo cual el objetivo que se planteo fue el siguiente: “analizar la gobernanza como instrumento para la transparencia administrativa en la gestión de las empresas públicas de Manabí”, para lo que se aplicó una metodología mixta tanto bibliográfica como de campo, obteniendo así resultados complementados como información primaria y secundaria, se aplicaron técnicas de recolección de información como es el caso de las encuestas; se consideró una muestra de 250 empleados y 384 usuarios. Considerando lo antes mencionado, se obtuvieron resultados fundamentales entre los cuales se especifica que actualmente el nivel de aplicación de la gobernanza y la trasparencia en la gestión de las empresas públicas de Manabí es muy bajo y no llega a solventar las necesidades de la ciudadanía respecto de la participación requerida, lo cual mantiene a la institución alejada de la ciudadanía con un bajo impacto y posicionamiento; además, en sus procesos administrativos y directivos no se vincula a los actores sociales. Producto de este proceso, se puede establecer como conclusión principal que se requiere mejoras a nivel institucional, la implementación de protocolos de transparencia y comunicación a la ciudadanía, permitiendo la acción continua y conjunta de los actores sociales de manera integrada en los procesos tanto administrativos como operativos de las empresas públicas de Manabí, llevando así a la entidad a un marco de gobernanza requerido por las necesidades de la sociedad actual. &nbsp

A strategic reflection for the management and implementation of CAR-T therapy in Spain: an expert consensus paper

CAR-T cell therapy represents a therapeutic revolution in the prognosis and treatment of patients with certain types of hematological cancer. However, they also pose new challenges in the healthcare, regulatory and financial fields. The aim of the RET-A project was to undertake a strategic reflection on the management of CAR-T therapies within the Spanish National Health System, to agree on recommendations that will help to better deal with the new context introduced by these cell therapies in the present and in the future. This think tank involved 40 key agents and opinion leaders. The experts identified three great challenges for implementing advanced therapies in Spain: therapeutic individualisation, with a multidisciplinary approach; acceleration of access times, by minimizing bureaucracy; and increase in the number of centers qualified to manage the CAR-T therapies in the NHS. The experts agreed on the ideal criteria for designating those qualified centers. They also agreed on a comprehensive CAR-T care pathway with the timings and roles which would ideally be involved in each part of the process.This study was funded by Gilead Sciences, Inc.Peer reviewe

Latin American Collaborative Research on Aplastic Anemia (LARAA): creating a regional registry

Aplastic anemia (AA) is a rare but serious disease that affects hematopoietic stem cells and is characterized by pancytopenia and a hypocellular bone marrow. It can be a hereditary or acquired condition. Acquired AA has an incidence of 2 per million per year in Europe, but the incidence is two to three times higher in Asia. In Latin America, there is little epidemiologic data on this disease. The most important treatments for AA are bone marrow transplantation and immunosuppressive treatment with antithymocyte globulin and cyclosporine. But access to these treatments is restricted in some areas of Latin America. At the American Society of Hematology (ASH) Annual Meeting in 2016, representatives of the Hematology Societies of Latin America, with the support of the ASH International Program, met to discuss possible collaborative efforts. Everyone agreed that lack of reliable information is one of the main barriers to designing significant clinical trials for the region; therefore, starting a registry of hematologic diseases for the region has become a main goal of the group. In April 2017, at the ASH Highlights meeting in Latin America, AA was selected as the first disease that would be used to begin the collaborative action. National hematology societies of Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Paraguay, Peru, Uruguay, and Venezuela have made a commitment to help develop the Latin American Registry for Aplastic Anemia (LARAA)

Direct oral anticoagulants in patients with hypertrophic cardiomyopathy and atrial fibrillation.

Background: Chronic anticoagulation with vitamin K antagonists (VKAs) is recommended in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Direct oral anticoagulants (NOACs) are an alternative to VKAs but there are limited data to support their use in HCM. We sought to describe the pattern of use, thromboembolic events, bleeding and quality of life in patients with HCM and AF treated with NOACs. Methods: Data from patients treated with NOACs (n=99) and VKA (n=433) at 9 inherited cardiac diseases units were retrospectively collected. Annual rates of embolic events, serious bleeding and death were analysed and compared. Quality of life and treatment satisfaction were evaluated with SF-36 and SAFUCA questionnaires in 80 NOAC-treated and 57 VKA-treated patients. Results: After median follow-up of 63 months (IQR:26–109), thromboembolic events (TIA/stroke and peripheral embolism) occurred in 10% of patients on oral anticoagulation. Major/clinically relevant bleeding occurred in 3.8% and the global mortality rate was 23.3%. Thromboembolic event rate was 0.62 per 100 patient-years in the NOAC group vs. 1.59 in the VKA group [subhazard ratio (SHR) 0.32;95%CI:0.04– 2.45;p=0.27]. Major/clinically relevant bleeding occurred in 0.62 per 100 person-years in the NOAC group vs. 0.60 in the VKA group (SHR 1.28;95%CI 0.18–9.30;p=0.85). Quality of life scores were similar in both groups; however, NOAC-treated patients achieved higher scores in the SAFUCA. Conclusions: HCM patients with AF on NOACs showed similar embolic and bleeding rates to those on VKA. Although quality of life was similar in both groups, the NOAC group reported higher treatment satisfaction.pre-print929 K