Zinc Selective Ionophores for Potentiometric and Optical Sensors

Iminodiacetamide derivatives were synthesized and studied as ionophores in plasticized poly(vinyl chloride) membranes with potentiometric and optical transduction. The N-benzyl and N-phenyl derivatives proved to have a distinct zinc selectivity preferring Zn2+ over Ca2+, Na+ by factors of 6x105 and 3x104, respectively. All ionophores exhibit a serious proton interference (logKPottzn + +,H1+ - 6) which suggests that all application of this type of ionophores based sensors are limited to hydrogen ion buffer solution at pH ≥ 6. © 1992, Taylor & Francis Group, LLC. All rights reserved

Analytical performances of lipophilic diamides based alkaline earth ion‐selective electrodes

Based on complex chemical considerations, lipophilic diamide derivatives have been designed and synthesized as ionophores for liquid membrane electrodes. The structure‐selectivity studies revealed that the majority of the ligands exhibit calcium ion selectivity, except the compound bis‐N,N‐dicyclohexyl‐malonamide. The latter has an almost equal selectivity for Ca2+ and Mg2+ and sufficiently rejects sodium ions, thus it lends itself to water hardness measurements. Copyright © 1993 VCH Publishers, Inc

Novel bis (crown ether)-based potassium sensor for biological applications

Based on structure-selectivity studies on bis-benzo-crown ether derivatives, 2,2′-bis[3,4-(15-crown-5)-2-nitrophenylcarbamoxymethyl]tetradecane (BME-44) was designed and synthesized. The performance characteristics of this new, highly lipophilic ionophore of the group of bis-nitrobenzo-15-crown-5 derivatives with urethane linkage when used in liquid membrane electrodes are evaluated with special regard to the requirements of biological and clinical applications. Potentiometric steady-state and flow-through dynamic data are presented to prove the sensor capabilities for clinical and physiological potassium determinations. © 1990 Springer-Verlag

Benzocrown derivatives as ionophores for alkali cations, I synthesis of urethane‐ and urea‐linked mono‐ and bis‐crown ethers

New mono‐ and bis‐benzocrown ethers (5–28 and 29–48) with different substituents and connecting chains were prepared with the aim to develop novel alkali cation‐transport mediators for biological systems. The alkali cation selectivities of the title compounds were determined in ion‐selective membrane electrodes. Remarkable potassium selectivity was observed with several bis‐(benzo‐15‐crown‐5)urethanes. Copyright © 1988 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinhei