Concurrent Validity and Reliability of Two Portable Powermeters (Power2Max vs. PowerTap) to Measure Different Types of Efforts in Cycling

[EN] The purpose was to assess the concurrent validity and reliability of two portable powermeters (PowerTap vs. Power2Max) in different types of cycling efforts. Ten cyclists performed two submaximal, one incremental maximal and two supramaximal sprint tests on an ergometer, while pedaling power and cadence were registered by both powermeters and a cadence sensor (GarminGSC10). During the submaximal and incremental maximal tests, significant correlations were found for power and cadence data (r = 0.992–0.997 and 0.996–0.998, respectively, p < 0.001), with a slight power underestimation by PowerTap (0.7–1.8%, p < 0.01) and a high reliability of both powermeters (p < 0.001) for measurement of power (ICC = 0.926 and 0.936, respectively) and cadence (ICC = 0.969 and 0.970, respectively). However, during the supramaximal sprint test, their agreement to measure power and cadence was weak (r = 0.850 and 0.253, p < 0.05) due to the low reliability of the cadence measurements (ICC between 0.496 and 0.736, and 0.574 and 0.664, respectively; p < 0.05) in contrast to the high reliability of the cadence sensor (ICC = 0.987–0.994). In conclusion, both powermeters are valid and reliable for measuring power and cadence during continuous cycling efforts (~100–450 W), but questionable during sprint efforts (>500 W), where they are affected by the gear ratio used (PowerTap) and by their low accuracy in cadence recording (PowerTap and Power2Max).S

Biphasic Bioceramic Obtained from Byproducts of Sugar Beet Processing for Use in Bioactive Coatings and Bone Fillings

This study focuses on developing hydroxyapatite synthesized from a CaCO3 -rich byproduct of sugar beet processing called Carbocal® using a hydrothermal reactor. The purpose of this biomaterial is to enhance the osteoinductivity of implantable surfaces and serve as a bone filler, providing a sustainable and economically more affordable alternative. This research involved compositional analysis and micro- and macrostructural physicochemical characterization, complemented with bioactivity and live/dead assays. The biphasic nature of the Carbocal®-derived sample was significant within the context of the bioactivity concept previously proposed in the literature. The bioactivity of the biomaterial was demonstrated through a viability test, where the cell growth was nearly equivalent to that of the positive control. For comparison purposes, the same tests were conducted with two additional samples: hydroxyapatite obtained from CaCO3 and commercial hydroxyapatite. The resulting product of this process is biocompatible and possesses properties similar to natural hydroxyapatite. Consequently, this biomaterial shows potential as a scaffold in tissue engineering and as an adhesive filler to promote bone regeneration within the context of the circular bioeconomy in the geographical area proposed.Junta de Andalucía14 página

Thickening of the pituitary stalk in children and adolescents with central diabetes insipidus: Causes and consequences

Background: Central diabetes insipidus (CDI) is a rare disorder in children. The aetiology of CDI in childhood is heterogeneous. The aim of this study is to illustrate the importance of a careful clinical and neuro-radiological follow-up of the pituitary and hypothalamus region in order to identify the aetiology and the development of associated hormonal deficiencies. Methods: Clinical and auxological variables of 15 children diagnosed with CDI were retrospectively analysed in a paediatric hospital. Evaluations of adenohypophyseal function and cranial MRI were performed periodically. Results: The mean age at diagnosis of CDI was 9.6 years (range: 1.32-15.9). The aetiological diagnosis could be established initially in 9 of the 15 patients, as 7 with a germinoma and 2 with a histiocytosis. After a mean follow-up of 5.5 years (range: 1.6-11.8), the number of idiopathic cases was reduced by half. At the end of the follow-up, the aetiological diagnoses were: 9 germinoma (60%), 3 histiocytosis (20%), and 3 idiopathic CDI (20%). There is a statistically significant association between stalk thickening and tumour aetiology. At least one adenohypophyseal hormonal deficiency was found in 67% of cases, with the majority developing in the first two years of follow-up. Growth hormone deficiency (60%) was the most prevalent. Conclusion: The follow-up of CDI should include hormone evaluation with special attention, due to its frequency, to GH deficiency. In addition, a biannual MRI in an idiopathic CDI should be performed, at least during the first 2-3 years after diagnosis, as 50% of them were diagnosed with a germinoma or histiocytosis during this period.Introducción: La diabetes insípida central (DIC) es una entidad poco frecuente en la edad pediátrica, siendo su etiología heterogénea. El objetivo de nuestro trabajo es demostrar que el seguimiento clínico y neurorradiológico de la región hipotálamo-hipofisaria, puede ayudar a establecer el diagnóstico etiológico de DIC y la presencia de otros déficits hormonales. Métodos: Se revisaron de forma retrospectiva 15 pacientes diagnosticados de DIC en un hospital pediátrico. Se analizaron las características clínicas y auxológicas; así como la valoración de la función adenohipofisaria junto con RM craneal de manera periódica. Resultados: La mediana de edad al diagnóstico fue de 9,6 a˜nos (rango: 1,3-15,9). El diagnóstico etiológico pudo establecerse en 9 de los 15 pacientes (germinomas: 7 e histiocitosis: 2). Tras una mediana de seguimiento de 5,5 a˜nos (rango: 1,6-11,8), los casos idiopáticos se redujeron a la mitad. Finalmente, los diagnósticos etiológicos fueron: germinoma 9 (60%), histiocitosis 3 (20%) y DIC idiopática 3 (20%). Existe una asociación estadísticamente significativa entre el engrosamiento del tallo y la etiología tumoral. El 67% desarrolló, al menos, una deficiencia hormonal adenohipofisaria, la mayoría en los dos primeros a˜nos de seguimiento. El déficit más prevalente fue el de hormona de crecimiento (60%). Conclusiones: En todos los pacientes con DIC se deberá realizar un control auxológico y hormonal, con especial atención, por su frecuencia, a la deficiencia de GH, y en aquellos con DIC idiopática se debería incluir una RM semestral, al menos durante los 2-3 primeros a˜nos después del diagnóstico, pues en nuestro estudio el 50% fueron diagnosticados de germinomas o histiocitosis en este period

Plan estratégico del organismo de evaluación y fiscalización ambiental para la industria cervecera del Perú con enfoque en economía circular

El sector cervecero en el Perú, se caracteriza por tener pocos participantes, un diversificado portafolio de marcas, altas barreras de entrada entre otros, pero además no está exenta de generar residuos y desperdicios que generan algún grado de contaminación. Por otro lado, el Organismo de Evaluación y Fiscalización Ambiental (OEFA), es la entidad pública especializada que busca la protección del medio ambiente en las diferentes actividades económicas. En razón a que el presente plan estratégico está enfocado en la Industria Cervecera Peruana, la visión que se plantea, es que El OEFA velará para que las actividades económicas de la Industria Cervecera en el 2025, sean un referente en el Perú en el uso de la economía circular, asegurando el derecho de las personas a gozar de un ambiente sano. Este plan estratégico plantea objetivos a largo plazo que están orientadas al cuidado del medio ambiente pero además, a reducir los desperdicios generados, logrando la creación de nuevos productos derivados, como ya se hace en otros países, mediante la utilización de los residuos de la producción de la cerveza, que en algunos casos pueden ser incorporados en el proceso productivo. Esto representa una gran oportunidad de generar nuevos negocios y para ello se requiere un marco regulatorio del OEFA. A partir de estos objetivos se plantean estrategias específicas, las cuales con la debida implementación y seguimiento, por parte de todos los actores que forman parte del sector así como del OEFA en su labor promotora y reguladora, permitirán armonizar el ejercicio de las actividades económicas y la protección del ambiente.Beer industry in Peru is known for having a reduce amount of participants, a diverse assortment of brands and high requirements in order to participate in. However, the industry is not blameless with regard to industrial waste and pollution. Agency for Environmental Assessment and Enforcement (OEFA) is the public entity that specializes in the evaluation, supervision, and regulations that oversee environmental protection within the various economic enterprises. A proposal by the OEFA outlines the close supervision of the business practices of the Beer Industry in 2025. One of the strategies OEFA asserts in this proposal is the use of the circular economy thereby further guaranteeing the right of the people to enjoy a healthy environment. This strategic plan proposes long-term environmental protection objectives and an optimization of waste management, creating new products by recycling the waste from beer production. With this new window of opportunities for business, a regulatory outline is required from the OEFA. If the specific strategies proposed are properly implemented and each participant follows ethical business practices, then a true balance between the economy and environment will be found.Tesi

Exposición sucinta y sencilla de la provincia de Nuevo México y otros escritos

Producción CientíficaHistoria de Nuevo México a través de la obra de Pedro Baptista Pino y Juan López Cancelada.Departamento de Historia Moderna, Contemporánea y de América, Periodismo y Comunicación Audiovisual y PublicidadProyecto de Investigación (HUM2006-09045-C03- 01/FILO)Junta de Castilla y León (LE029A07

Adipokines induce pro-inflammatory factors in activated Cd4+ T cells from osteoarthritis patient

Osteoarthritis (OA) is a chronic systemic musculoskeletal disorder involving inflammation, immunity and metabolic alterations. OA is commonly regarded as non-inflammatory disease; still inflammation is recognized as contributing to the symptoms and progression of OA. New evidence suggests that adipokines are involved in the pathophysiology of OA and might modulate the production of inflammatory mediators including in immune cells. However, the role of immune component in osteoarthritis is still poorly investigated. To gain further insights into the interaction of immune cells in OA and the role of adipokines on these cells, we performed experiments aimed to determine the cytokine profile in activated CD4+ T cells from OA patients. For completeness, we also explored the cross talk between T lymphocytes and chondrocytes in OA by co-culturing human primary chondrocytes with activated CD4+ T cells in two ways: the first by incubating the cells by direct contact (D.C.) or by transwell system. Our results show that the exposure of activated CD4+ T cells to adipokines modulates IL-6, IL-8 and CCL-3 production. In addition, the production of key macromolecules of ECM (aggrecan and collagen-2) and matrix metalloproteinase 13 (MMP-13) in co-cultured chondrocytes with activated CD4+ T cells was altere

Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

Here, we assessed whether 41 SNPs within steroid hormone genes associated with erosive disease. The most relevant finding was the rheumatoid factor (RF)-specific effect of the CYP1B1, CYP2C9, ESR2, FcγR3A, and SHBG SNPs to modulate the risk of bone erosions (P = 0.004, 0.0007, 0.0002, 0.013 and 0.015) that was confirmed through meta-analysis of our data with those from the DREAM registry (P = 0.000081, 0.0022, 0.00074, 0.0067 and 0.0087, respectively). Mechanistically, we also found a gender-specific correlation of the CYP2C9rs1799853T/T genotype with serum vitamin D3 levels (P = 0.00085) and a modest effect on IL1β levels after stimulation of PBMCs or blood with LPS and PHA (P = 0.0057 and P = 0.0058). An overall haplotype analysis also showed an association of 3 ESR1 haplotypes with a reduced risk of erosive arthritis (P = 0.009, P = 0.002, and P = 0.002). Furthermore, we observed that the ESR2, ESR1 and FcγR3A SNPs influenced the immune response after stimulation of PBMCs or macrophages with LPS or Pam3Cys (P = 0.002, 0.0008, 0.0011 and 1.97•10−7). Finally, we found that a model built with steroid hormone-related SNPs significantly improved the prediction of erosive disease in seropositive patients (PRF+ = 2.46•10−8) whereas no prediction was detected in seronegative patients (PRF− = 0.36). Although the predictive ability of the model was substantially lower in the replication population (PRF+ = 0.014), we could confirm that CYP1B1 and CYP2C9 SNPs help to predict erosive disease in seropositive patients. These results are the first to suggest a RF-specific association of steroid hormone-related polymorphisms with erosive disease